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Amsterdam; New York: Excerpta Medica, Elsevier Science Pub. 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Medical Sciences Division. (2008) Analysis of non-steady state physiological and pathological processes [Thesis (D Phil)]: University of Oxford, 2008. 2 v. p."},{"key":"ref54","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington disease: natural history, biomarkers and prospects for therapeutics","volume":"10","author":"CA Ross","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"ref55","first-page":"553","article-title":"Interrelations between sleep and the somatotropic axis","volume":"21","author":"E Van Cauter","year":"1998","journal-title":"Sleep"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.expneurol.2009.05.012","article-title":"Huntington's disease: the current state of research with peripheral tissues","volume":"219","author":"J Sassone","year":"2009","journal-title":"Exp 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oxytocin and vasopressin in the hypothalamus in early Huntington disease: a case study","author":"S Gabery","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1750-3639.2012.00565.x","article-title":"Paraventricular nucleus neuropeptide expression in Huntington's disease patients","volume":"22","author":"DJ van Wamelen","year":"2012","journal-title":"Brain Pathol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1471-4159.2005.03035.x","article-title":"Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates","volume":"93","author":"S Kotliarova","year":"2005","journal-title":"J Neurochem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/00001756-199209000-00022","article-title":"Circadian rhythms of vasopressin content in the suprachiasmatic nucleus of the rat","volume":"3","author":"K Tominaga","year":"1992","journal-title":"Neuroreport"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1210\/jcem-68-3-688","article-title":"Arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia in type 1 (insulin-dependent) diabetes","volume":"68","author":"BM Fisher","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/jnnp.41.2.135","article-title":"Growth hormone and prolactin response to bromocriptine in patients with Huntington's chorea","volume":"41","author":"RJ Chalmers","year":"1978","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0024-3205(79)90357-6","article-title":"Growth hormone and prolactin secretion in Huntington's disease","volume":"24","author":"CL Levy","year":"1979","journal-title":"Life Sci"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000115147","article-title":"Spontaneous nocturnal plasma prolactin and growth hormone secretion in patients with Parkinson's disease and Huntington's chorea","volume":"19","author":"L Murri","year":"1980","journal-title":"Eur Neurol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1530\/eje.0.1510451","article-title":"Circulating and cerebrospinal fluid ghrelin and leptin: potential role in altered body weight in Huntington's disease","volume":"151","author":"V Popovic","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/jnnp.46.12.1134","article-title":"Twenty-four hour plasma levels of growth hormone and prolactin in Huntington's disease","volume":"46","author":"R Durso","year":"1983","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1210\/jcem-44-5-870","article-title":"Altered growth hormone and prolactin responses to dopaminergic stimulation in Huntington's chorea","volume":"44","author":"T Caraceni","year":"1977","journal-title":"J Clin Endocrinol Metab"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1210\/jcem-64-1-51","article-title":"Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations","volume":"64","author":"KY Ho","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"ref94","first-page":"R1351","article-title":"Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion","volume":"276","author":"N Shah","year":"1999","journal-title":"Am J Physiol"},{"key":"ref95","first-page":"1441","article-title":"A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day","volume":"74","author":"E Van Cauter","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1210\/jcem-72-4-854","article-title":"Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages","volume":"72","author":"RW Holl","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"ref97","first-page":"1451","article-title":"Sleep, awakenings, and insulin-like growth factor-I modulate the growth hormone (GH) secretory response to GH-releasing hormone","volume":"74","author":"E Van Cauter","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"ref98","first-page":"4396","article-title":"Nocturnal growth hormone (GH) secretion is eliminated by infusion of GH-releasing hormone antagonist","volume":"81","author":"B Ocampo-Lim","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref99","article-title":"Plasma melatonin is reduced in Huntington's disease","author":"E Kalliolia","year":"2014","journal-title":"Mov Disord"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2265.1993.tb01773.x","article-title":"Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone","volume":"39","author":"R Valcavi","year":"1993","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1530\/eje.0.1410022","article-title":"Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects","volume":"141","author":"DR