{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T04:11:32Z","timestamp":1748664692046,"version":"3.41.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0139093","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T18:06:25Z","timestamp":1443549985000},"page":"e0139093","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation"],"prefix":"10.1371","volume":"10","author":[{"given":"Ju-Hee","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jeong","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Eun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangmee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Chul","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyae Gyeong","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","article-title":"Skeletal remodeling in health and disease","volume":"13","author":"M Zaidi","year":"2008","journal-title":"Nat Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"MF Pittenger","year":"1999","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/283669a0","article-title":"Osteoclasts derived from haematopoietic stem cells","volume":"283","author":"P Ash","year":"1980","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.cellbio.042308.113308","article-title":"Genetic control of bone formation","volume":"25","author":"G Karsenty","year":"2009","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/157488806775269133","article-title":"The stem state: Mesenchymal plasticity as a paradigm","volume":"1","author":"D Zipori","year":"2006","journal-title":"Curr Stem Cell Res Ther"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: the diverse biology of PPARgamma","volume":"77","author":"P Tontonoz","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1172\/JCI119424","article-title":"Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids","volume":"99","author":"AJ Vidal-Puig","year":"1997","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1210\/jc.2006-2646","article-title":"The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial","volume":"92","author":"A Grey","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.2337\/dc06-2606","article-title":"Thiazolidinedione treatment decreases bone mineral density in type 2 diabetic men","volume":"30","author":"S Yaturu","year":"2007","journal-title":"Diabetes Care"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1210\/jc.2008-2157","article-title":"A cohort study of thiazolidinediones and fractures in older adults with diabetes","volume":"94","author":"DH Solomon","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/ncpendmet0920","article-title":"The effect of thiazolidinediones on BMD and osteoporosis","volume":"4","author":"AK Mcdonough","year":"2008","journal-title":"Nat Clin Prac Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI200419900","article-title":"PPARgamma insufficient enhances osteogenesis through osteoblast formation from bone marrow progenitors","volume":"113","author":"T Akune","year":"2004","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1097-2765(00)80209-9","article-title":"PPARgamma is required for placental, cardiac, and adipose tissue development","volume":"4","author":"Y Barak","year":"1999","journal-title":"Mol Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/stem.405","article-title":"A new concept underlying stem cell lineage skewing that explains the detrimental effects of thiazolidinedione on bone","volume":"28","author":"C Bruedigam","year":"2010","journal-title":"Stem cells"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/(SICI)1097-4644(19990901)74:3<357::AID-JCB5>3.0.CO;2-7","article-title":"Inhibition of Osf2\/Cbfa1 expression and terminal osteoblast differentiation by PPAR\u03b32","volume":"74","author":"B Lecka-Czernik","year":"1999","journal-title":"J Cell Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nm1672","article-title":"PPAR\u03b3 regulates osteoclastogenesis in mice","volume":"13","author":"Y Wan","year":"2007","journal-title":"Nat Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C.elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"AC Epstein","year":"2001","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A conserved family of prolyl-4-hydroxylases that modify HIF","volume":"294","author":"RK Bruick","year":"2001","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF\u03b1 to the von Hippel-Lindau ubiquitination complex by O2-regulated prolyl hydroxylation","volume":"292","author":"P Jaakkola","year":"2001","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: implication for O<sub>2<\/sub> sensing","volume":"292","author":"M Ivan","year":"2001","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1093\/emboj\/20.18.5197","article-title":"Independent function of two destruction domains in hypoxia-inducible factor chains activated by prolyl hydroxylation","volume":"20","author":"N Masson","year":"2001","journal-title":"EMBO J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1139\/o02-115","article-title":"Mammalian EGLN genes have distinct patterns of mRNA expression and regulation","volume":"80","author":"ME Lieb","year":"2002","journal-title":"Biochem Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"12410","DOI":"10.1074\/jbc.M608748200","article-title":"EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability","volume":"282","author":"J Fu","year":"2007","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.1074\/jbc.M109.078600","article-title":"Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kB-dependent