{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:01:27Z","timestamp":1783663287943,"version":"3.55.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:00:00Z","timestamp":1447200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0142750","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T18:55:14Z","timestamp":1447268114000},"page":"e0142750","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["PCR-Based Simple Subgrouping Is Validated for Classification of Gliomas and Defines Negative Prognostic Copy Number Aberrations in IDH Mutant Gliomas"],"prefix":"10.1371","volume":"10","author":[{"given":"Shunsuke","family":"Nakae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeko","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Kumon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Nagahisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Inamasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1227\/NEU.0b013e318212bcd8","article-title":"Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile","volume":"69","author":"Y Hirose","year":"2011","journal-title":"Neurosurgery"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1126\/science.1164382","article-title":"An integrated genomic analysis of human glioblastoma multiforme","volume":"321","author":"DW Parsons","year":"2008","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJMoa0808710","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"360","author":"H Yan","year":"2009","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1158\/1078-0432.CCR-13-0017","article-title":"Long-term survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations","volume":"19","author":"C Hartmann","year":"2013","journal-title":"Clin Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10014-013-0148-y","article-title":"Subgrouping of gliomas on the basis of genetic profiles","volume":"30","author":"Y Hirose","year":"2013","journal-title":"Brain Tumor Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.18632\/oncotarget.1765","article-title":"Mutation in <italic>IDH1<\/italic>, <italic>IDH2<\/italic>, and in the <italic>TERT<\/italic> promoter define clinically distinct subgroups of adult malignant gliomas","volume":"5","author":"PJ Killela","year":"2014","journal-title":"Oncotarget"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.1158\/1078-0432.CCR-14-0831","article-title":"The evolving role of molecular markers in the diagnosis and management of diffuse glioma","volume":"20","author":"JT Huse","year":"2014","journal-title":"Clin Cancer Res"},{"key":"ref8","first-page":"196","article-title":"Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, <italic>TP53<\/italic>, <italic>EGFR<\/italic>, <italic>CDK4<\/italic>, and <italic>CDKN2A<\/italic> in 91 astrocytic and oligodendroglial tumors","volume":"8","author":"K Ueki","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/sj.onc.1202298","article-title":"Evolutionary conservation and somatic mutation hotspot maps of <italic>p53<\/italic>: correlation with p53 protein structural and functional features","volume":"19","author":"DR Walker","year":"1999","journal-title":"Oncogene"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1158\/0008-5472.CAN-08-3426","article-title":"High incidence of protein-truncating <italic>TP53<\/italic> mutations in BRCA1-related breast cancer","volume":"69","author":"H Holstege","year":"2009","journal-title":"Cancer Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/humu.22552","article-title":"TP53 mutations in human cancer: Database reassessment and prospects for the next decade","volume":"35","author":"B Leroy","year":"2014","journal-title":"Hum Mutat"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0055103","article-title":"Only missense mutations affecting the DNA binding domain of P53 influence outcomes in patients with breast carcinoma","volume":"8","author":"F Vegran","year":"2013","journal-title":"PLOS one"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2353\/ajpath.2009.080958","article-title":"IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas","volume":"174","author":"T Watanebe","year":"2009","journal-title":"Am. J. Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/jjco\/hyn129","article-title":"Detection of the DNA point mutation of colorectal cancer cells isolated from feces stored under different conditions","volume":"39","author":"Y Koga","year":"2009","journal-title":"Jpn J Clin Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11060-010-0335-1","article-title":"Rosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases","volume":"102","author":"OE Solis","year":"2011","journal-title":"J Neuro Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/neuonc\/not227","article-title":"Clinical value of chromosome arms 19q and 11p losses in low grade gliomas","volume":"16","author":"A Alentorn","year":"2014","journal-title":"Neuro Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/jnci\/90.19.1473","article-title":"Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas","volume":"90","author":"JG Cairncross","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/cncr.21362","article-title":"Survival analysis of presumptive prognostic markers among oligodendrogliomas","volume":"104","author":"RE McLendon","year":"2005","journal-title":"Cancer"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.18632\/oncotarget.588","article-title":"Frequent <italic>ATRX<\/italic>, <italic>CIC<\/italic>, <italic>FUBP1<\/italic> and <italic>IDH1<\/italic> mutations refine the classification of malignant gliomas","volume":"3","author":"Y Jiao","year":"2012","journal-title":"Oncotarget"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/path.2995","article-title":"Concurrent CIC mutations, IDH mutations, and 1p\/19q loss distinguish oligodendrogliomas from other cancers","volume":"226","author":"S Yip","year":"2012","journal-title":"J pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/gcc.20108","article-title":"Chromosomal imbalances detected by array comparative genomic hybridization in human oligodendrogliomas and mixed oligoastrocytomas","volume":"42","author":"G Kitange","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/ijc.22574","article-title":"Identification of genomic aberrations associated with shorter overall survival in patients with oligodendroglial tumors","volume":"120","author":"D Trost","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1186\/s13059-014-0471-6","article-title":"Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas","volume":"15","author":"HF van Thuijl","year":"2014","journal-title":"Genome Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1158\/0008-5472.CAN-11-4134","article-title":"The human <italic>TLR<\/italic> innate immune gene family is differentially influenced by DNA stress and <italic>p53<\/italic> status in cancer cells","volume":"72","author":"M Shatz","year":"2012","journal-title":"Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/ncb2978","article-title":"A centrosomal route for cancer genome instability","volume":"16","author":"G de Carcer","year":"2014","journal-title":"Nat. Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ncb2952","article-title":"Cyclin B2 and p53 control proper timing of centrosome separation","volume":"16","author":"HJ Nam","year":"2014","journal-title":"Nat. Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0142750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T12:56:57Z","timestamp":1567342617000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0142750"}},"subtitle":[],"editor":[{"given":"Marta M.","family":"Alonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,11]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0142750","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,11]]}}}