{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:25:39Z","timestamp":1767839139919,"version":"3.49.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0142158","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T19:12:23Z","timestamp":1446837143000},"page":"e0142158","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fetal Sex Modulates Developmental Response to Maternal Malnutrition"],"prefix":"10.1371","volume":"10","author":[{"given":"Antonio","family":"Gonzalez-Bulnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Torres-Rovira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Astiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ovilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Sanchez-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Gomez-Fidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariluz","family":"Perez-Solana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Martin-Lluch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Garcia-Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Vazquez-Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/485S2a","article-title":"Diabetes in numbers","volume":"485","author":"T Scully","year":"2012","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.1095292","article-title":"Living with the past: evolution, development, and patterns of disease","volume":"305","author":"PD Gluckman","year":"2004","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1038\/485S14a","article-title":"Public health: India&apos;s diabetes time bomb","volume":"485","author":"P Shetty","year":"2012","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrendo.2013.102","article-title":"Diabetes and its comorbidities\u2014where East meets West","volume":"9","author":"AP Kong","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"ref5","first-page":"43","article-title":"Intrauterine growth curves in north Indian babies: weight, length, head circumference and ponderal index","volume":"27","author":"M Mohan","year":"1990","journal-title":"Indian Pediatr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.2337\/diabetes.48.12.2422","article-title":"Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both?","volume":"48","author":"A Bavdekar","year":"1999","journal-title":"Diabetes"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/cen.12143","article-title":"Size at birth, morning cortisol and cardiometabolic risk markers in healthy Indian children","volume":"80","author":"GV Krishnaveni","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-11-0489","article-title":"Sex differences in developmental programming models","volume":"145","author":"CE Aiken","year":"2013","journal-title":"Reproduction"},{"key":"ref9","first-page":"226","article-title":"Of pigs and men and research: a review of applications and analogies of the pig, Sus scrofa, in human medical research","volume":"3","author":"WR Douglas","year":"1972","journal-title":"Space Life Sci"},{"key":"ref10","first-page":"307","article-title":"The pig as a model for the study of obesity and of control of food intake: a review","volume":"52","author":"KA Houpt","year":"1979","journal-title":"Yale J Biol Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7150\/ijbs.3.179","article-title":"Advances in swine biomedical model genomics","volume":"3","author":"JK Lunney","year":"2007","journal-title":"Intern J Biol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jn\/138.2.397","article-title":"The development of porcine models of obesity and the metabolic syndrome","volume":"138","author":"ME Spurlock","year":"2008","journal-title":"J Nutr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1017\/S0954422410000077","article-title":"Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?","volume":"23","author":"P Guilloteau","year":"2010","journal-title":"Nutr Res Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1439-0531.2012.02056.x","article-title":"Domestic animal models for biomedical research","volume":"47","author":"A Bahr","year":"2012","journal-title":"Reprod Domest Anim"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11248-013-9755-y","article-title":"Genetically engineered pig models for diabetes research","volume":"23","author":"E Wolf","year":"2014","journal-title":"Transgenic Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4939-1594-1_4","article-title":"Nuclear transfer and transgenesis in the pig","volume":"1222","author":"M Kurome","year":"2015","journal-title":"Methods Mol Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.placenta.2015.01.196","article-title":"IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction","volume":"36","author":"S Barbaux","year":"2015","journal-title":"Placenta"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0301-6226(02)00181-1","article-title":"Variation of piglets\u2019 birth weight and consequences on subsequent performance","volume":"78","author":"N Quiniou","year":"2002","journal-title":"Livestock Prod Sci"},{"key":"ref19","first-page":"128","article-title":"Heavy newborn piglets develop a high carcass quality","volume":"82","author":"G Kuhn","year":"2002","journal-title":"Fleischwirtschaft"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"826","DOI":"10.2527\/2004.823826x","article-title":"Effect of early gestation feeding, birth weight, and gender of progeny on muscle fiber characteristics of pigs at slaughter","volume":"82","author":"G Bee","year":"2004","journal-title":"J Anim Sci"},{"issue":"Suppl","key":"ref21","doi-asserted-by":"crossref","first-page":"E113","DOI":"10.2527\/2006.8413_supplE113x","article-title":"Consequences