pathway","volume":"285","author":"J Fu","year":"2010","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jcb.21083","article-title":"Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype","volume":"100","author":"R Irwin","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1074\/jbc.M113.493650","article-title":"The role of prolyl hydroxylase domain protein (PHD) during rosiglitazone-induced adipocyte differentiation","volume":"289","author":"J Kim","year":"2014","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0005-2760(96)00066-5","article-title":"The peroxisome proliferator-activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation","volume":"1302","author":"K Schoonjans","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/PPAR\/2006\/24502","article-title":"Diabetes, TZDs, and bone: a review of the clinical evidence","volume":"2006","author":"AV Schwartz","year":"2006","journal-title":"PPAR Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.trsl.2012.08.006","article-title":"The effects of thiazolidinedione on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated patients with type 2 diabetes","volume":"161","author":"GR Beck","year":"2013","journal-title":"Translational Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00223-004-0224-8","article-title":"Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone)","volume":"75","author":"V Sottile","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1677\/joe.1.05723","article-title":"Rosiglitazone impacts negatively on bone by promoting osteoblast\/osteocyte apoptosis","volume":"183","author":"MA Soroceanu","year":"2004","journal-title":"J Endocrinol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1210\/en.2003-0746","article-title":"Bone is a target for the antidiabetic compound rosiglitazone","volume":"145","author":"SO Rzonca","year":"2004","journal-title":"Endocrinology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1210\/en.2004-0735","article-title":"Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation","volume":"146","author":"AA Ali","year":"2005","journal-title":"Endocrinology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nm1672","article-title":"PPARgamma regulates osteoclastogenesis in mice","volume":"13","author":"Y Wan","year":"2007","journal-title":"Nat Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1210\/endo.143.6.8834","article-title":"Divergent effects of selective peroxisome proliferator-activated receptor-r2 ligands on adipocyte versus osteoblast differentiation","volume":"143","author":"B Lecka-Czernik","year":"2002","journal-title":"Endocrinology"},{"issue":"Pt2","key":"ref36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1242\/jcs.102.2.341","article-title":"Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures","volume":"102","author":"JN Beresford","year":"1992","journal-title":"J Cell Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0046483","article-title":"Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner","volume":"7","author":"M Wagegg","year":"2012","journal-title":"PLos One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-2184.2011.00747.x","article-title":"In vitro study of enhanced osteogenesis induced by HIF-1\u03b1 -transduced bone marrow stem cells","volume":"44","author":"D Zou","year":"2011","journal-title":"Cell Prof"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/physiolgenomics.00229.2010","article-title":"Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitin-mediated proteosomal degradation pathway","volume":"43","author":"W Xing","year":"2011","journal-title":"Physiol Genomics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation","volume":"89","author":"P Ducy","year":"1997","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.gene.2005.10.017","article-title":"Phophorylation, acetylation and ubiquitination: The molecular basis of Runx regulation","volume":"366","author":"SC Bae","year":"2006","journal-title":"Gene"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.biocel.2007.05.024","article-title":"Runx2: of bone and stretch","volume":"40","author":"PG Ziros","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1749-6632.2009.05238.x","article-title":"Role of HIF-1alpha in skeletal development","volume":"1192","author":"C Wan","year":"2010","journal-title":"Ann NY Acad Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.14712\/fb2011057040133","article-title":"Effect of PPAR\u03b3 agonist rosiglitazone on bone mineral density and serum adipokines in C57BL\/6 male mice","volume":"57","author":"PD Broulik","year":"2013","journal-title":"Folia Biologica (Praha)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12013-013-9780-8","article-title":"Prolyl hydroxylase inhibitors protect from the bone loss in ovariectomy rats by increasing bone vascularity","volume":"69","author":"X Liu","year":"2014","journal-title":"Cell Biochem Biophys"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0139093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:20:28Z","timestamp":1748640028000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0139093"}},"subtitle":[],"editor":[{"given":"Weiqing","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,29]]},"references-count":45,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0139093","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2015,9,29]]}}}