{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:16:25Z","timestamp":1777896985365,"version":"3.51.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0141477","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T16:32:02Z","timestamp":1446049922000},"page":"e0141477","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of PDE5 Inhibitors and sGC Stimulators in a Rat Model of Artificial Ureteral Calculosis"],"prefix":"10.1371","volume":"10","author":[{"given":"Peter","family":"Sandner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Tinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannapia","family":"Affaitati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Costantini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Adele","family":"Giamberardino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0072-9752(06)80028-X","article-title":"Chapter 24. Referred pain from internal organs","volume":"81","author":"MA Giamberardino","year":"2006","journal-title":"Handb Clin Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.pain.2010.06.023","article-title":"Viscero-visceral hyperalgesia: characterization in different clinical models","volume":"151","author":"MA Giamberardino","year":"2010","journal-title":"Pain"},{"issue":"2","key":"ref3","first-page":"101","article-title":"Epidemiology of urolithiasis: an update","volume":"5","author":"A Trinchieri","year":"2008","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mcna.2010.08.034","article-title":"Medical and medical\/urologic approaches in acute and chronic urologic stone disease","volume":"95","author":"TY Tseng","year":"2011","journal-title":"Med Clin North Am"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(94)90152-X","article-title":"Effects of extracorporeal shock-wave lithotripsy on referred hyperalgesia from renal\/ureteral calculosis","volume":"56","author":"MA Giamberardino","year":"1994","journal-title":"Pain"},{"key":"ref6","first-page":"101","article-title":"Referred pain from viscera: when the symptom persists despite the extinction of the visceral focus","volume":"20","author":"L Vecchiet","year":"1992","journal-title":"Adv Pain Res Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0304-3959(89)90087-0","article-title":"Pain from renal\/ureteral calculosis: evaluation of sensory thresholds in the lumbar area","volume":"36","author":"L Vecchiet","year":"1989","journal-title":"Pain"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e5499","DOI":"10.1136\/bmj.e5499","article-title":"Management of renal colic","volume":"345","author":"M Bultitude","year":"2012","journal-title":"BMJ"},{"issue":"10","key":"ref9","first-page":"772","article-title":"Urinary stone disease\u2014assessment and management","volume":"40","author":"F Macneil","year":"2011","journal-title":"Aust Fam Physician"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000100830","article-title":"Physiology and pharmacology of the human ureter: basis for current and future treatments","volume":"78","author":"AE Canda","year":"2007","journal-title":"Urol Int"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.annemergmed.2007.05.015","article-title":"A systematic review of medical therapy to facilitate passage of ureteral calculi","volume":"50","author":"A Singh","year":"2007","journal-title":"Ann Emerg Med"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1464-410X.2009.09014.x","article-title":"Alpha-Blockers to assist stone clearance after extracorporeal shock wave lithotripsy: a meta-analysis","volume":"106","author":"Y Zhu","year":"2010","journal-title":"BJU Int"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/jsm.12095","article-title":"Synergistic effects of BAY 60\u20134552 and vardenafil on relaxation of corpus cavernosum tissue of patients with erectile dysfunction and clinical phosphodiesterase type 5 inhibitor failure","volume":"10","author":"M Albersen","year":"2013","journal-title":"J Sex Med"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.urology.2012.11.028","article-title":"Phosphodiesterase-5 expression and function in the lower urinary tract: a critical review","volume":"81","author":"CS Lin","year":"2013","journal-title":"Urology"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.eururo.2011.05.054","article-title":"Phosphodiesterase type 5 inhibitors in the management of non-neurogenic male lower urinary tract symptoms: critical analysis of current evidence","volume":"60","author":"JI Mart\u00ednez-Salamanca","year":"2011","journal-title":"Eur Urol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1345\/aph.1R528","article-title":"Role of phosphodiesterase type 5 inhibitors for lower urinary tract symptoms","volume":"47","author":"MS Miller","year":"2013","journal-title":"Ann Pharmacother"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1210\/en.2006-1079","article-title":"Characterization and functional role of androgen-dependent PDE5 activity in the bladder","volume":"148","author":"S Filippi","year":"2007","journal-title":"Endocrinology"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1464-410X.2006.06501.x","article-title":"Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms","volume":"98","author":"H Tinel","year":"2006","journal-title":"BJU Int"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00240-006-0073-1","article-title":"In vitro effects of PDE5 inhibitors sildenafil, vardenafil and tadalafil on isolated human ureteral smooth muscle: a basic research approach","volume":"35","author":"C Gratzke","year":"2007","journal-title":"Urol Res"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF00191209","article-title":"Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro","volume":"12","author":"A Taher","year":"1994","journal-title":"World J