{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:57:03Z","timestamp":1779353823517,"version":"3.51.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0140036","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T18:19:55Z","timestamp":1445019595000},"page":"e0140036","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature"],"prefix":"10.1371","volume":"10","author":[{"given":"Esther N.","family":"Pesciotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Sun","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Kossenkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise C.","family":"Showe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Bessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Speicher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1365-2141.2008.07269.x","article-title":"Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference","volume":"142","author":"A Vlachos","year":"2008","journal-title":"British Journal of Haematology"},{"key":"ref2","article-title":"Clinical utility gene card for: Diamond\u2014Blackfan anemia\u2014update 2013","author":"A Vlachos","year":"2013","journal-title":"Eur J Hum Genet"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.3324\/haematol.2012.062281","article-title":"High frequency of ribosomal protein gene deletions in Italian Diamond-Blackfan anemia patients detected by multiplex ligation-dependent probe amplification assay","volume":"97","author":"P Quarello","year":"2012","journal-title":"Haematologica"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1172\/JCI63597","article-title":"Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia","volume":"122","author":"VG Sankaran","year":"2012","journal-title":"J Clin Invest"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm.3557","article-title":"Altered translation of GATA1 in Diamond-Blackfan anemia","volume":"20","author":"LS Ludwig","year":"2014","journal-title":"Nat Med"},{"issue":"18","key":"ref6","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1182\/blood-2014-04-526301","article-title":"Marrow failure: a window into ribosome biology","volume":"124","author":"D Ruggero","year":"2014","journal-title":"Blood"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1586\/17474086.2014.897923","article-title":"Diamond Blackfan anemia: a model for the translational approach to understanding human disease","volume":"7","author":"A Vlachos","year":"2014","journal-title":"Expert Rev Hematol"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00043426-200108000-00015","article-title":"The Diamond Blackfan Anemia Registry: tool for investigating the epidemiology and biology of Diamond-Blackfan anemia","volume":"23","author":"A Vlachos","year":"2001","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"184362","DOI":"10.1100\/2012\/184362","article-title":"Progress towards mechanism-based treatment for Diamond-Blackfan anemia","volume":"2012","author":"SE Sjogren","year":"2012","journal-title":"ScientificWorldJournal"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"e85504","DOI":"10.1371\/journal.pone.0085504","article-title":"Dysferlin and other non-red cell proteins accumulate in the red cell membrane of Diamond-Blackfan Anemia patients","volume":"9","author":"EN Pesciotta","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood-2005-11-007799","article-title":"In-depth analysis of the membrane and cytosolic proteome of red blood cells","volume":"108","author":"EM Pasini","year":"2006","journal-title":"Blood"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1074\/mcp.M300132-MCP200","article-title":"The human erythrocyte proteome\u2014Analysis by ion trap mass spectrometry","volume":"3","author":"DG Kakhniashvili","year":"2004","journal-title":"Molecular & Cellular Proteomics"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/prca.200700178","article-title":"Hemoglobin depletion from red blood cell cytosol reveals new proteins in 2-D gel-based proteomics study","volume":"1","author":"D Bhattacharya","year":"2007","journal-title":"Proteomics Clin Appl"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1021\/pr060308a","article-title":"2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia","volume":"6","author":"S Prabakaran","year":"2007","journal-title":"J Proteome Res"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1021\/pr8001029","article-title":"Highly efficient depletion strategy for the two most abundant erythrocyte soluble proteins improves proteome coverage dramatically","volume":"7","author":"JH Ringrose","year":"2008","journal-title":"J Proteome Res"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1074\/mcp.M800037-MCP200","article-title":"Extensive analysis of the cytoplasmic proteome of human erythrocytes using the peptide ligand library technology and advanced mass spectrometry","volume":"7","author":"F Roux-Dalvai","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"ref17","article-title":"A label-free proteome analysis strategy for identifying quantitative changes in erythrocyte membranes induced by red cell disorders","author":"EN Pesciotta","year":"2012","journal-title":"Journal of Proteomics"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"J Cox","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"J Cox","year":"2011","journal-title":"J Proteome Res"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ","volume":"13","author":"J