{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:30:11Z","timestamp":1791433811141,"version":"4.3.3"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0139916","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T18:07:07Z","timestamp":1444932427000},"page":"e0139916","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Alum Adjuvant Enhances Protection against Respiratory Syncytial Virus but Exacerbates Pulmonary Inflammation by Modulating Multiple Innate and Adaptive Immune Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Ki-Hye","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Tae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Suk","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Man","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youri","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Na","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soojin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Moo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"issue":"9725","key":"ref1","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","article-title":"Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis","volume":"375","author":"H Nair","year":"2010","journal-title":"Lancet"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa043951","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults","volume":"352","author":"AR Falsey","year":"2005","journal-title":"The New England journal of medicine"},{"issue":"Pt 4","key":"ref3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1099\/0022-1317-67-4-623","article-title":"Murine cytotoxic T cells specific to respiratory syncytial virus recognize different antigenic subtypes of the virus","volume":"67","author":"CR Bangham","year":"1986","journal-title":"J Gen Virol"},{"issue":"1","key":"ref4","first-page":"37","article-title":"Passively acquired antibodies to respiratory syncytial virus impair the secondary cytotoxic T-cell response in the neonatal mouse","volume":"59","author":"CR Bangham","year":"1986","journal-title":"Immunology"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1084\/jem.179.1.81","article-title":"Distinct types of lung disease caused by functional subsets of antiviral T cells","volume":"179","author":"WH Alwan","year":"1994","journal-title":"J Exp Med"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1172\/JCI117546","article-title":"Anti-IL-4 treatment at immunization modulates cytokine expression, reduces illness, and increases cytotoxic T lymphocyte activity in mice challenged with respiratory syncytial virus","volume":"94","author":"YW Tang","year":"1994","journal-title":"J Clin Invest"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2249.2007.03341.x","article-title":"Respiratory syncytial virus replication is prolonged by a concomitant allergic response","volume":"148","author":"A Hassantoufighi","year":"2007","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.4049\/jimmunol.164.7.3487","article-title":"IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity in vivo","volume":"164","author":"S Aung","year":"2000","journal-title":"Journal of immunology"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1128\/JVI.75.3.1205-1210.2001","article-title":"Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox","volume":"75","author":"RJ Jackson","year":"2001","journal-title":"J Virol"},{"issue":"20","key":"ref10","doi-asserted-by":"crossref","first-page":"13020","DOI":"10.1073\/pnas.192251199","article-title":"A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte\/macrophage colony-stimulating factor and CD40L","volume":"99","author":"JD Ahlers","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"ref11","doi-asserted-by":"crossref","first-page":"10203","DOI":"10.1128\/JVI.76.20.10203-10210.2002","article-title":"Gamma interferon-dependent protection of the mouse upper respiratory tract following parenteral immunization with a respiratory syncytial virus G protein fragment","volume":"76","author":"H Plotnicky-Gilquin","year":"2002","journal-title":"J Virol"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.4049\/jimmunol.180.4.2376","article-title":"IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease","volume":"180","author":"EM Castilow","year":"2008","journal-title":"Journal of immunology"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1089\/vim.2009.0016","article-title":"Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease","volume":"22","author":"WW Stevens","year":"2009","journal-title":"Viral Immunol"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/oxfordjournals.aje.a120954","article-title":"An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine","volume":"89","author":"AZ Kapikian","year":"1969","journal-title":"American journal of epidemiology"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1128\/JVI.68.8.5321-5325.1994","article-title":"Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB\/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10","volume":"68","author":"M Connors","year":"1994","journal-title":"J Virol"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1128\/JVI.66.12.7444-7451.1992","article-title":"Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB\/c mice is abrogated by depletion of CD4+ T cells","volume":"66","author":"M Connors","year":"1992","journal-title":"J Virol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.4049\/jimmunol.151.4.2032","article-title":"Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus","volume":"151","author":"BS Graham","year":"1993","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fimmu.2013.00114","article-title":"Mechanisms of action of adjuvants","volume":"4","author":"S Awate","year":"2013","journal-title":"Front Immunol"},{"issue":"5678","key":"ref19","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.1089926","article-title":"Promotion of B cell immune responses via