of birth weight for postnatal growth performance and carcass quality in pigs as related to myogenesis","volume":"84","author":"C Rehfeldt","year":"2006","journal-title":"J Anim Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1530\/REP-12-0105","article-title":"Gender-specific early postnatal catch-up growth after intrauterine growth retardation by food restriction in swine with obesity\/leptin resistance","volume":"144","author":"A Gonzalez-Bulnes","year":"2012","journal-title":"Reproduction"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e78424","DOI":"10.1371\/journal.pone.0078424","article-title":"Maternal malnutrition and offspring sex determine juvenile obesity and metabolic disorders in a swine model of leptin resistance","volume":"8","author":"A Barbero","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e66728","DOI":"10.1371\/journal.pone.0066728","article-title":"Sex and breed-dependent organ development and metabolic responses in foetuses from lean and obese\/leptin resistant swine","volume":"8","author":"L Torres-Rovira","year":"2013","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1017\/S0007114513002948","article-title":"Prenatal programming in an obese swine model: sex-related effects of maternal energy restriction on morphology, metabolism and hypothalamic gene expression","volume":"111","author":"C Ovilo","year":"2014","journal-title":"Br J Nutr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"510149","DOI":"10.1100\/2012\/510149","article-title":"Diet-induced swine model with obesity\/leptin resistance for the study of metabolic syndrome and type 2 diabetes","volume":"2012","author":"L Torres-Rovira","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1871530311313020002","article-title":"Effect of an obesogenic diet during the juvenile period on growth pattern, fatness and metabolic, cardiovascular and reproductive features of swine with obesity\/leptin resistance","volume":"13","author":"L Torres-Rovira","year":"2013","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S0016672305007330","article-title":"Fine mapping of porcine chromosome 6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross","volume":"85","author":"C Ovilo","year":"2005","journal-title":"Genet Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000209972","article-title":"Obesity in emerging nations: evolutionary origins and the impact of a rapid nutrition transition","volume":"63","author":"AM Prentice","year":"2009","journal-title":"Nestle Nutr Workshop Ser Pediatr Program"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/ije\/dyn183","article-title":"Ethnic variability in adiposity and cardiovascular risk: the variable disease selection hypothesis","volume":"38","author":"JC Wells","year":"2009","journal-title":"Int J Epidemiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.4103\/2230-8210.104024","article-title":"Beyond the Barker hypothesis and the thrifty genotype\u2014The womb, ethnicity, genes and the environment\u2014Recent perspectives on the evolution of diabetes and the metabolic syndrome in India","volume":"16","author":"N Thomas","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000354957","article-title":"Nutrition and chronic disease: lessons from the developing and developed world","volume":"78","author":"AM Prentice","year":"2014","journal-title":"Nestle Nutr Inst Workshop Ser"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/iub.1396","article-title":"Type-2 diabetes: Current understanding and future perspectives","volume":"67","author":"A Pandey","year":"2015","journal-title":"IUBMB Life"},{"key":"ref34","article-title":"Nutrient requirement standards for pigs","year":"2003"},{"key":"ref35","first-page":"403","article-title":"Application of the orbital sinus bleeding technique to swine","volume":"19","author":"RG Huhn","year":"1969","journal-title":"Lab Anim Care"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ygcen.2011.12.038","article-title":"Reproductive, endocrine and metabolic feto-maternal features and placental gene expression in a swine breed with obesity\/leptin resistance","volume":"176","author":"A Gonzalez-Bulnes","year":"2012","journal-title":"Gen Comp Endocrinol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1113\/jphysiol.2006.104968","article-title":"Placental adaptive responses and fetal programming","volume":"572","author":"L Myatt","year":"2006","journal-title":"J Physiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1210\/endo.142.5.8139","article-title":"Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat","volume":"142","author":"J Lesage","year":"2001","journal-title":"Endocrinology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1113\/jphysiol.2009.184168","article-title":"Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability","volume":"588","author":"MJ Nijland","year":"2010","journal-title":"J Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1095\/biolreprod29.5.1077","article-title":"Changes in the concentrations of corticosteroids in the blood of fetal pigs and their dams during late gestation and labor","volume":"29","author":"GC Randall","year":"1983","journal-title":"Biol Reprod"},{"key":"ref41","first-page":"11","article-title":"The fetal circulation and its response to stress","volume":"6","author":"AM Rudolph","year":"1984","journal-title":"J Dev Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.2527\/jas.2006-156","article-title":"Board-invited review: intrauterine growth retardation: implications for the animal sciences","volume":"84","author":"G