Meeking","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1677\/joe.0.1540057","article-title":"Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects","volume":"154","author":"J Sulcova","year":"1997","journal-title":"J Endocrinol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0140-6736(77)90272-0","article-title":"Prolactin control in Huntington's chorea","volume":"2","author":"EE Muller","year":"1977","journal-title":"Lancet"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0024-3205(78)90616-1","article-title":"Neuroendocrine function in Huntington's disease: dopaminergic regulation of prolactin release","volume":"22","author":"E Caine","year":"1978","journal-title":"Life Sci"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(77)90608-0","article-title":"Impaired prolactin release in Huntington's chorea. Evidence for dopaminergic excess","volume":"2","author":"MR Hayden","year":"1977","journal-title":"Lancet"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0022-510X(89)90120-2","article-title":"Endocrine functions in Huntington's disease. A two-and-a-half years follow-up study","volume":"90","author":"HP Kremer","year":"1989","journal-title":"J Neurol Sci"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/sleep\/17.1.20","article-title":"Prolactin secretion and sleep","volume":"17","author":"K Spiegel","year":"1994","journal-title":"Sleep"},{"key":"ref108","first-page":"1483","article-title":"Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels- a clinical research center study","volume":"81","author":"J Waldstreicher","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1210\/jcem-55-5-849","article-title":"Effects of "jet lag" on hormonal patterns. III. Demonstration of an intrinsic circadian rhythmicity in plasma prolactin","volume":"55","author":"D Desir","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"ref110","first-page":"543","article-title":"Temporal relationship between prolactin secretion and slow-wave electroencephalic activity during sleep","volume":"18","author":"K Spiegel","year":"1995","journal-title":"Sleep"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ajpa.1330670304","article-title":"An anthropometric assessment of Huntington's disease patients and families","volume":"67","author":"LA Farrer","year":"1985","journal-title":"Am J Phys Anthropol"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ajmg.1320210213","article-title":"Anthropometric discrimination among affected, at-risk, and not-at-risk individuals in families with Huntington disease","volume":"21","author":"LA Farrer","year":"1985","journal-title":"Am J Med Genet"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nut.2003.10.007","article-title":"Assessment of the nutrition status of patients with Huntington's disease","volume":"20","author":"A Trejo","year":"2004","journal-title":"Nutrition"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the brain: widespread pathology in Huntington's disease","volume":"8","author":"JM van der Burg","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/mds.870110509","article-title":"Characteristics of individuals with Huntington disease in long-term care","volume":"11","author":"MA Nance","year":"1996","journal-title":"Mov Disord"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/jcem-70-2-403","article-title":"Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman","volume":"70","author":"G Brabant","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"ref117","first-page":"3270","article-title":"Progressive elevation of plasma thyrotropin during adaptation to simulated jet lag: effects of treatment with bright light or zolpidem","volume":"81","author":"U Hirschfeld","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2869.1992.tb00036.x","article-title":"Nocturnal plasma thyrotropin variations are related to slow-wave sleep","volume":"1","author":"B Goichot","year":"1992","journal-title":"J Sleep Res"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0304-3940(95)12082-F","article-title":"Temporal link between plasma thyrotropin levels and electroencephalographic activity in man","volume":"200","author":"C Gronfier","year":"1995","journal-title":"Neurosci Lett"},{"key":"ref120","first-page":"E536","article-title":"Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms","volume":"273","author":"OM Buxton","year":"1997","journal-title":"Am J Physiol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1210\/jc.2007-2674","article-title":"Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels","volume":"93","author":"W Russell","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1212\/WNL.0b013e3181e62076","article-title":"High insulinlike growth factor I is associated with cognitive decline in Huntington disease","volume":"75","author":"N Saleh","year":"2010","journal-title":"Neurology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0138848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T22:15:58Z","timestamp":1748643358000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0138848"}},"subtitle":[],"editor":[{"given":"Raul M.","family":"Luque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,2]]},"references-count":122,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0138848","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,2]]}}}