{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:50:22Z","timestamp":1792752622775,"version":"4.5.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0139073","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T13:50:46Z","timestamp":1443448246000},"page":"e0139073","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":107,"title":["Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma"],"prefix":"10.1371","volume":"10","author":[{"given":"G-Andre","family":"Banat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Tretyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soni Savai","family":"Pullamsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weigert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Olesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Ebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Stiewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Grimminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Seeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Savai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"R Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"ref2","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"CA: a cancer journal for clinicians"},{"issue":"5 Suppl","key":"ref3","doi-asserted-by":"crossref","first-page":"e30S","DOI":"10.1378\/chest.12-2346","article-title":"Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"SP Nana-Sinkam","year":"2013","journal-title":"Chest"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/BF00184595","article-title":"Oncogene overexpression in non-small-cell lung cancer tissue: prevalence and clinicopathological significance","volume":"72","author":"J Lorenz","year":"1994","journal-title":"Clin Investig"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ng.2396","article-title":"Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer","volume":"44","author":"M Peifer","year":"2012","journal-title":"Nat Genet"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"D Hanahan","year":"2011","journal-title":"Cell"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1158\/0008-5472.CAN-12-0122","article-title":"Tumor microenvironment complexity: emerging roles in cancer therapy","volume":"72","author":"MA Swartz","year":"2012","journal-title":"Cancer Res"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","volume":"21","author":"D Hanahan","year":"2012","journal-title":"Cancer cell"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1164\/rccm.201409-1671PP","article-title":"The non-small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome","volume":"191","author":"R Remark","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","article-title":"Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer","volume":"39","author":"G Bindea","year":"2013","journal-title":"Immunity"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nrc2444","article-title":"The role of myeloid cells in the promotion of tumour angiogenesis","volume":"8","author":"C Murdoch","year":"2008","journal-title":"Nature reviews Cancer"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1164\/rccm.201406-1137OC","article-title":"Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer","volume":"191","author":"A Schmall","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1517\/13543784.2012.693478","article-title":"Tumor-stromal interactions in lung cancer: novel candidate targets for therapeutic intervention","volume":"21","author":"N El-Nikhely","year":"2012","journal-title":"Expert Opin Investig Drugs"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S2213-2600(13)70159-0","article-title":"Lung cancer: potential targets for immunotherapy","volume":"1","author":"E Tartour","year":"2013","journal-title":"The Lancet Respiratory medicine"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1067\/mlc.2002.128317","article-title":"Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression","volume":"140","author":"A Kataki","year":"2002","journal-title":"J Lab Clin Med"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.athoracsur.2008.10.067","article-title":"Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms","volume":"87","author":"E Ruffini","year":"2009","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/cncr.23712","article-title":"Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer","volume":"113","author":"O Kawai","year":"2008","journal-title":"Cancer"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jss.2009.08.029","article-title":"Density of tumor-infiltrating lymphocytes correlates with disease recurrence and survival in patients with large non-small-cell lung cancer tumors","volume":"167","author":"A Kilic","year":"2011","journal-title":"J Surg Res"},{"issue":"16","key":"ref19","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1158\/1078-0432.CCR-08-0133","article-title":"Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer","volume":"14","author":"KI Al-Shibli","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1164\/rccm.201202-0335OC","article-title":"Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension","volume":"186","author":"R Savai","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/nm.3695","article-title":"Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension","volume":"20","author":"R Savai","year":"2014","journal-title":"Nat Med"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.4049\/jimmunol.1303048","article-title":"Adventitial fibroblasts induce a distinct proinflammatory\/profibrotic macrophage phenotype in pulmonary hypertension","volume":"193","author":"KC El Kasmi","year":"2014","journal-title":"J Immunol"},{"key":"ref23","volume":"xix","author":"P McCullagh","year":"1989"},{"issue":"2","key":"ref24","first-page":"3","article-title":"A peer-reviewed, open-access publication of the R Foundation for Statistical Computing","volume":"3","author":"H Turner","year":"2011","journal-title":"R Journal"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1037\/0033-2909.118.3.392","article-title":"Regression analyses of counts and rates: Poisson, overdispersed Poisson, and negative binomial models","volume":"118","author":"W Gardner","year":"1995","journal-title":"Psychological bulletin"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/JTO.0b013e3182037b76","article-title":"The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer","volume":"6","author":"RM Bremnes","year":"2011","journal-title":"J Thorac Oncol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"741741","DOI":"10.1155\/2012\/741741","article-title":"Tumor-induced CD8+ T-cell dysfunction in lung cancer patients","volume":"2012","author":"H Prado-Garcia","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"35","key":"ref28","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1200\/JCO.2005.01.4910","article-title":"Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer","volume":"23","author":"TJ Welsh","year":"2005","journal-title":"J Clin Oncol"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.4049\/jimmunol.1100558","article-title":"A critical role for macrophages in promotion of urethane-induced lung carcinogenesis","volume":"187","author":"R Zaynagetdinov","year":"2011","journal-title":"J Immunol"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1200\/JCO.2005.12.172","article-title":"Tumor-associated macrophages: the double-edged sword in cancer progression","volume":"23","author":"JJ Chen","year":"2005","journal-title":"J Clin Oncol"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"A Sica","year":"2012","journal-title":"J Clin Invest"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1158\/0008-5472.CAN-13-3118","article-title":"Tumor-infiltrating myeloid cells activate Dll4\/Notch\/TGF-beta signaling to drive malignant progression","volume":"74","author":"H Ohnuki","year":"2014","journal-title":"Cancer Res"},{"issue":"1","key":"ref33","first-page":"83","article-title":"Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome","volume":"152","author":"A Bellocq","year":"1998","journal-title":"Am J Pathol"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.4049\/jimmunol.181.9.5829","article-title":"Macrophages as APC and the dendritic cell myth","volume":"181","author":"DA Hume","year":"2008","journal-title":"J Immunol"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.4049\/jimmunol.178.5.2763","article-title":"Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage","volume":"178","author":"I Perrot","year":"2007","journal-title":"J Immunol"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ccr.2005.04.014","article-title":"De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent","volume":"7","author":"KE de Visser","year":"2005","journal-title":"Cancer Cell"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nri1572","article-title":"Regulation of plasma-cell development","volume":"5","author":"M Shapiro-Shelef","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.canlet.2013.01.036","article-title":"The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer","volume":"333","author":"M Lohr","year":"2013","journal-title":"Cancer Lett"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.humpath.2013.01.002","article-title":"Stromal plasma cells expressing immunoglobulin G4 subclass in non-small cell lung cancer","volume":"44","author":"M Fujimoto","year":"2013","journal-title":"Hum Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","article-title":"The PD-1 pathway in tolerance and autoimmunity","volume":"236","author":"LM Francisco","year":"2010","journal-title":"Immunol Rev"},{"issue":"230","key":"ref41","doi-asserted-by":"crossref","first-page":"ra46","DOI":"10.1126\/scisignal.2002796","article-title":"Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation","volume":"5","author":"N Patsoukis","year":"2012","journal-title":"Sci Signal"},{"issue":"26","key":"ref42","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"SL Topalian","year":"2012","journal-title":"The New England journal of medicine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0139073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T06:19:57Z","timestamp":1540016397000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0139073"}},"subtitle":[],"editor":[{"given":"Gernot","family":"Zissel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0139073","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}