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Neurosci"},{"issue":"14","key":"ref87","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1158\/1078-0432.CCR-08-0145","article-title":"RLIP76 and Cancer","volume":"14","author":"S Awasthi","year":"2008","journal-title":"Clin Cancer Res"},{"issue":"6","key":"ref88","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ccr.2005.04.030","article-title":"Activation of RalA is critical for Ras-induced tumorigenesis of human cells","volume":"7","author":"KH Lim","year":"2005","journal-title":"Cancer Cell"},{"issue":"6","key":"ref89","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/ijc.24767","article-title":"Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer","volume":"126","author":"SS Singhal","year":"2010","journal-title":"Int J Cancer"},{"issue":"5","key":"ref90","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.bcp.2008.10.006","article-title":"RLIP76: A novel glutathione-conjugate and multi-drug transporter","volume":"77","author":"SS Singhal","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"ref91","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bcp.2005.05.005","article-title":"Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin","volume":"70","author":"SS Singhal","year":"2005","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"ref92","first-page":"1505","article-title":"Role of RLIP76 in doxorubicin resistance in lung cancer","volume":"34","author":"R Vatsyayan","year":"2009","journal-title":"Int J Oncol"},{"issue":"12","key":"ref93","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.bcp.2010.01.016","article-title":"RLIP76: a versatile transporter and an emerging target for cancer therapy","volume":"79","author":"R Vatsyayan","year":"2010","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"ref94","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2013.02.056","article-title":"Down-regulation of RalBP1 expression reduces seizure threshold and synaptic inhibition in mice","volume":"433","author":"YS Bae","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"ref95","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/01.RES.0000147310.18962.06","article-title":"Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac","volume":"95","author":"KG Birukov","year":"2004","journal-title":"Circ Res"},{"issue":"2","key":"ref96","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/bj20020950","article-title":"Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases","volume":"368","author":"D Zhao","year":"2002","journal-title":"Biochem J"},{"issue":"6","key":"ref97","doi-asserted-by":"crossref","first-page":"C1397","DOI":"10.1152\/ajpcell.00328.2002","article-title":"Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways","volume":"284","author":"D Zhao","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"issue":"19","key":"ref98","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.1073\/pnas.82.19.6455","article-title":"Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70","volume":"82","author":"C Hunt","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref99","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0959-440X(97)80058-9","article-title":"Searching for regulatory elements in human noncoding sequences","volume":"7","author":"L Duret","year":"1997","journal-title":"Curr Opin Struct Biol"},{"issue":"16","key":"ref100","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1093\/nar\/gnh119","article-title":"Multiplex mRNA assay using electrophoretic tags for high-throughput gene expression analysis","volume":"32","author":"H Tian","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"ref101","doi-asserted-by":"crossref","first-page":"e1003710","DOI":"10.1371\/journal.ppat.1003710","article-title":"Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes","volume":"9","author":"Z Ammar","year":"2013","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref102","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5698\/1535-7511-12.1.8","article-title":"Inflammation and epilepsy: the foundations for a new therapeutic approach in epilepsy?","volume":"12","author":"L Walker","year":"2012","journal-title":"Epilepsy Curr"},{"key":"ref103","article-title":"Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis","author":"JA Gorter","year":"2015","journal-title":"Epilepsy Behav"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neulet.2015.04.046","article-title":"Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures","volume":"597","author":"Bernardino TC de Souza","year":"2015","journal-title":"Neurosci Lett"},{"issue":"2","key":"ref105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/cns.12371","article-title":"Inflammation and epilepsy in the developing brain: clinical and experimental evidence","volume":"21","author":"N Dupuis","year":"2015","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"ref106","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001911","article-title":"Carbamazepine versus phenytoin monotherapy for epilepsy","author":"Smith C Tudur","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"ref107","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/phrs.1998.0309","article-title":"Effect of non-steroidal anti-inflammatory drugs on the anticonvulsive activity of valproate and diphenylhydantoin against maximal electroshock-induced seizures in mice","volume":"37","author":"R Kaminski","year":"1998","journal-title":"Pharmacol Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0139101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T10:55:49Z","timestamp":1718103349000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0139101"}},"subtitle":[],"editor":[{"given":"Robert 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