Cox","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"JA Vizcaino","year":"2014","journal-title":"Nat Biotechnol"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1021\/pr801085g","article-title":"Proteome Maps of the Main Human Peripheral Blood Constituents","volume":"8","author":"VJ Haudek","year":"2009","journal-title":"Journal of Proteome Research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1182\/asheducation-2011.1.487","article-title":"Diamond Blackfan anemia","volume":"2011","author":"S Ball","year":"2011","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/wrna.73","article-title":"Guarding the 'translation apparatus': defective ribosome biogenesis and the p53 signaling pathway","volume":"2","author":"A Chakraborty","year":"2011","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1007\/s00705-014-2147-7","article-title":"A critical role of interferon-induced protein IFP35 in the type I interferon response in cells induced by foot-and-mouth disease virus (FMDV) protein 2C","volume":"159","author":"W Zheng","year":"2014","journal-title":"Arch Virol"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1089\/107999002753536211","article-title":"Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells","volume":"22","author":"J Chen","year":"2002","journal-title":"J Interferon Cytokine Res"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2009.11.021","article-title":"Gene modulation and immunoregulatory roles of interferon gamma","volume":"50","author":"B Saha","year":"2010","journal-title":"Cytokine"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.coi.2012.11.004","article-title":"The immunoproteasome in antigen processing and other immunological functions","volume":"25","author":"M Basler","year":"2013","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2011.12.030","article-title":"Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity","volume":"148","author":"EM Huber","year":"2012","journal-title":"Cell"},{"issue":"40","key":"ref30","doi-asserted-by":"crossref","first-page":"23808","DOI":"10.1074\/jbc.270.40.23808","article-title":"The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2\/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro","volume":"270","author":"M Groettrup","year":"1995","journal-title":"J Biol Chem"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.194.1.1","article-title":"Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products","volume":"194","author":"RE Toes","year":"2001","journal-title":"J Exp Med"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2141.1990.tb02624.x","article-title":"HLA class I expression on erythrocytes and platelets from patients with systemic lupus erythematosus, rheumatoid arthritis and from normal subjects","volume":"75","author":"M Botto","year":"1990","journal-title":"Br J Haematol"},{"issue":"2","key":"ref33","first-page":"368","article-title":"Expression of MHC class I determinants on erythrocytes of SLE patients","volume":"69","author":"CM Giles","year":"1987","journal-title":"Clin Exp Immunol"},{"issue":"25","key":"ref34","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1182\/blood-2014-06-584656","article-title":"TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors","volume":"124","author":"E Bibikova","year":"2014","journal-title":"Blood"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.bcp.2008.08.025","article-title":"Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation","volume":"76","author":"I Buck","year":"2008","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"ref36","first-page":"853","article-title":"The inhibitory effect of the proinflammatory cytokine TNFalpha on erythroid differentiation involves erythroid transcription factor modulation","volume":"34","author":"I Buck","year":"2009","journal-title":"Int J Oncol"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood.V65.5.1056.1056","article-title":"Drug-induced endocytosis of neonatal erythrocytes","volume":"65","author":"LM Matovcik","year":"1985","journal-title":"Blood"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1634\/stemcells.2005-0554","article-title":"Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia","volume":"24","author":"HT Gazda","year":"2006","journal-title":"Stem Cells"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"e0134878","DOI":"10.1371\/journal.pone.0134878","article-title":"Dysregulation of the Transforming Growth Factor beta Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia","volume":"10","author":"J Ge","year":"2015","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-beta activation and function in immunity","volume":"32","author":"MA Travis","year":"2014","journal-title":"Annu Rev Immunol"},{"issue":"22","key":"ref41","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.2174\/1381612811319220018","article-title":"Inhibitors of the immunoproteasome: current status and future directions","volume":"19","author":"Z Miller","year":"2013","journal-title":"Curr Pharm Des"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0140036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T22:00:14Z","timestamp":1599688814000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0140036"}},"subtitle":[],"editor":[{"given":"Tracey","family":"Rouault","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,16]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0140036","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,16]]}}}