{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:46:37Z","timestamp":1790401597344,"version":"4.1.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0138870","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T14:19:47Z","timestamp":1443190787000},"page":"e0138870","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System"],"prefix":"10.1371","volume":"10","author":[{"given":"Ganesh Ram R.","family":"Visweswaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Gholizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel H. J.","family":"Ruiters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grietje","family":"Molema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert J.","family":"Kok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan. A. A. M.","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.addr.2010.08.012","article-title":"Targeting podocyte-associated diseases","volume":"62","author":"JW Leeuwis","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.2337\/db13-0795","article-title":"Endothelial-podocyte crosstalk: the missing link between endothelial dysfunction and albuminuria in diabetes","volume":"62","author":"FS Siddiqi","year":"2013","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MNH.0b013e32832c9dba","article-title":"Glomerular filtration barrier","volume":"18","author":"B Haraldsson","year":"2009","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e11837","DOI":"10.1371\/journal.pone.0011837","article-title":"Establishment of protein delivery systems targeting podocytes","volume":"5","author":"WC Chiang","year":"2010","journal-title":"PLoS ONE"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e9463","DOI":"10.1371\/journal.pone.0009463","article-title":"Novel siRNA delivery system to target podocytes in vivo","volume":"5","author":"PV Hauser","year":"2010","journal-title":"PLoS ONE"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm.3313","article-title":"AKT2 is essential to maintain podocyte viability and function during chronic kidney disease","volume":"19","author":"G Canaud","year":"2013","journal-title":"Nat Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1172\/JCI57935","article-title":"The targeted podocyte","volume":"121","author":"AB Fogo","year":"2011","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1021\/mp4001124","article-title":"Anti-VCAM-1 and anti-E-selectin SAINT-O-Somes for selective delivery of siRNA into inflammation-activated primary endothelial cells","volume":"10","author":"PS Kowalski","year":"2013","journal-title":"Mol Pharm"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jconrel.2010.03.003","article-title":"Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells","volume":"144","author":"JE Adrian","year":"2010","journal-title":"J Control Release"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","article-title":"A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression","volume":"13","author":"MA Saleem","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/excr.1997.3739","article-title":"Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines","volume":"236","author":"P Mundel","year":"1997","journal-title":"Exp Cell Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1182\/blood-2009-05-220434","article-title":"Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo","volume":"114","author":"E Jin","year":"2009","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0003-2670(61)80041-X","article-title":"A rapid and sensitive sub-micro phosphorus determination","volume":"24","author":"CJF B\u00f6ttcher","year":"1961","journal-title":"Analytica Chimica Acta"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/BF02531316","article-title":"Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots","volume":"5","author":"G Rouser","year":"1970","journal-title":"Lipids"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1242\/jcs.126888","article-title":"Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2\/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis","volume":"126","author":"N Khattree","year":"2013","journal-title":"J Cell Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"1","author":"V Vichai","year":"2006","journal-title":"Nat Protocols"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1708::AID-IMMU1708>3.0.CO;2-Y","article-title":"VCAM-1 is internalized by a clathrin-related pathway in human endothelial cells but its alpha 4 beta 1 integrin counter-receptor remains associated with the plasma membrane in human T lymphocytes","volume":"28","author":"I Ricard","year":"1998","journal-title":"Eur J Immunol"},{"key":"ref18","first-page":"7190","article-title":"Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs","volume":"62","author":"P Sapra","year":"2002","journal-title":"Cancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"F418","DOI":"10.1152\/ajprenal.90319.2008","article-title":"mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes","volume":"296","author":"B Vollenbr\u00f6ker","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2012.12.016","article-title":"Targeted adenovirus mediated inhibition of NF-\u03baB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo","volume":"166","author":"JM Ku\u0142do","year":"2013","journal-title":"J Control Release"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cyto.2008.12.001","article-title":"TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells","volume":"46","author":"H-X Gao","year":"2009","journal-title":"Cytokine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2013.12.029","article-title":"Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo","volume":"176","author":"PS Kowalski","year":"2014","journal-title":"J. Control. Rel"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"F1630","DOI":"10.1152\/ajprenal.00400.2011","article-title":"MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation","volume":"302","author":"SA Asgeirsd\u00f3ttir","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"F554","DOI":"10.1152\/ajprenal.00391.2007","article-title":"Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes. Am. J. Physiol.","volume":"294","author":"SA \u00c1sgeirsd\u00f3ttir","year":"2008","journal-title":"Renal Physiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0138870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T04:19:48Z","timestamp":1653193188000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0138870"}},"subtitle":[],"editor":[{"given":"Feng","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,25]]},"references-count":24,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0138870","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,25]]}}}