{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:51:36Z","timestamp":1776232296071,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0140968","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T18:08:14Z","timestamp":1445364494000},"page":"e0140968","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability"],"prefix":"10.1371","volume":"10","author":[{"given":"Yusuke","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayori","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoka","family":"Doda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Fukuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"issue":"6067","key":"ref1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1126\/science.1209037","article-title":"The centrosome in cells and organisms","volume":"335","author":"M Bornens","year":"2012","journal-title":"Science"},{"issue":"6557","key":"ref2","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/378578a0","article-title":"Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex","volume":"378","author":"Y Zheng","year":"1995","journal-title":"Nature"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.200305048","article-title":"Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells","volume":"162","author":"Y Terada","year":"2003","journal-title":"The Journal of cell biology"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cub.2004.03.042","article-title":"Microtubule nucleation at non-spindle pole body microtubule-organizing centers requires fission yeast centrosomin-related protein mod20p","volume":"14","author":"KE Sawin","year":"2004","journal-title":"Current biology: CB"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1091\/mbc.E07-04-0371","article-title":"CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex","volume":"19","author":"KW Fong","year":"2008","journal-title":"Molecular biology of the cell"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1086\/429930","article-title":"Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings","volume":"76","author":"CG Woods","year":"2005","journal-title":"Am J Hum Genet"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(01)00364-6","article-title":"Microtubule "plus-end-tracking proteins": The end is just the beginning","volume":"105","author":"SC Schuyler","year":"2001","journal-title":"Cell"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/jb\/mvg148","article-title":""Search-and-capture" of microtubules through plus-end-binding proteins (+TIPs)","volume":"134","author":"Y Mimori-Kiyosue","year":"2003","journal-title":"Journal of biochemistry"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ceb.2003.11.010","article-title":"Cortical control of microtubule stability and polarization","volume":"16","author":"GG Gundersen","year":"2004","journal-title":"Current opinion in cell biology"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0962-8924(03)00074-6","article-title":"Surfing on microtubule ends","volume":"13","author":"P Carvalho","year":"2003","journal-title":"Trends Cell Biol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrm1664","article-title":"CLIPs and CLASPs and cellular dynamics","volume":"6","author":"N Galjart","year":"2005","journal-title":"Nature reviews Molecular cell biology"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrm2369","article-title":"Tracking the ends: a dynamic protein network controls the fate of microtubule tips","volume":"9","author":"A Akhmanova","year":"2008","journal-title":"Nature reviews Molecular cell biology"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1091\/mbc.02-04-0210","article-title":"EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules","volume":"13","author":"JS Tirnauer","year":"2002","journal-title":"Molecular biology of the cell"},{"issue":"7172","key":"ref14","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nature06386","article-title":"Reconstitution of a microtubule plus-end tracking system in vitro","volume":"450","author":"P Bieling","year":"2007","journal-title":"Nature"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1083\/jcb.200809190","article-title":"CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1\/tubulin-binding sites","volume":"183","author":"P Bieling","year":"2008","journal-title":"The Journal of cell biology"},{"issue":"16","key":"ref16","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1091\/mbc.E09-01-0009","article-title":"Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics","volume":"20","author":"KW Fong","year":"2009","journal-title":"Molecular biology of the cell"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.molcel.2006.10.016","article-title":"Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation","volume":"24","author":"YH Kang","year":"2006","journal-title":"Molecular cell"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/emboj\/17.3.667","article-title":"AIM-1: a mammalian midbody-associated protein required for cytokinesis","volume":"17","author":"Y Terada","year":"1998","journal-title":"The EMBO journal"},{"issue":"19","key":"ref19","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.cub.2012.07.047","article-title":"A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins","volume":"22","author":"K Jiang","year":"2012","journal-title":"Current biology: CB"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.200912163","article-title":"CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response","volume":"189","author":"AR Barr","year":"2010","journal-title":"The Journal of cell biology"},{"issue":"29","key":"ref21","doi-asserted-by":"crossref","first-page":"22658","DOI":"10.1074\/jbc.M110.105965","article-title":"Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex","volume":"285","author":"Z Wang","year":"2010","journal-title":"J Biol Chem"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1600-0854.2006.00400.x","article-title":"Microtubule plus end: a hub of cellular activities","volume":"7","author":"G Lansbergen","year":"2006","journal-title":"Traffic"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1073\/pnas.77.3.1561","article-title":"Taxol stabilizes microtubules in mouse fibroblast cells","volume":"77","author":"PB Schiff","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6257","key":"ref24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/343461a0","article-title":"Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons","volume":"343","author":"A Caceres","year":"1990","journal-title":"Nature"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(91)90510-6","article-title":"Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation","volume":"64","author":"JH Dinsmore","year":"1991","journal-title":"Cell"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1539","article-title":"A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size","volume":"37","author":"J Bond","year":"2005","journal-title":"Nat Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0140968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T23:14:34Z","timestamp":1540250074000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0140968"}},"subtitle":[],"editor":[{"given":"Takashi","family":"Toda","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":26,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0140968","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,20]]}}}