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World Health Organization: Antimicrobial resistance: global report on surveillance, 2014. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/drugresistance\/documents\/surveillancereport\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/drugresistance\/documents\/surveillancereport\/en\/<\/ext-link>"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00006454-199904000-00004","article-title":"A population-based study of antibiotic prescriptions for Danish children","volume":"18","author":"N Thrane","year":"1999","journal-title":"The pediatric infectious disease journal"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/jac\/dkg302","article-title":"Antibiotic prescriptions in children","volume":"52","author":"D Resi","year":"2003","journal-title":"Journal of antimicrobial chemotherapy"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/jac\/dkm032","article-title":"Age-and gender-specific antibacterial prescribing in Norway","volume":"59","author":"HS Blix","year":"2007","journal-title":"Journal of antimicrobial chemotherapy"},{"key":"ref5","unstructured":"NICE. National Institute for Health and Care Excellence: Prescribing of antibiotics for self-limiting respiratory tract infections in adult and children in primary care. 2008. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nice.org.uk\/guidance\/cg69\/resources\/cg69-respiratory-tract-infections-full-guideline3\" xlink:type=\"simple\">http:\/\/www.nice.org.uk\/guidance\/cg69\/resources\/cg69-respiratory-tract-infections-full-guideline3<\/ext-link>"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/jac\/dkh062","article-title":"Trends in prescribing antibiotics for children in Dutch general practice","volume":"53","author":"HB Otters","year":"2004","journal-title":"Journal of antimicrobial chemotherapy"},{"key":"ref7","unstructured":"AIFA. Italian Medicines Agency: &quot;Antibiotici s\u00ec, ma con cautela&quot;. 2008. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.agenziafarmaco.gov.it\/it\/content\/antibiotici-s%C3%AC-ma-con-cautela\" xlink:type=\"simple\">http:\/\/www.agenziafarmaco.gov.it\/it\/content\/antibiotici-s%C3%AC-ma-con-cautela<\/ext-link>"},{"key":"ref8","unstructured":"AIFA. Italian Medicines Agency: &quot;Antibiotici? Usali con cautela&quot;. 2009. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.agenziafarmaco.gov.it\/it\/content\/la-campagna-antibiotici-usali-con-cautela\" xlink:type=\"simple\">http:\/\/www.agenziafarmaco.gov.it\/it\/content\/la-campagna-antibiotici-usali-con-cautela<\/ext-link>"},{"key":"ref9","unstructured":"AIFA. Italian Medicines Agency: &quot;Antibiotici. Difendi la tua difesa. Usali con cautela&quot;. 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.agenziafarmaco.gov.it\/it\/content\/antibiotici-difendi-la-tua-difesa-usali-con-cautela-0\" xlink:type=\"simple\">http:\/\/www.agenziafarmaco.gov.it\/it\/content\/antibiotici-difendi-la-tua-difesa-usali-con-cautela-0<\/ext-link>"},{"key":"ref10","unstructured":"Control EC. ECDC SURVEILLANCE REPORT Surveillance of antimicrobial consumption in Europe. 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ecdc.europa.eu\/en\/publications\/Publications\/antimicrobial-consumption-europe-surveillance-2011.pdf\" xlink:type=\"simple\">http:\/\/www.ecdc.europa.eu\/en\/publications\/Publications\/antimicrobial-consumption-europe-surveillance-2011.pdf<\/ext-link>"},{"key":"ref11","unstructured":"AIFA. Italian Medicines Agency: &quot;Antibiotici? Usali solo quando necessario&quot;\u2014Campagna web di sensibilizzazione all\u2019 uso appropriato degli antibiotici (2012). 2012. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.agenziafarmaco.gov.it\/it\/content\/antibiotici-usali-solo-quando-necessario-campagna-web-di-sensibilizzazione-all%E2%80%99-uso-appropri\" xlink:type=\"simple\">http:\/\/www.agenziafarmaco.gov.it\/it\/content\/antibiotici-usali-solo-quando-necessario-campagna-web-di-sensibilizzazione-all%E2%80%99-uso-appropri<\/ext-link>"},{"key":"ref12","unstructured":"Region Sa. I rapporti sulla sorveglianza dell&apos;antibioticoresistenza e uso di antibiotici. 2014. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ausl.bologna.it\/pro\/agesr\/il-nuovo-rapporto-sulla-sorveglianza\" xlink:type=\"simple\">http:\/\/www.ausl.bologna.it\/pro\/agesr\/il-nuovo-rapporto-sulla-sorveglianza<\/ext-link>"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/jac\/dkf239","article-title":"Antibiotic prescribing in general practice: striking differences between Italy (Ravenna) and Denmark (Funen)","volume":"50","author":"A Vaccheri","year":"2002","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"ref14","unstructured":"ESAC-Net. 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Avalaible: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.iss.it\/binary\/pres\/cont\/osmed_2011.pdf\" xlink:type=\"simple\">http:\/\/www.iss.it\/binary\/pres\/cont\/osmed_2011.pdf<\/ext-link>"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clinthera.2011.02.001","article-title":"Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children","volume":"33","author":"E Chiappini","year":"2011","journal-title":"Clinical therapeutics"},{"issue":"10","key":"ref39","first-page":"1","article-title":"Update on the management of acute pharyngitis in children","volume":"37","author":"M Regoli","year":"2011","journal-title":"Ital J Pediatr"},{"issue":"2","key":"ref40","first-page":"76","article-title":"Le linee-guida su faringotonsillite e otite media acuta della Regione Emilia-Romagna","volume":"15","author":"S Di Mario","year":"2008","journal-title":"Quaderni acp"},{"key":"ref41","unstructured":"Maria Luisa Moro, A.P., Rossella Buttazzi, Carlo Gagliotti. 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