{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:25:29Z","timestamp":1789885529380,"version":"4.0.1"},"reference-count":107,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0139416","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T18:17:41Z","timestamp":1444328261000},"page":"e0139416","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":130,"title":["Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model"],"prefix":"10.1371","volume":"10","author":[{"given":"Xiao","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Minei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun S.","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/187153006777442332","article-title":"Epidemiology of severe sepsis around the world","volume":"6","author":"DC Angus","year":"2006","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"RC Bone","year":"1992","journal-title":"Chest"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/CCM.0b013e3181cb0cdc","article-title":"The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis","volume":"38","author":"MM Levy","journal-title":"Crit Care Med"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.amjmed.2007.01.035","article-title":"Sepsis","volume":"120","author":"JM O'Brien Jr.","year":"2007","journal-title":"The American journal of medicine"},{"issue":"9328","key":"ref5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(02)09459-X","article-title":"Association between mitochondrial dysfunction and severity and outcome of septic shock","volume":"360","author":"D Brealey","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/00005373-199703000-00023","article-title":"Evidence for early supply independent mitochondrial dysfunction in patients developing multiple organ failure after trauma","volume":"42","author":"CB Cairns","year":"1997","journal-title":"The Journal of trauma"},{"issue":"Suppl A","key":"ref7","doi-asserted-by":"crossref","first-page":"A31","DOI":"10.1253\/circj.CJ-08-0014","article-title":"Oxidative stress and mitochondrial DNA damage in heart failure","volume":"72","author":"H Tsutsui","year":"2008","journal-title":"Circ J"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.freeradbiomed.2005.02.014","article-title":"Mitochondrial dysfunction in cardiovascular disease","volume":"38","author":"SW Ballinger","year":"2005","journal-title":"Free radical biology & medicine"},{"issue":"20","key":"ref9","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1161\/hc4501.098944","article-title":"Mitochondrial abnormalities in tumor necrosis factor-alpha-induced heart failure are associated with impaired DNA repair activity","volume":"104","author":"YY Li","year":"2001","journal-title":"Circulation"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/nar\/gkp100","article-title":"Oxidative stress induces degradation of mitochondrial DNA","volume":"37","author":"I Shokolenko","year":"2009","journal-title":"Nucleic acids research"},{"issue":"7285","key":"ref11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Q Zhang","year":"2010","journal-title":"Nature"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/eji.201141436","article-title":"Mitochondria: Sovereign of inflammation?","volume":"41","author":"J Tschopp","year":"2011","journal-title":"Eur J Immunol"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.it.2011.01.005","article-title":"Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation","volume":"32","author":"DV Krysko","year":"2011","journal-title":"Trends Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1749-6632.2010.05559.x","article-title":"Redox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular disease","volume":"1203","author":"JR Koenitzer","year":"2010","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2008.05.013","article-title":"Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box\u20131 protein","volume":"29","author":"H Kazama","year":"2008","journal-title":"Immunity"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1084\/jem.155.1.264","article-title":"Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils","volume":"155","author":"H Carp","year":"1982","journal-title":"The Journal of experimental medicine"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.exphem.2004.09.010","article-title":"Human platelets exhibit chemotaxis using functional N-formyl peptide receptors","volume":"33","author":"M Czapiga","year":"2005","journal-title":"Exp Hematol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1189\/jlb.0607-408","article-title":"Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like\u20131","volume":"83","author":"L Bjorkman","year":"2008","journal-title":"Journal of leukocyte biology"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/nm.2028","article-title":"Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors","volume":"15","author":"F Ghiringhelli","year":"2009","journal-title":"Nature medicine"},{"issue":"48","key":"ref20","doi-asserted-by":"crossref","first-page":"20388","DOI":"10.1073\/pnas.0908698106","article-title":"Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome","volume":"106","author":"SS Iyer","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/rheumatology\/keh406","article-title":"Extracellular cytochrome c, a mitochondrial apoptosis-related protein, induces arthritis","volume":"44","author":"R Pullerits","year":"2005","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10495-009-0412-0","article-title":"Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein\u20131","volume":"15","author":"R