{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:52:56Z","timestamp":1792641176297,"version":"4.5.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0141823","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T18:46:28Z","timestamp":1447872388000},"page":"e0141823","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mechanical Stimulation by Postnasal Drip Evokes Cough"],"prefix":"10.1371","volume":"10","author":[{"given":"Toshiyuki","family":"Iwata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Marumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nakaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kanemitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo","family":"Kamei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutoshi","family":"Setou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thorax.58.4.339","article-title":"Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)","volume":"58","author":"SS Birring","year":"2003","journal-title":"Thorax"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1378\/chest.127.6.1991","article-title":"A comparison of gender differences in health-related quality of life in acute and chronic coughers","volume":"127","author":"CT French","year":"2005","journal-title":"Chest"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1183\/09031936.00101006","article-title":"ERS guidelines on the assessment of cough","volume":"29","author":"AH Morice","year":"2007","journal-title":"Eur Respir J"},{"issue":"Suppl 1","key":"ref4","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2006.065144","article-title":"Recommendations for the management of cough in adults","volume":"61","author":"AH Morice","year":"2006","journal-title":"Thorax"},{"issue":"7333","key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/bmj.324.7333.329","article-title":"Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults","volume":"324","author":"K Schroeder","year":"2002","journal-title":"BMJ"},{"issue":"1 Suppl","key":"ref6","doi-asserted-by":"crossref","first-page":"63S","DOI":"10.1378\/chest.129.1_suppl.63S","article-title":"Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome): ACCP evidence-based clinical practice guidelines","volume":"129","author":"MR Pratter","year":"2006","journal-title":"Chest"},{"issue":"23","key":"ref7","doi-asserted-by":"crossref","first-page":"10490","DOI":"10.1073\/pnas.1002128107","article-title":"Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry","volume":"107","author":"K Ikegami","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"ref8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cell.2011.10.052","article-title":"Coordinated Ciliary Beating Requires Odf2-Mediated Polarization of Basal Bodies via Basal Feet","volume":"148","author":"K Kunimoto","year":"2012","journal-title":"Cell"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1152\/ajplegacy.1975.229.3.770","article-title":"Neural mechanisms of sneeze","volume":"229","author":"HL Batsel","year":"1975","journal-title":"Am J Physiol"},{"key":"ref10","unstructured":"Korp\u00e1\u00e9s J, Tomori Z. Cough and other respiratory reflexes: S. Karger (Basel and New York); 1979."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1745-9974-3-10","article-title":"Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig","volume":"3","author":"SY Leung","year":"2007","journal-title":"Cough"},{"issue":"1\u20133","key":"ref12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ejphar.2007.03.036","article-title":"Role of cyclin-dependent kinase 5 in capsaicin-induced cough","volume":"566","author":"J Kamei","year":"2007","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.33549\/physiolres.930840","article-title":"Early and late allergic phase related cough response in sensitized guinea pigs with experimental allergic rhinitis","volume":"55","author":"M Brozmanova","year":"2006","journal-title":"Physiol Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1465-9921-10-61","article-title":"Does unrestrained single-chamber plethysmography provide a valid assessment of airway responsiveness in allergic BALB\/c mice?","volume":"10","author":"Q Zhang","year":"2009","journal-title":"Respir Res"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jaci.2005.08.020","article-title":"Physiologic assessment of allergic rhinitis in mice: role of the high-affinity IgE receptor (FcepsilonRI)","volume":"116","author":"S Miyahara","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1165\/rcmb.2008-0487OC","article-title":"Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases","volume":"42","author":"JA Vanoirbeek","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"GK Reddy","year":"1996","journal-title":"Clin Biochem"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1183\/09031936.06.00096905","article-title":"Cough: what's in a name?","volume":"28","author":"J Widdicombe","year":"2006","journal-title":"Eur Respir J"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm0796-814","article-title":"Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough","volume":"2","author":"AJ Fox","year":"1996","journal-title":"Nat Med"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/01.PHM.0000064731.36291.61","article-title":"Videofluoroscopy of the diaphragm during voluntary and reflex cough in humans","volume":"82","author":"RE Stephens","year":"2003","journal-title":"Am J Phys Med Rehabil"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1164\/ajrccm.150.2.8049818","article-title":"Capsaicin cough sensitivity decreases with successful treatment of chronic cough","volume":"150","author":"F O'Connell","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1378\/chest.85.3.346","article-title":"Postnasal Drip Causes Cough and Is Associated with Reversible Upper Airway-Obstruction","volume":"85","author":"RS Irwin","year":"1984","journal-title":"Chest"},{"issue":"9229","key":"ref23","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0140-6736(00)02584-8","article-title":"Airway remodelling in cough-variant asthma","volume":"356","author":"A Niimi","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaci.2005.07.010","article-title":"Nature of airway inflammation and remodeling in chronic cough","volume":"116","author":"A Niimi","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"21","key":"ref25","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1056\/NEJMoa1014350","article-title":"Effect of bronchoconstriction on airway remodeling in asthma","volume":"364","author":"CL Grainge","year":"2011","journal-title":"N Engl J Med"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1164\/ajrccm.156.3.9606031","article-title":"Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography","volume":"156","author":"E Hamelmann","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/labinvest.3700452","article-title":"Noninvasive