Urol"},{"issue":"20","key":"ref21","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1161\/CIRCULATIONAHA.110.981738","article-title":"Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease","volume":"123","author":"JP Stasch","year":"2011","journal-title":"Circulation"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0304-3959(94)00208-V","article-title":"Artificial ureteral calculosis in rats: behavioural characterization of visceral pain episodes and their relationship with referred lumbar muscle hyperalgesia","volume":"61","author":"MA Giamberardino","year":"1995","journal-title":"Pain"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/GCO.0000000000000083","article-title":"Pain thresholds in women with chronic pelvic pain","volume":"26","author":"MA Giamberardino","year":"2014","journal-title":"Curr Opin Obstet Gynecol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1472-8206.2002.00068.x","article-title":"Effects of tramadol on behavioural indicators of colic pain in a rat model of ureteral calculosis","volume":"16","author":"G Affaitati","year":"2002","journal-title":"Fundam Clin Pharmacol"},{"issue":"1\u20132","key":"ref25","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0006-8993(00)02728-1","article-title":"Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period","volume":"878","author":"MA Giamberardino","year":"2000","journal-title":"Brain Res"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-2999(95)00104-S","article-title":"Effects of spasmolytic and\/or non-steroidal antiinflammatory drugs on muscle hyperalgesia of ureteral origin in rats","volume":"278","author":"MA Giamberardino","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"ref27","article-title":"Ultramicronized palmitoylethanolamide reduces viscero-visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells","author":"T Iuvone","year":"2015","journal-title":"Pain"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s000110050349","article-title":"Antinociceptive activity of metamizol in rats with experimental ureteric calculosis: central and peripheral components","volume":"47","author":"JM Laird","year":"1998","journal-title":"Inflamm Res"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/fcp.12038","article-title":"Effects of tramadol on viscero-visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis","volume":"28","author":"M Lopopolo","year":"2014","journal-title":"Fundam Clin Pharmacol"},{"issue":"5 Pt 2","key":"ref30","first-page":"R1409","article-title":"Effects of artificial calculosis on rat ureter motility: peripheral contribution to the pain of ureteric colic","volume":"272","author":"JM Laird","year":"1997","journal-title":"Am J Physiol"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1464-410X.2006.06501.x","article-title":"Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms","volume":"98","author":"H Tinel","year":"2006","journal-title":"BJU Int"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"MJ Mulvany","year":"1977","journal-title":"Circ Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yhbeh.2010.09.008","article-title":"Sex differences in the analgesic effects of ICI 182,780 and Flutamide on ureteral calculosis in rats","volume":"59","author":"G Affaitati","year":"2011","journal-title":"Horm Behav"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ejpain.2009.10.016","article-title":"Estradiol and testosterone differently affect visceral pain-related behavioural responses in male and female rats","volume":"14","author":"AM Aloisi","year":"2010","journal-title":"Eur J Pain"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: The ARRIVE guidelines","volume":"160","author":"C Kilkenny","year":"2010","journal-title":"BJP"},{"key":"ref36","first-page":"11","article-title":"Comparisons of different animal models of chronic pain","volume":"13","author":"D Albe-Fessard","year":"1990","journal-title":"Adv Pain Res Ther"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1748-1716.1993.tb09578.x","article-title":"Immunohistochemical localization of peripheral nitric oxide synthase-containing nerves using antibodies raised against synthesized C- and N-terminal fragments of a cloned enzyme from rat brain","volume":"148","author":"P Alm","year":"1993","journal-title":"Acta Physiol Scand"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0090-4295(94)80206-8","article-title":"Localization of nitric oxide synthase activity in the human lower urinary tract and its correlation with neuroeffector responses","volume":"44","author":"I Ehr\u00e9n","year":"1994","journal-title":"Urology"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"256.e1","DOI":"10.1016\/j.urology.2013.09.005","article-title":"BAY 41\u20132272, a Soluble Guanylate Cyclase Stimulator, Relaxes Isolated Human Ureter in a Standardized In Vitro Model","volume":"83","author":"R Miyaoka","year":"2014","journal-title":"Urology"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1451.e13","DOI":"10.1016\/j.urology.2013.08.023","article-title":"Pharmacologic characterization of human male urethral smooth muscle: an in vitro approach","volume":"82","author":"GT Kedia","year":"2013","journal-title":"Urology"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1089\/end.2012.0612","article-title":"Direct effects of vardenafil on the ureter: in vitro investigation and potential clinical applications of intralumenal administration","volume":"27","author":"E Liatsikos","year":"2013","journal-title":"J Endourol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0141477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T22:26:04Z","timestamp":1567290364000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0141477"}},"subtitle":[],"editor":[{"given":"Harald HHW","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,28]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0141477","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,28]]}}}