Codina","year":"2010","journal-title":"Apoptosis"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/sj.cdd.4401457","article-title":"Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis","volume":"11","author":"M Sorice","year":"2004","journal-title":"Cell death and differentiation"},{"issue":"6","key":"ref24","first-page":"533","article-title":"Release of the mitochondrial enzyme carbamoyl phosphate synthase under septic conditions","volume":"23","author":"J Struck","year":"2005","journal-title":"Shock"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s00134-010-1823-7","article-title":"Fall in circulating mononuclear cell mitochondrial DNA content in human sepsis","volume":"36","author":"A Pyle","year":"2010","journal-title":"Intensive care medicine"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1096\/fj.04-3500fje","article-title":"Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli","volume":"19","author":"HB Suliman","year":"2005","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"H1456","DOI":"10.1152\/ajpheart.00694.2005","article-title":"Neutrophil activation is modulated by sex hormones after trauma-hemorrhagic shock and burn injuries","volume":"291","author":"EA Deitch","year":"2006","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"e1001577","DOI":"10.1371\/journal.pmed.1001577","article-title":"Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation","volume":"10","author":"K Nakahira","year":"2013","journal-title":"PLoS medicine"},{"issue":"16","key":"ref29","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1073\/pnas.161293498","article-title":"Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition","volume":"98","author":"S Bauer","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6813","key":"ref30","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"H Hemmi","year":"2000","journal-title":"Nature"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4049\/jimmunol.1101375","article-title":"Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA","volume":"189","author":"MW Julian","year":"2012","journal-title":"J Immunol"},{"issue":"5008","key":"ref32","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.2035027","article-title":"Similarity of human mitochondrial transcription factor 1 to high mobility group proteins","volume":"252","author":"MA Parisi","year":"1991","journal-title":"Science"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/ni1457","article-title":"Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE","volume":"8","author":"J Tian","year":"2007","journal-title":"Nature immunology"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"e72354","DOI":"10.1371\/journal.pone.0072354","article-title":"Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha release via RAGE- and TLR9-responsive plasmacytoid dendritic cells","volume":"8","author":"MW Julian","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/cc1822","article-title":"Clinical review: Myocardial depression in sepsis and septic shock","volume":"6","author":"O Court","year":"2002","journal-title":"Crit Care"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/MCC.0b013e3283307a4e","article-title":"Cardiac dysfunction in severe sepsis and septic shock","volume":"15","author":"SL Zanotti-Cavazzoni","year":"2009","journal-title":"Curr Opin Crit Care"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/01.CCM.0000266683.64081.02","article-title":"Mechanisms of sepsis-induced cardiac dysfunction","volume":"35","author":"A Rudiger","year":"2007","journal-title":"Critical care medicine"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/cc7157","article-title":"Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study","volume":"12","author":"J Blanco","year":"2008","journal-title":"Crit Care"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.7326\/0003-4819-113-3-227","article-title":"Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy","volume":"113","author":"JE Parrillo","year":"1990","journal-title":"Annals of internal medicine"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0034-5687(87)90010-7","article-title":"Volume density and distribution of mitochondria in myocardial growth and hypertrophy","volume":"70","author":"SR Kayar","year":"1987","journal-title":"Respir Physiol"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/BCR.0b013e3181599bc9","article-title":"American Burn Association consensus conference to define sepsis and infection in burns","volume":"28","author":"DG Greenhalgh","year":"2007","journal-title":"J Burn Care Res"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.burns.2009.02.019","article-title":"Age-dependent differences of interleukin\u20136 activity in cardiac function after burn complicated by sepsis","volume":"36","author":"L Wang","year":"2010","journal-title":"Burns"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/jsre.1998.5352","article-title":"Aspiration pneumonia-induced sepsis increases cardiac dysfunction after burn trauma","volume":"76","author":"PW Sheeran","year":"1998","journal-title":"The Journal of surgical research"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"H47","DOI":"10.1152\/ajpheart.00833.2002","article-title":"Cardiac effects of burn injury complicated by aspiration pneumonia-induced sepsis","volume":"285","author":"J White","year":"2003","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/01.shk.0000183431.78973.cd","article-title":"Murine in vivo myocardial contractile dysfunction