{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:21:35Z","timestamp":1790785295410,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0140316","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T18:18:05Z","timestamp":1444933085000},"page":"e0140316","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":71,"title":["Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse"],"prefix":"10.1371","volume":"10","author":[{"given":"Ken","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1161\/STROKEAHA.107.181486","article-title":"Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association\/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American educational tool for neurologists","volume":"38","author":"HP Adams Jr","year":"2007","journal-title":"Stroke"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1124\/jpet.108.149484","article-title":"The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells","volume":"329","author":"K Kikuchi","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbrc.2009.09.015","article-title":"Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4","volume":"390","author":"K Kikuchi","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/157489006775244191","article-title":"Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger for treatment of cardiovascular diseases","volume":"1","author":"Y Higashi","year":"2006","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3892\/etm.2011.281","article-title":"Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction","volume":"2","author":"K Kikuchi","year":"2011","journal-title":"Exp Ther Med"},{"issue":"7\u20138","key":"ref6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3109\/21678421.2014.959024","article-title":"Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients","volume":"15","author":"K Abe","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"ref7","first-page":"23","article-title":"Wobbler (wr)","volume":"15","author":"DS Falconer","year":"1956","journal-title":"Mouse News Lett"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/jnnp.31.6.535","article-title":"An hereditary motor neurone disease with progressive denervation of muscle in the mouse: the mutant &apos;wobbler&apos;","volume":"31","author":"LW Duchen","year":"1968","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Pt 4","key":"ref9","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/brain\/105.4.811","article-title":"Murine motor neuron disease (the wobbler mouse): degeneration and regeneration of the lower motor neuron","volume":"105","author":"H Mitsumoto","year":"1982","journal-title":"Brain"},{"issue":"5\u20136","key":"ref10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00438-013-0741-0","article-title":"The wobbler mouse, an ALS animal model","volume":"288","author":"JM Moser","year":"2013","journal-title":"Mol Genet Genomics"},{"issue":"5175","key":"ref11","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.8066451","article-title":"Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF","volume":"265","author":"H Mitsumoto","year":"1994","journal-title":"Science"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0960-8966(95)00003-6","article-title":"Lecithinized superoxide dismutase retards wobbler mouse motoneuron disease","volume":"5","author":"K Ikeda","year":"1995","journal-title":"Neuromuscul Disord"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ana.410370413","article-title":"Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease","volume":"37","author":"K Ikeda","year":"1995","journal-title":"Ann Neurol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-510X(98)00224-X","article-title":"Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse","volume":"160","author":"K Ikeda","year":"1998","journal-title":"J Neurol Sci"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/14660820050515205","article-title":"Oral administration of creatine monohydrate retards progression of motor neuron disease in the wobbler mouse","volume":"1","author":"K Ikeda","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0006-8993(99)02427-0","article-title":"T-588, a novel neuroprotective agent, delays progression of neuromuscular dysfunction in wobbler mouse motoneuron disease","volume":"858","author":"K Ikeda","year":"2000","journal-title":"Brain Res"},{"issue":"4","key":"ref17","first-page":"139","article-title":"Zonisamide treatment delays motor neuron degeneration and astrocyte proliferation in wobbler mice","volume":"1","author":"T Hirayama","year":"2011","journal-title":"J Neurology Res"},{"issue":"1\u20132","key":"ref18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jns.2015.04.052","article-title":"Neuroprotective effect of ultra-high dose methylcobalamin in wobbler mouse model of amyotrophic lateral sclerosis","volume":"354","author":"K Ikeda","year":"2015","journal-title":"J Neurol Sci"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1091\/mbc.E05-11-1002","article-title":"Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition","volume":"17","author":"NR Quenneville","year":"2006","journal-title":"Mol Biol Cell"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ng1001-160","article-title":"The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis","volume":"29","author":"Y Yang","year":"2001","journal-title":"Nat Genet"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"AL Nishimura","year":"2004","journal-title":"Am J Hum Genet"},{"issue":"7295","key":"ref22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature08971","article-title":"Mutations of optineurin in amyotrophic lateral sclerosis","volume":"465","author":"H Maruyama","year":"2010","journal-title":"Nature"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2010.11.036","article-title":"Exome sequencing reveals VCP mutations as a cause of familial ALS","volume":"68","author":"JO Johnson","year":"2010","journal-title":"Neuron"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1212\/01.wnl.0000231510.89311.8b","article-title":"ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)","volume":"67","author":"N Parkinson","year":"2006","journal-title":"Neurology"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neuroscience.2008.10.030","article-title":"Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein","volume":"158","author":"JS Dennis","year":"2009","journal-title":"Neuroscience"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.nbd.2013.10.010","article-title":"Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation","volume":"62","author":"M Peviani","year":"2014","journal-title":"Neurobiol Dis"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.expneurol.2008.07.017","article-title":"Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice","volume":"213","author":"H Ito","year":"2008","journal-title":"Exp Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.brainres.2011.01.058","article-title":"Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger","volume":"1382","author":"M Aoki","year":"2011","journal-title":"Brain Res"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2176\/nmc.48.539","article-title":"Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model","volume":"48","author":"T Aoyama","year":"2008","journal-title":"Neurol Med Chir"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.jtcvs.2005.08.049","article-title":"Experimental study on the protective effects of edaravone against ischemic spinal cord injury","volume":"130","author":"K Suzuki","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0022-5223(03)00693-7","article-title":"MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu\/Zn superoxide dismutase after transient ischemia in rabbits","volume":"126","author":"G Takahashi","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S1474-4422(14)70129-2","article-title":"Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?","volume":"13","author":"H Mitsumoto","year":"2014","journal-title":"Lancet Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0140316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T16:01:21Z","timestamp":1567267281000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0140316"}},"subtitle":[],"editor":[{"given":"Andrew James","family":"Grierson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,15]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0140316","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,15]]}}}