system for evaluating allergen-induced nasal hypersensitivity in murine allergic rhinitis","volume":"86","author":"M Nakaya","year":"2006","journal-title":"Lab Invest"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1183\/09031936.98.11051064","article-title":"Eosinophilic inflammation in cough variant asthma","volume":"11","author":"A Niimi","year":"1998","journal-title":"Eur Respir J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-9974-4-1","article-title":"Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats","volume":"4","author":"I Poliacek","year":"2008","journal-title":"Cough"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/2047-783X-15-S2-184","article-title":"Central Antitussive Effect of Codeine in the Anesthetized Rabbit","volume":"15","author":"M Simera","year":"2010","journal-title":"Eur J Med Res"},{"issue":"17","key":"ref31","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1001\/archinte.1997.00440380091009","article-title":"Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma","volume":"157","author":"RS Irwin","year":"1997","journal-title":"Arch Intern Med"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1152\/jappl.1980.48.3.511","article-title":"Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs","volume":"48","author":"MP Kaufman","year":"1980","journal-title":"J Appl Physiol"},{"issue":"187","key":"ref33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-540-79842-2_6","article-title":"Cough sensors. V. Pharmacological modulation of cough sensors","author":"SB Mazzone","year":"2009","journal-title":"Handb Exp Pharmacol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.1954.sp005033","article-title":"Respiratory reflexes from the trachea and bronchi of the cat","volume":"123","author":"JG Widdicombe","year":"1954","journal-title":"J Physiol"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1113\/jphysiol.1954.sp005034","article-title":"Receptors in the trachea and bronchi of the cat","volume":"123","author":"JG Widdicombe","year":"1954","journal-title":"J Physiol"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1164\/rccm.200905-0665OC","article-title":"TRPA1 agonists evoke coughing in guinea pig and human volunteers","volume":"180","author":"MA Birrell","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"1\u20132","key":"ref37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0034-5687(00)00203-6","article-title":"Reflexes from airway rapidly adapting receptors","volume":"125","author":"G Sant'Ambrogio","year":"2001","journal-title":"Respir Physiol"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ar.a.10003","article-title":"Functional morphology and physiology of pulmonary rapidly adapting receptors (RARs)","volume":"270","author":"J Widdicombe","year":"2003","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/phrs.1996.0122","article-title":"Actions of moguisteine on cough and pulmonary rapidly adapting receptor activity in the guinea pig","volume":"35","author":"T Morikawa","year":"1997","journal-title":"Pharmacol Res"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs","volume":"79","author":"UG Lalloo","year":"1995","journal-title":"J Appl Physiol"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.resp.2005.11.010","article-title":"Current and future peripherally-acting antitussives","volume":"152","author":"PV Dicpinigaitis","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0003-4975(94)90378-6","article-title":"Postoperative bronchopleural fistula: endoscopic closure in 12 patients","volume":"57","author":"E Scappaticci","year":"1994","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0168-0102(98)00075-3","article-title":"Upper airway motor outputs during sneezing and coughing in decerebrate cats","volume":"32","author":"I Satoh","year":"1998","journal-title":"Neurosci Res"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"e59263","DOI":"10.1371\/journal.pone.0059263","article-title":"Detection of mouse cough based on sound monitoring and respiratory airflow waveforms","volume":"8","author":"L Chen","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pupt.2004.09.005","article-title":"Post-nasal drip syndrome\u2014a symptom to be sniffed at?","volume":"17","author":"AH Morice","year":"2004","journal-title":"Pulm Pharmacol Ther"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"L833","DOI":"10.1152\/ajplung.00173.2001","article-title":"Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia","volume":"282","author":"DS Southam","year":"2002","journal-title":"Am J Physiol-Lung C"},{"issue":"Pt 1","key":"ref47","first-page":"71","article-title":"The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study","volume":"132","author":"RJ Pack","year":"1981","journal-title":"J Anat"},{"issue":"Suppl 4","key":"ref48","first-page":"171","article-title":"Cough sensitivity in allergic rhinitis","volume":"56","author":"R Pecova","year":"2005","journal-title":"J Physiol Pharmacol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pupt.2005.04.004","article-title":"The effects of nasal histamine challenge on cough reflex in healthy volunteers","volume":"19","author":"J Plevkova","year":"2006","journal-title":"Pulm Pharmacol Ther"},{"issue":"Pt 2","key":"ref50","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2003.057885","article-title":"Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs","volume":"557","author":"BJ Canning","year":"2004","journal-title":"J Physiol"},{"issue":"11","key":"ref51","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1073\/pnas.111133298","article-title":"Mechanical stress is communicated between different cell types to elicit matrix remodeling","volume":"98","author":"MA Swartz","year":"2001","journal-title":"P Natl Acad Sci USA"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1165\/rcmb.2002-0121OC","article-title":"Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium","volume":"28","author":"DJ Tschumperlin","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1164\/rccm.200303-365OC","article-title":"Primary ciliary dyskinesia: diagnostic and phenotypic features","volume":"169","author":"PG Noone","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1152\/jappl.1990.69.5.1670","article-title":"Cough-enhanced mucus clearance in the normal lung","volume":"69","author":"WD Bennett","year":"1990","journal-title":"J Appl Physiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0141823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T14:42:22Z","timestamp":1653576142000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0141823"}},"subtitle":[],"editor":[{"given":"Yuanpu Peter","family":"Di","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,18]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0141823","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,18]]}}}