after burn injury is exacerbated by pneumonia sepsis","volume":"24","author":"W Tao","year":"2005","journal-title":"Shock"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/sur.2006.033","article-title":"Cardiac mitochondrial damage and inflammation responses in sepsis","volume":"8","author":"Q Zang","year":"2007","journal-title":"Surg Infect (Larchmt)"},{"issue":"9","key":"ref47","doi-asserted-by":"crossref","first-page":"H1847","DOI":"10.1152\/ajpheart.00203.2011","article-title":"Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model","volume":"302","author":"QS Zang","year":"2012","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"e43424","DOI":"10.1371\/journal.pone.0043424","article-title":"Sepsis-Induced Cardiac Mitochondrial Dysfunction Involves Altered Mitochondrial-Localization of Tyrosine Kinase Src and Tyrosine Phosphatase SHP2","volume":"7","author":"QS Zang","year":"2012","journal-title":"PloS one"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1073\/pnas.0931245100","article-title":"Delivery of bioactive molecules to mitochondria in vivo","volume":"100","author":"RA Smith","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1161\/hs1001.097099","article-title":"Reduction and restoration of mitochondrial dna content after focal cerebral ischemia\/reperfusion","volume":"32","author":"H Chen","year":"2001","journal-title":"Stroke; a journal of cerebral circulation"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"H882","DOI":"10.1152\/ajpheart.00475.2013","article-title":"Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs","volume":"306","author":"X Yao","year":"2014","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"H1951","DOI":"10.1152\/ajpheart.00927.2009","article-title":"Burn serum causes a CD14-dependent mitochondrial damage in primary cardiomyocytes","volume":"298","author":"QS Zang","year":"2010","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"3","key":"ref53","first-page":"227","article-title":"Assay for the intactness of the outer membrane in isolated mitochondria","volume":"19","author":"L Wojtczak","year":"1972","journal-title":"Acta Biochim Pol"},{"issue":"9","key":"ref54","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/nprot.2007.327","article-title":"Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy","volume":"2","author":"P Mukhopadhyay","year":"2007","journal-title":"Nat Protoc"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.critrevonc.2007.01.006","article-title":"Vascular endothelial growth factor (VEGF) signaling in tumor progression","volume":"62","author":"R Roskoski Jr","year":"2007","journal-title":"Critical reviews in oncology\/hematology"},{"issue":"10","key":"ref56","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrm3439","article-title":"Minimizing the damage: repair pathways keep mitochondrial DNA intact","volume":"13","author":"L Kazak","year":"2012","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/bmb\/ldt017","article-title":"Mitochondrial genetics","volume":"106","author":"PF Chinnery","year":"2013","journal-title":"British medical bulletin"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1083\/jcb.8.3.575","article-title":"Identification of glycogen in electron micrographs of thin tissue sections","volume":"8","author":"JP Revel","year":"1960","journal-title":"J Biophys Biochem Cytol"},{"issue":"42","key":"ref59","doi-asserted-by":"crossref","first-page":"12996","DOI":"10.1021\/bi000884z","article-title":"Detergent-solubilized bovine cytochrome c oxidase: dimerization depends on the amphiphilic environment","volume":"39","author":"A Musatov","year":"2000","journal-title":"Biochemistry"},{"issue":"8","key":"ref60","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1172\/JCI37607","article-title":"The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice","volume":"119","author":"J Zhu","year":"2009","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/bph.12530","article-title":"TLR9 and MyD88 are crucial for the maturation and activation of dendritic cells by paromomycin-miltefosine combination therapy in visceral leishmaniasis","volume":"171","author":"S Das","year":"2014","journal-title":"British journal of pharmacology"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.immuni.2005.09.016","article-title":"Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha\/beta and -lambda Is IRAK\u20134 dependent and redundant for protective immunity to viruses","volume":"23","author":"K Yang","year":"2005","journal-title":"Immunity"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1084\/jem.20120201","article-title":"RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA","volume":"210","author":"CM Sirois","year":"2013","journal-title":"The Journal of experimental medicine"},{"issue":"7","key":"ref64","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.2337\/db07-0326","article-title":"RAGE and modulation of ischemic injury in the diabetic myocardium","volume":"57","author":"LG Bucciarelli","year":"2008","journal-title":"Diabetes"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.exger.2003.12.006","article-title":"Age associated changes of AGE-receptor expression: RAGE upregulation is associated with human heart dysfunction","volume":"39","author":"A Simm","year":"2004","journal-title":"Experimental gerontology"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3892\/ol.2011.459","article-title":"High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues","volume":"3","author":"J