Wu","year":"2006","journal-title":"J Anim Sci"},{"key":"ref43","first-page":"113","article-title":"Animal models for small for gestational age and fetal programming of adult disease","volume":"68","author":"PM Vuguin","year":"2007","journal-title":"Horm Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e31390","DOI":"10.1371\/journal.pone.0031390","article-title":"Intrauterine growth retarded progeny of pregnant sows fed high protein:low carbohydrate diet is related to metabolic energy deficit","volume":"7","author":"CC Metges","year":"2012","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1016557824657","article-title":"Childhood experience and the expression of genetic potential: What childhood neglect tells us about nature and nurture?","volume":"3","author":"BD Perry","year":"2002","journal-title":"Brain Mind"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0007114500001318","article-title":"Moderate maternal vitamin A deficiency affects perinatal organ growth and development in rats","volume":"84","author":"C Antipatis","year":"2000","journal-title":"Br J Nutr"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/01.RES.0000152391.45273.A2","article-title":"Fetal liver-sparing cardiovascular adaptations linked to mother&apos;s slimness and diet","volume":"96","author":"G Haugen","year":"2005","journal-title":"Circ Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/oxfordjournals.bmb.a069888","article-title":"Glycogen reserves and their changes at birth and in anoxia","volume":"17","author":"HJ Shelley","year":"1961","journal-title":"Br Med Bull"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/oxfordjournals.bmb.a070432","article-title":"Biochemical aspects of developing function in newborn mammalian liver","volume":"22","author":"MJ Dawkins","year":"1966","journal-title":"Br Med Bull"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.2042-3306.1997.tb05077.x","article-title":"Systemic and luminal influences on the perinatal development of the gut","author":"JF Trahair","year":"1997","journal-title":"Equine Vet J Suppl"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3945\/jn.109.116822","article-title":"Intrauterine growth restriction modifies the developmental pattern of intestinal structure, transcriptomic profile, and bacterial colonization in neonatal pigs","volume":"140","author":"R D'Inca","year":"2010","journal-title":"J Nutr"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrneph.2011.1","article-title":"Prenatal programming-effects on blood pressure and renal function","volume":"7","author":"E Ritz","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod.113.111823","article-title":"How the kidney is impacted by the perinatal maternal environment to develop hypertension","volume":"89","author":"AD Paixao","year":"2013","journal-title":"Biol Reprod"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"R1010","DOI":"10.1152\/ajpregu.2000.279.3.R1010","article-title":"Effect of severe normocapnic hypoxia on renal function in growth-restricted newborn piglets","volume":"279","author":"R Bauer","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1651-2227.2004.tb00855.x","article-title":"Foetal growth of kidneys, liver and spleen in intrauterine growth restriction: &quot;programming&quot; causing &quot;metabolic syndrome&quot; in adult age","volume":"93","author":"G Latini","year":"2004","journal-title":"Acta Paediatr"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/oxfordjournals.bmb.a071239","article-title":"Control of carbohydrate metabolism in the fetus and newborn","volume":"31","author":"HJ Shelley","year":"1975","journal-title":"Br Med Bull"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00041433-200106000-00010","article-title":"The origins and roles of cholesterol and fatty acids in the fetus","volume":"12","author":"LA Woollett","year":"2001","journal-title":"Curr Opin Lipidol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/CIRCRESAHA.109.194191","article-title":"Maternal-fetal cholesterol transport in the placenta: good, bad, and target for modulation","volume":"104","author":"W Palinski","year":"2009","journal-title":"Circ Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.2527\/1997.7582197x","article-title":"Relationships of light and heavy fetuses to uterine position, placental weight, gestational age, and fetal cholesterol concentrations","volume":"75","author":"T Wise","year":"1997","journal-title":"J Anim Sci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.2527\/1993.71102732x","article-title":"Reproductive, endocrine, and organ weight differences of swine selected for high or low serum cholesterol","volume":"71","author":"T Wise","year":"1993","journal-title":"J Anim Sci"},{"key":"ref61","first-page":"1","article-title":"The amniotic fluid compartment: the fetal habitat","volume":"127","author":"W Schmidt","year":"1992","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"R2008","DOI":"10.1152\/ajpregu.00737.2007","article-title":"Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet","volume":"294","author":"R Rexhepaj","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0142158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T08:51:27Z","timestamp":1718182287000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0142158"}},"subtitle":[],"editor":[{"given":"Colette","family":"Kanellopoulos-Langevin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,6]]},"references-count":62,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0142158","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,6]]}}}