{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:20:42Z","timestamp":1778635242395,"version":"3.51.4"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0139712","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T18:04:33Z","timestamp":1443722673000},"page":"e0139712","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Decreased Yes-Associated Protein-1 (YAP1) Expression in Pediatric Hearts with Ventricular Septal Defects"],"prefix":"10.1371","volume":"10","author":[{"given":"Lincai","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2174\/1389202915666140716175634","article-title":"Congenital Heart Disease: The Crossroads of Genetics, Epigenetics and Environment","volume":"15","author":"C Vecoli","year":"2014","journal-title":"Curr Genomics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/CIRCRESAHA.113.303060","article-title":"Bruneau, Deepak Srivastava. Congenital Heart Disease: Entering a New Era of Human Genetics","volume":"114","author":"G Benoit","year":"2014","journal-title":"Circ Res"},{"issue":"7453","key":"ref3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature12141","article-title":"De novo mutations in histone-modifying genes in congenital heart disease","volume":"498","author":"S Zaidi","year":"2013","journal-title":"Nature"},{"issue":"21","key":"ref4","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1242\/dev.052001","article-title":"Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes","volume":"137","author":"H Yu","year":"2010","journal-title":"Development"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"18681","DOI":"10.1074\/jbc.M114.554584","article-title":"Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion","volume":"289","author":"H Zhang","year":"2014","journal-title":"J. Biol. Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1073\/pnas.1116136109","article-title":"YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy","volume":"109","author":"A von Gise","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"D Pan","year":"2010","journal-title":"Dev Cell"},{"issue":"19","key":"ref8","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1101\/gad.1124803","article-title":"An essential role of Bmp4 in the atrioventricular septation of the mouse heart","volume":"17","author":"K Jiao","year":"2003","journal-title":"Genes Dev"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/dbio.2000.0106","article-title":"Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo","volume":"230","author":"YY Kisanuki","year":"2001","journal-title":"Dev Biol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"e54211","DOI":"10.1371\/journal.pone.0054211","article-title":"TAZ expression as a prognostic indicator in colorectal cancer","volume":"8","author":"HF Yuen","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ajpath.2013.12.017","article-title":"Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation","volume":"184","author":"T Quan","year":"2014","journal-title":"Am J Pathol"},{"issue":"337","key":"ref12","doi-asserted-by":"crossref","first-page":"re4","DOI":"10.1126\/scisignal.2005096","article-title":"The Hippo signal transduction network in skeletal and cardiac muscle","volume":"7","author":"H Wackerhage","year":"2014","journal-title":"Sci Signal"},{"key":"ref13","first-page":"311","article-title":"Pediatric Cardiac Surgery","author":"Mavroudis Constantine","year":"2013"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1242\/dev.02772","article-title":"Tissue\/planar cell polarity in vertebrates: new insights and new questions","volume":"134","author":"Y Wang","year":"2007","journal-title":"Development"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/ncb2303","article-title":"The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal","volume":"13","author":"B Zhao","year":"2011","journal-title":"Nat Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"M Xin","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/CIRCRESAHA.110.223024","article-title":"Cardiomyogenesis in the adult human heart","volume":"107","author":"J Kajstura","year":"2010","journal-title":"Circulation Research"},{"issue":"5923","key":"ref18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"O Bergmann","year":"2009","journal-title":"Science"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1073\/pnas.1214608110","article-title":"Cardiomyocyte proliferation contributes to heart growth in young humans","volume":"110","author":"M Mollova","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1038\/ncomms7085","article-title":"Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating","volume":"6","author":"K Dasbiswas","year":"2015","journal-title":"Nat Commun"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/archpedi.1973.04160020028005","article-title":"Spontaneous closure of small ventricular septal defects. probability rates in the first five years of life","volume":"125","author":"BS Alpert","year":"1973","journal-title":"Am J Dis Child"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1073\/pnas.1311705111","article-title":"Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration","volume":"111","author":"L Zhao","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1093\/eurheartj\/ehs269","article-title":"The Notch pathway controls fibrotic and regenerative repair in the adult heart","volume":"35","author":"M Nemir","year":"2014","journal-title":"European Heart Journal"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size","volume":"332","author":"T Heallen","year":"2011","journal-title":"Science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0139712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T12:29:09Z","timestamp":1540038549000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0139712"}},"subtitle":[],"editor":[{"given":"Neil A.","family":"Bhowmick","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,1]]},"references-count":24,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0139712","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,1]]}}}