Todorova","year":"2012","journal-title":"Oncology letters"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"L Agostini","year":"2004","journal-title":"Immunity"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of Nod-like receptors in microbial recognition and host defense","volume":"227","author":"L Franchi","year":"2009","journal-title":"Immunological reviews"},{"issue":"12","key":"ref69","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.amjmed.2013.06.029","article-title":"Elevated cardiac troponin T levels in critically ill patients with sepsis","volume":"126","author":"VC Vasile","year":"2013","journal-title":"The American journal of medicine"},{"issue":"2","key":"ref70","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/01.CCM.0000254349.10953.BE","article-title":"Cardiac troponins in the intensive care unit: common causes of increased levels and interpretation","volume":"35","author":"RE Fromm Jr","year":"2007","journal-title":"Critical care medicine"},{"issue":"7397","key":"ref71","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"T Oka","year":"2012","journal-title":"Nature"},{"issue":"3\u20136","key":"ref72","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0921-8734(92)90021-G","article-title":"Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease","volume":"275","author":"M Corral-Debrinski","year":"1992","journal-title":"Mutation research"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0002-9440(10)65738-0","article-title":"Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy","volume":"153","author":"E Arbustini","year":"1998","journal-title":"The American journal of pathology"},{"issue":"4","key":"ref74","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.CIR.91.4.955","article-title":"Cardiac involvement in mitochondrial diseases. A study on 17 patients with documented mitochondrial DNA defects","volume":"91","author":"R Anan","year":"1995","journal-title":"Circulation"},{"issue":"5","key":"ref75","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.RES.88.5.529","article-title":"Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction","volume":"88","author":"T Ide","year":"2001","journal-title":"Circulation research"},{"issue":"38","key":"ref76","doi-asserted-by":"crossref","first-page":"36027","DOI":"10.1074\/jbc.M304854200","article-title":"Production of reactive oxygen species by mitochondria: central role of complex III","volume":"278","author":"Q Chen","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"13","key":"ref77","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1093\/nar\/gkf392","article-title":"The mitochondrial DNA polymerase as a target of oxidative damage","volume":"30","author":"MA Graziewicz","year":"2002","journal-title":"Nucleic acids research"},{"issue":"6","key":"ref78","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/SHK.0b013e318235805f","article-title":"In vivo Toll-like receptor 4 antagonism restores cardiac function during endotoxemia","volume":"36","author":"S Ehrentraut","year":"2011","journal-title":"Shock"},{"issue":"3","key":"ref79","doi-asserted-by":"crossref","first-page":"H984","DOI":"10.1152\/ajpheart.01109.2009","article-title":"TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism","volume":"298","author":"T Ha","year":"2010","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"7","key":"ref80","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1172\/JCI19960","article-title":"Finding NEMO: genetic disorders of NF-[kappa]B activation","volume":"112","author":"JS Orange","year":"2003","journal-title":"J Clin Invest"},{"issue":"4","key":"ref81","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0962-8924(00)01729-3","article-title":"The IKK complex: an integrator of all signals that activate NF-kappaB?","volume":"10","author":"A Israel","year":"2000","journal-title":"Trends Cell Biol"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/CCM.0b013e31819267fb","article-title":"Molecular biology of inflammation and sepsis: a primer","volume":"37","author":"I Cinel","year":"2009","journal-title":"Critical care medicine"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"F Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1146\/annurev.biochem.76.060605.122847","article-title":"Signaling pathways downstream of pattern-recognition receptors and their cross talk","volume":"76","author":"MS Lee","year":"2007","journal-title":"Annu Rev Biochem"},{"issue":"7","key":"ref85","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.4049\/jimmunol.177.7.4853","article-title":"Caveolin\u20131 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide","volume":"177","author":"S Garrean","year":"2006","journal-title":"J Immunol"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jss.2013.02.045","article-title":"Rac1 signaling regulates sepsis-induced pathologic inflammation in the lung via attenuation of Mac\u20131 expression and CXC chemokine formation","volume":"183","author":"R Hwaiz","year":"2013","journal-title":"The Journal of surgical research"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"261049","DOI":"10.1155\/2013\/261049","article-title":"Toll-like receptor 9 promotes cardiac inflammation and heart failure during polymicrobial sepsis","volume":"2013","author":"R Lohner","year":"2013","journal-title":"Mediators of inflammation"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/2193-1801-3-207","article-title":"Association of inflammatory and endothelial cell activation biomarkers with acute kidney injury after