{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:23:20Z","timestamp":1789655000902,"version":"4.0.1"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T00:00:00Z","timestamp":1447286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0142815","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T20:09:04Z","timestamp":1447358944000},"page":"e0142815","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion"],"prefix":"10.1371","volume":"10","author":[{"given":"Hongwei","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano L.","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Capobianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e4992","DOI":"10.1371\/journal.pone.0004992","article-title":"Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression","volume":"4","author":"EL Spaeth","year":"2009","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1158\/0008-5472.CAN-08-0943","article-title":"Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells","volume":"68","author":"PJ Mishra","year":"2008","journal-title":"Cancer Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.4161\/cc.5.15.3112","article-title":"Stromal fibroblasts in cancer: a novel tumor-promoting cell type","volume":"5","author":"A Orimo","year":"2006","journal-title":"Cell Cycle"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.cell.2012.11.024","article-title":"Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration","volume":"151","author":"V Luga","year":"2012","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"21677","DOI":"10.1073\/pnas.1016234107","article-title":"Malignant cells facilitate lung metastasis by bringing their own soil","volume":"107","author":"DG Duda","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2013.07.036","article-title":"Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma","volume":"154","author":"XH Zhang","year":"2013","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1195300","article-title":"Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha","volume":"330","author":"M Kraman","year":"2010","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nature11183","article-title":"Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion","volume":"487","author":"R Straussman","year":"2012","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e38811","DOI":"10.1371\/journal.pone.0038811","article-title":"Inhibition of fibroblast growth by Notch1 signaling is mediated by induction of Wnt11-dependent WISP-1","volume":"7","author":"ZJ Liu","year":"2012","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1038\/onc.2008.216","article-title":"Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7","volume":"27","author":"Y Ishikawa","year":"2008","journal-title":"Oncogene"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1038\/onc.2011.142","article-title":"Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1","volume":"30","author":"H Shao","year":"2011","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","article-title":"Deficient T cell fate specification in mice with an induced inactivation of Notch1","volume":"10","author":"F Radtke","year":"1999","journal-title":"Immunity"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1172\/JCI25001","article-title":"Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression","volume":"115","author":"K Balint","year":"2005","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1083\/jcb.130.2.393","article-title":"Identification and characterization of a fibroblast marker: FSP1","volume":"130","author":"F Strutz","year":"1995","journal-title":"J Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bbrc.2011.02.142","article-title":"Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFbeta type II receptor independent manner","volume":"407","author":"Y Teng","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1090922","article-title":"TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia","volume":"303","author":"NA Bhowmick","year":"2004","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1359\/jbmr.090412","article-title":"PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis","volume":"24","author":"R Tsutsumi","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/nature08486","article-title":"Pten in stromal fibroblasts suppresses mammary epithelial tumours","volume":"461","author":"AJ Trimboli","year":"2009","journal-title":"Nature"},{"key":"ref19","first-page":"205","article-title":"Xenograft models in immunodeficient animals: I. Nude mice: spontaneous and experimental metastasis models","volume":"58","author":"JE Price","year":"2001","journal-title":"Methods Mol Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/cncr.25652","article-title":"Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method","volume":"117","author":"SN Pinchot","year":"2011","journal-title":"Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrc1186","article-title":"The role of Notch in tumorigenesis: oncogene or tumour suppressor?","volume":"3","author":"F Radtke","year":"2003","journal-title":"Nat Rev Cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0142815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T01:40:14Z","timestamp":1540518014000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0142815"}},"subtitle":[],"editor":[{"given":"Claudia Daniela","family":"Andl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,12]]},"references-count":21,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0142815","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,12]]}}}