an alum-induced myeloid cell population","volume":"304","author":"MB Jordan","year":"2004","journal-title":"Science"},{"issue":"5807","key":"ref20","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1126\/science.1135299","article-title":"Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling","volume":"314","author":"AL Gavin","year":"2006","journal-title":"Science"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1084\/jem.20020073","article-title":"Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity","volume":"195","author":"A Bendelac","year":"2002","journal-title":"J Exp Med"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.4049\/jimmunol.163.12.6448","article-title":"Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling","volume":"163","author":"JM Brewer","year":"1999","journal-title":"J Immunol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4049\/jimmunol.159.2.591","article-title":"Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells","volume":"159","author":"KA Pape","year":"1997","journal-title":"J Immunol"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.4049\/jimmunol.181.6.3755","article-title":"Cutting Edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome","volume":"181","author":"M Kool","year":"2008","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-immunol-020711-075021","article-title":"Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology","volume":"30","author":"BN Lambrecht","year":"2012","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.4049\/jimmunol.164.6.2978","article-title":"CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen","volume":"164","author":"D Vremec","year":"2000","journal-title":"J Immunol"},{"issue":"5405","key":"ref27","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.283.5405.1183","article-title":"Reciprocal control of T helper cell and dendritic cell differentiation","volume":"283","author":"MC Rissoan","year":"1999","journal-title":"Science"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1073\/pnas.96.3.1036","article-title":"Distinct dendritic cell subsets differentially regulate the class of immune response in vivo","volume":"96","author":"B Pulendran","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"ref29","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1128\/JVI.00452-09","article-title":"Respiratory syncytial virus-induced activation and migration of respiratory dendritic cells and subsequent antigen presentation in the lung-draining lymph node","volume":"83","author":"MV Lukens","year":"2009","journal-title":"J Virol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2567.2007.02613.x","article-title":"Respiratory syncytial virus differentially activates murine myeloid and plasmacytoid dendritic cells","volume":"122","author":"I Boogaard","year":"2007","journal-title":"Immunology"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"e1720","DOI":"10.1371\/journal.pone.0001720","article-title":"The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections","volume":"3","author":"JJ Smit","year":"2008","journal-title":"PLoS One"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1086\/428589","article-title":"Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections","volume":"191","author":"MA Gill","year":"2005","journal-title":"J Infect Dis"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.4049\/jimmunol.0902984","article-title":"Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells","volume":"184","author":"RA Langlois","year":"2010","journal-title":"J Immunol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nm.1894","article-title":"Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease","volume":"15","author":"MF Delgado","year":"2009","journal-title":"Nat Med"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1128\/JVI.01709-09","article-title":"Newcastle disease virus-like particles containing respiratory syncytial virus G protein induced protection in BALB\/c mice, with no evidence of immunopathology","volume":"84","author":"MR Murawski","year":"2010","journal-title":"J Virol"},{"issue":"13","key":"ref36","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.vaccine.2013.11.032","article-title":"A recombinant anchorless respiratory syncytial virus (RSV) fusion (F) protein\/monophosphoryl lipid A (MPL) vaccine protects against RSV-induced replication and lung pathology","volume":"32","author":"JC Blanco","year":"2014","journal-title":"Vaccine"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1084\/jem.20020781","article-title":"A role for immune complexes in enhanced respiratory syncytial virus disease","volume":"196","author":"FP Polack","year":"2002","journal-title":"J Exp Med"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/infdis\/jir474","article-title":"Viruslike particle vaccine induces protection against respiratory syncytial virus infection in mice","volume":"204","author":"FS Quan","year":"2011","journal-title":"J Infect Dis"},{"issue":"Pt 12","key":"ref39","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1099\/0022-1317-82-12-2881","article-title":"Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine","volume":"82","author":"GA Prince","year":"2001","journal-title":"J Gen Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2014.01.008","article-title":"Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease","volume":"104","author":"YM Kwon","year":"2014","journal-title":"Antiviral Res"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Hwang HS, Kwon YM, Lee JS, Yoo SE, Lee YN, Ko EJ, et al. Co-immunization with virus-like particle and DNA vaccines induces better protection than live virus against respiratory syncytial virus infection and pathology (revision). 