{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:10:36Z","timestamp":1767978636239,"version":"3.49.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0140168","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T18:12:37Z","timestamp":1444327957000},"page":"e0140168","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma"],"prefix":"10.1371","volume":"10","author":[{"given":"Magnus E.","family":"Jakobsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Moen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l \u00d8.","family":"Falnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrc3409","article-title":"Protein arginine methyltransferases and cancer","volume":"13","author":"Y Yang","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/msb.134974","article-title":"The functional diversity of protein lysine methylation","volume":"10","author":"S Lanouette","year":"2014","journal-title":"Mol Syst Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","article-title":"Histone lysine methylation dynamics: establishment, regulation, and biological impact","volume":"48","author":"JC Black","year":"2012","journal-title":"Mol Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.tibs.2013.09.004","article-title":"SET for life: biochemical activities and biological functions of SET domain-containing proteins","volume":"38","author":"HM Herz","year":"2013","journal-title":"Trends Biochem Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0960-9822(02)00901-6","article-title":"Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain","volume":"12","author":"Q Feng","year":"2002","journal-title":"Curr Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"M110","DOI":"10.1074\/mcp.M110.000976","article-title":"Uncovering the human methyltransferasome","volume":"10","author":"TC Petrossian","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"ref7","article-title":"Targeting histone lysine methylation in cancer","author":"J McGrath","year":"2015","journal-title":"Pharmacol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/onc.2012.552","article-title":"Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics","volume":"32","author":"RA Copeland","year":"2013","journal-title":"Oncogene"},{"key":"ref9","first-page":"75","article-title":"Histone lysine methylation and demethylation pathways in cancer","volume":"1815","author":"RA Varier","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1003210","DOI":"10.1371\/journal.pgen.1003210","article-title":"A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity","volume":"9","author":"P Cloutier","year":"2013","journal-title":"PLoS Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"30499","DOI":"10.1074\/jbc.M114.601658","article-title":"Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)","volume":"289","author":"E Davydova","year":"2014","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"27752","DOI":"10.1074\/jbc.M113.483248","article-title":"Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation","volume":"288","author":"ME Jakobsson","year":"2013","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/ncomms2041","article-title":"Lysine methylation of VCP by a member of a novel human protein methyltransferase family","volume":"3","author":"S Kernstock","year":"2012","journal-title":"Nat Commun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1074\/jbc.M114.614115","article-title":"Human METTL20 is a Mitochondrial Lysine Methyltransferase that Targets the Beta Subunit of Electron Transfer Flavoprotein (ETFbeta) and Modulates Its Activity","volume":"290","author":"J Malecki","year":"2014","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"24640","DOI":"10.1074\/jbc.M114.580464","article-title":"Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria","volume":"289","author":"VF Rhein","year":"2014","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/carcin\/bgt111","article-title":"The HSP70 family and cancer","volume":"34","author":"ME Murphy","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref17","article-title":"Hsp70 in cancer: back to the future","author":"MY Sherman","year":"2014","journal-title":"Oncogene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ncomms2074","article-title":"Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B","volume":"3","author":"HS Cho","year":"2012","journal-title":"Nat Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2303.2010.00829.x","article-title":"The diagnostic and molecular characteristics of malignant mesothelioma and ovarian\/peritoneal serous carcinoma","volume":"22","author":"B Davidson","year":"2011","journal-title":"Cytopathology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/00000478-200111000-00008","article-title":"The role of desmin and N-cadherin in effusion cytology: a comparative study using established markers of mesothelial and epithelial cells","volume":"25","author":"B Davidson","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1200\/JCO.1994.12.9.1748","article-title":"Phase II trial of paclitaxel in patients with progressive ovarian carcinoma after platinum-based chemotherapy: a Gynecologic Oncology Group study","volume":"12","author":"JT Thigpen","year":"1994","journal-title":"J Clin Oncol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada","volume":"92","author":"P Therasse","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/PGP.0b013e31818b0f5e","article-title":"Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma","volume":"28","author":"MB Elstrand","year":"2009","journal-title":"Int J Gynecol Pathol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature03117","article-title":"Regulation of p53 activity through lysine methylation","volume":"432","author":"S Chuikov","year":"2004","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/emboj.2010.311","article-title":"Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein","volume":"30","author":"SM Carr","year":"2011","journal-title":"EMBO J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature13320","article-title":"SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer","volume":"510","author":"PK Mazur","year":"2014","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3816\/CGC.2004.n.013","article-title":"Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer","volume":"3","author":"M Abe","year":"2004","journal-title":"Clin Prostate Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.cca.2012.03.008","article-title":"Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: a multi-institutional case-control study","volume":"413","author":"M Zimmermann","year":"2012","journal-title":"Clin Chim Acta"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/MPA.0b013e3182374ace","article-title":"Serum HSP70: a novel biomarker for early detection of pancreatic cancer","volume":"41","author":"SK Dutta","year":"2012","journal-title":"Pancreas"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0140168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:50:48Z","timestamp":1589010648000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0140168"}},"subtitle":[],"editor":[{"given":"Mary","family":"Bryk","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0140168","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]}}}