sepsis","volume":"3","author":"TC Powell","year":"2014","journal-title":"SpringerPlus"},{"issue":"1","key":"ref89","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2353\/ajpath.2007.061099","article-title":"CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL","volume":"171","author":"DE Wesche-Soldato","year":"2007","journal-title":"The American journal of pathology"},{"issue":"4","key":"ref90","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/10715760902736275","article-title":"The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells","volume":"43","author":"DA Lowes","year":"2009","journal-title":"Free radical research"},{"issue":"36","key":"ref91","doi-asserted-by":"crossref","first-page":"37575","DOI":"10.1074\/jbc.M404003200","article-title":"Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis","volume":"279","author":"A Dhanasekaran","year":"2004","journal-title":"J Biol Chem"},{"issue":"5","key":"ref92","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2005.04.016","article-title":"Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide","volume":"39","author":"A Dhanasekaran","year":"2005","journal-title":"Free Radic Biol Med"},{"issue":"13","key":"ref93","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1096\/fj.03-0240fje","article-title":"Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants","volume":"17","author":"ML Jauslin","year":"2003","journal-title":"FASEB J"},{"issue":"11","key":"ref94","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.freeradbiomed.2010.08.028","article-title":"Neuroprotection by a mitochondria-targeted drug in a Parkinson&apos;s disease model","volume":"49","author":"A Ghosh","year":"2010","journal-title":"Free radical biology & medicine"},{"issue":"Suppl 2","key":"ref95","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","article-title":"Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer&apos;s disease neurons","volume":"20","author":"M Manczak","year":"2010","journal-title":"Journal of Alzheimer's disease: JAD"},{"issue":"4","key":"ref96","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.bpj.2008.10.042","article-title":"Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q","volume":"96","author":"K Chandran","year":"2009","journal-title":"Biophys J"},{"issue":"9","key":"ref97","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.05-3718com","article-title":"Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury","volume":"19","author":"VJ Adlam","year":"2005","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"1","key":"ref98","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.109.214601","article-title":"Therapeutic targeting of mitochondrial superoxide in hypertension","volume":"107","author":"AE Dikalova","journal-title":"Circulation research"},{"issue":"1","key":"ref99","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/BJ20100308","article-title":"Prevention of diabetic nephropathy in Ins2(+\/)(AkitaJ) mice by the mitochondria-targeted therapy MitoQ","volume":"432","author":"BK Chacko","year":"2010","journal-title":"The Biochemical journal"},{"issue":"11","key":"ref100","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.freeradbiomed.2008.09.003","article-title":"The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis","volume":"45","author":"DA Lowes","year":"2008","journal-title":"Free radical biology & medicine"},{"issue":"4","key":"ref101","doi-asserted-by":"crossref","first-page":"R1095","DOI":"10.1152\/ajpregu.90902.2008","article-title":"MitoQ administration prevents endotoxin-induced cardiac dysfunction","volume":"297","author":"GS Supinski","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"ref102","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/CIRCULATIONAHA.106.678359","article-title":"Sepsis and the heart","volume":"116","author":"MW Merx","year":"2007","journal-title":"Circulation"},{"issue":"2","key":"ref103","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI76887","article-title":"The HMGB1\/RAGE axis triggers neutrophil-mediated injury amplification following necrosis","volume":"125","author":"P Huebener","year":"2015","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref104","doi-asserted-by":"crossref","first-page":"R253","DOI":"10.1186\/cc13080","article-title":"Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome","volume":"17","author":"LB Ware","year":"2013","journal-title":"Crit Care"},{"key":"ref105","article-title":"Role of the NLRP3 inflammasome in acute kidney injury","author":"Y Cao","year":"2015","journal-title":"FEBS J"},{"issue":"6","key":"ref106","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jcrc.2013.05.006","article-title":"Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status","volume":"28","author":"S Yamanouchi","year":"2013","journal-title":"Journal of critical care"},{"issue":"3","key":"ref107","doi-asserted-by":"crossref","first-page":"e59989","DOI":"10.1371\/journal.pone.0059989","article-title":"Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways","volume":"8","author":"S Sun","year":"2013","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0139416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T09:47:26Z","timestamp":1567244846000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0139416"}},"subtitle":[],"editor":[{"given":"Elliott D.","family":"Crouser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":107,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0139416","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]}}}