{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:10:41Z","timestamp":1762431041819},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0140367","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T20:17:19Z","timestamp":1445631439000},"page":"e0140367","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Proteomic and Metabolomic Analyses Reveal Contrasting Anti-Inflammatory Effects of an Extract of Mucor Racemosus Secondary Metabolites Compared to Dexamethasone"],"prefix":"10.1371","volume":"10","author":[{"given":"Samuel M.","family":"Meier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Besnik","family":"Muqaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Ullmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bileck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Kreutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna C.","family":"Mader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Knasm\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Gerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nmeth872","article-title":"Fluorescent Cell Barcoding in Flow Cytometry Allows High-Throughput Drug Screening and Signaling Profiling","volume":"3","author":"PO Krutzik","year":"2006","journal-title":"Nat Methods"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0140-6736(14)60648-6","article-title":"Prevention of Chronic Disease in the 21st Century: Elimination of the Leading Preventable Causes of Premature Death and Disability in the USA","volume":"384","author":"UE Bauer","year":"2014","journal-title":"Lancet"},{"key":"ref3","first-page":"190","article-title":"Consideration of the Cellular Microenvironment: Physiologically Relevant Co-Culture Systems in Drug Discovery","volume":"69\u201370","author":"E. BL","year":"2014","journal-title":"Adv Drug Delivery Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s002530051546","article-title":"Pharmaceutically Active Secondary Metabolites of Microorganisms","volume":"52","author":"AL Demain","year":"1999","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1074-5521(02)00105-9","article-title":"Toward High-Throughput Synthesis of Complex Natural Product-Like Compounds in the Genomics and Proteomics Age","volume":"9","author":"P Arya","year":"2002","journal-title":"Chem Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cyto.2014.10.013","article-title":"An Anti-Inflammatory Property of Candida Albicans Beta-Glucan: Induction of High Levels of Interleukin-1 Receptor Antagonist Via a Dectin-1\/Cr3 Independent Mechanism","volume":"71","author":"SP Smeekens","year":"2015","journal-title":"Cytokine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"767061","DOI":"10.1155\/2014\/767061","article-title":"Potent Anti-Inflammatory Activity of Pyrenocine a Isolated from the Marine-Derived Fungus Penicillium Paxilli Ma(G)K","volume":"2014","author":"TR Toledo","year":"2014","journal-title":"Mediators Inflamm"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10529-012-1098-x","article-title":"Two Novel Hydroperoxylated Products of 20(S)-Protopanaxadiol Produced by Mucor Racemosus and Their Cytotoxic Activities against Human Prostate Cancer Cells","volume":"35","author":"G Chen","year":"2013","journal-title":"Biotechnol Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijbiomac.2010.05.002","article-title":"Production, Physiochemical and Antimicrobial Properties of Fungal Chitosan from Rhizomucor Miehei and Mucor Racemosus","volume":"47","author":"F Tajdini","year":"2010","journal-title":"Int J Biol Macromol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jprot.2012.07.012","article-title":"Proteome Signatures of Inflammatory Activated Primary Human Peripheral Blood Mononuclear Cells","volume":"76","author":"VJ Haudek-Prinz","year":"2012","journal-title":"J Proteomics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1021\/pr5008625","article-title":"Comprehensive Assessment of Proteins Regulated by Dexamethasone Reveals Novel Effects in Primary Human Peripheral Blood Mononuclear Cells","volume":"13","author":"A Bileck","year":"2014","journal-title":"J Proteome Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1007\/s00216-015-8817-9","article-title":"Quantification of Cytokines Secreted by Primary Human Cells Using Multiple Reaction Monitoring: Evaluation of Analytical Parameters","volume":"407","author":"B Muqaku","year":"2015","journal-title":"Anal Bioanal Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2174\/156652410790963312","article-title":"Challenges in Mass Spectrometry Based Targeted Metabolomics","volume":"10","author":"T Koal","year":"2010","journal-title":"Curr Mol Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/1615-9861(200104)1:5<699::AID-PROT699>3.0.CO;2-C","article-title":"A Comparison between Sypro Ruby and Ruthenium Ii Tris (Bathophenanthroline Disulfonate) as Fluorescent Stains for Protein Detection in Gels","volume":"1","author":"T Rabilloud","year":"2001","journal-title":"Proteomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1002\/elps.201300326","article-title":"Myofibroblasts Are Important Contributors to Human Hepatocellular Carcinoma: Evidence for Tumor Promotion by Proteome Profiling","volume":"34","author":"A Slany","year":"2013","journal-title":"Electrophoresis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1002\/elps.201300326","article-title":"Myofibroblasts Are Important Contributors to Human Hepatocellular Carcinoma: Evidence for Tumor Promotion by Proteome Profiling","volume":"34","author":"A Slany","year":"2013","journal-title":"Electrophoresis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: An Open Source Document Editor for Creating and Analyzing Targeted Proteomics Experiments","volume":"26","author":"B MacLean","year":"2010","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1074\/mcp.M200026-MCP200","article-title":"Concomitant Determination of Absolute Values of Cellular Protein Amounts, Synthesis Rates, and Turnover Rates by Quantitative Proteome Profiling","volume":"1","author":"C Gerner","year":"2002","journal-title":"Mol Cell Proteomics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00281-011-0285-5","article-title":"Endothelium\u2014Role in Regulation of Coagulation and Inflammation","volume":"34","author":"VW van Hinsbergh","year":"2012","journal-title":"Semin Immunopathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1074\/mcp.M500061-MCP200","article-title":"Exponentially Modified Protein Abundance Index (Empai) for Estimation of Absolute Protein Amount in Proteomics by the Number of Sequenced Peptides Per Protein","volume":"4","author":"Y Ishihama","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MCO.0b013e328314b9ac","article-title":"The Polyamine and Histamine Metabolic Interplay in Cancer and Chronic Inflammation","volume":"12","author":"G Garcia-Faroldi","year":"2009","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tips.2012.02.004","article-title":"Prostaglandins and Chronic Inflammation","volume":"33","author":"T Aoki","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"ref23","article-title":"Mammalian Antimicrobial Peptides: Promising Therapeutic Targets against Infection and Chronic Inflammation","author":"P Dutta","year":"2015","journal-title":"Curr Top Med Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.coph.2006.03.007","article-title":"Targeting the Stromal Microenvironment in Chronic Inflammation","volume":"6","author":"A Filer","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2119\/molmed.2009.00062","article-title":"Spermine Protects Mice against Lethal Sepsis Partly by Attenuating Surrogate Inflammatory Markers","volume":"15","author":"S Zhu","year":"2009","journal-title":"Mol Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11010-006-9280-x","article-title":"Lysophosphatidylcholine Induces Inflammatory Activation of Human Coronary Artery Smooth Muscle Cells","volume":"295","author":"N Aiyar","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"ref27","first-page":"371","article-title":"Effects of Dexamethasone on Lipid Metabolism in Rat Organs","volume":"26","author":"N Kaur","year":"1989","journal-title":"Indian J Biochem Biophys"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1253\/circj.CJ-11-1217","article-title":"Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients with Chronic Thromboembolic Pulmonary Hypertension","volume":"76","author":"K Sugimura","year":"2012","journal-title":"Circ J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0140367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T21:42:12Z","timestamp":1567287732000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0140367"}},"subtitle":[],"editor":[{"given":"Hsin-Chih","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,23]]},"references-count":28,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0140367","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,23]]}}}