2014.","DOI":"10.1016\/j.antiviral.2014.07.016"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.virol.2010.05.034","article-title":"Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles","volume":"405","author":"JM Song","year":"2010","journal-title":"Virology"},{"issue":"Pt 2","key":"ref43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1099\/0022-1317-83-2-429","article-title":"Virus-specific CTL responses induced by an H-2K(d)-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus","volume":"83","author":"S Jiang","year":"2002","journal-title":"J Gen Virol"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.4049\/jimmunol.165.11.6487","article-title":"The attachment (G) glycoprotein of respiratory syncytial virus contains a single immunodominant epitope that elicits both Th1 and Th2 CD4+ T cell responses","volume":"165","author":"SM Varga","year":"2000","journal-title":"Journal of immunology"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0192623308329342","article-title":"Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation model","volume":"37","author":"DK Meyerholz","year":"2009","journal-title":"Toxicol Pathol"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1128\/JVI.01693-10","article-title":"Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB\/c mice","volume":"85","author":"KL Stokes","year":"2011","journal-title":"J Virol"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1742-4933-9-21","article-title":"An adjuvanted respiratory syncytial virus fusion protein induces protection in aged BALB\/c mice","volume":"9","author":"A Cherukuri","year":"2012","journal-title":"Immun Ageing"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0167-5699(99)01547-9","article-title":"T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal","volume":"20","author":"P Kalinski","year":"1999","journal-title":"Immunology today"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"e36812","DOI":"10.1371\/journal.pone.0036812","article-title":"Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice","volume":"7","author":"T Kamphuis","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"ref50","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1128\/JVI.71.9.6935-6939.1997","article-title":"Priming with live respiratory syncytial virus (RSV) prevents the enhanced pulmonary inflammatory response seen after RSV challenge in BALB\/c mice immunized with formalin-inactivated RSV","volume":"71","author":"ME Waris","year":"1997","journal-title":"J Virol"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.4049\/jimmunol.170.4.2037","article-title":"IL-13 is sufficient for respiratory syncytial virus G glycoprotein-induced eosinophilia after respiratory syncytial virus challenge","volume":"170","author":"TR Johnson","year":"2003","journal-title":"J Immunol"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1189\/jlb.0907621","article-title":"Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein","volume":"84","author":"TR Johnson","year":"2008","journal-title":"J Leukoc Biol"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.vaccine.2004.05.015","article-title":"Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins","volume":"23","author":"W Olszewska","year":"2004","journal-title":"Vaccine"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI115362","article-title":"Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice","volume":"88","author":"BS Graham","year":"1991","journal-title":"J Clin Invest"},{"issue":"9","key":"ref55","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1002\/1521-4141(200209)32:9<2562::AID-IMMU2562>3.0.CO;2-4","article-title":"Pulmonary T cells induced by respiratory syncytial virus are functional and can make an important contribution to long-lived protective immunity","volume":"32","author":"T Ostler","year":"2002","journal-title":"Eur J Immunol"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.4049\/jimmunol.166.2.1106","article-title":"Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses","volume":"166","author":"CP Simmons","year":"2001","journal-title":"J Immunol"},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1586\/erv.12.117","article-title":"The role of dendritic cells in innate and adaptive immunity to respiratory syncytial virus, and implications for vaccine development","volume":"11","author":"R Garg","year":"2012","journal-title":"Expert review of vaccines"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1189\/jlb.0602289","article-title":"Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response","volume":"73","author":"AS Charbonnier","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1182\/blood.V98.4.1135","article-title":"Th2 polarization by Der p 1\u2014pulsed monocyte-derived dendritic cells is due to the allergic status of the donors","volume":"98","author":"H Hammad","year":"2001","journal-title":"Blood"},{"issue":"4","key":"ref60","first-page":"219","article-title":"Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC\/CCL17 and MDC\/CCL22","volume":"14","author":"H Hammad","year":"2003","journal-title":"Eur Cytokine Netw"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1084\/jem.189.3.587","article-title":"CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo","volume":"189","author":"R Maldonado-Lopez","year":"1999","journal-title":"J Exp Med"},{"issue":"9","key":"ref62","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.4049\/jimmunol.170.9.4457","article-title":"IL-6 production by pulmonary dendritic cells impedes Th1 immune responses","volume":"170","author":"IL Dodge","year":"2003","journal-title":"Journal of immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0139916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T11:22:28Z","timestamp":1692098548000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0139916"}},"subtitle":[],"editor":[{"given":"Gourapura J","family":"Renukaradhya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,15]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0139916","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,15]]}}}