{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:42:18Z","timestamp":1791286938163,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0142979","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T16:45:54Z","timestamp":1448383554000},"page":"e0142979","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":119,"title":["IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production"],"prefix":"10.1371","volume":"10","author":[{"given":"Yinpu","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunliang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linrong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"PJ Murray","year":"2011","journal-title":"Nature reviews Immunology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"S Gordon","year":"2003","journal-title":"Nature reviews Immunology"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"CD Mills","year":"2000","journal-title":"Journal of immunology"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"DM Mosser","year":"2008","journal-title":"Nature reviews Immunology"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.4049\/jimmunol.181.6.3733","article-title":"Macrophage polarization in bacterial infections","volume":"181","author":"M Benoit","year":"2008","journal-title":"Journal of immunology"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"A Mantovani","year":"2004","journal-title":"Trends in immunology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.it.2012.11.001","article-title":"Epigenetic regulation of macrophage polarization and function","volume":"34","author":"LB Ivashkiv","year":"2013","journal-title":"Trends in immunology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2741\/2692","article-title":"Macrophage activation and polarization","volume":"13","author":"FO Martinez","year":"2008","journal-title":"Frontiers in bioscience: a journal and virtual library"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pt.2004.01.004","article-title":"Alternatively activated macrophages during parasite infections","volume":"20","author":"W Noel","year":"2004","journal-title":"Trends in parasitology"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.176.1.287","article-title":"Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation","volume":"176","author":"M Stein","year":"1992","journal-title":"The Journal of experimental medicine"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"A Mantovani","year":"2002","journal-title":"Trends in immunology"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1182\/blood-2006-07-036210","article-title":"Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation","volume":"110","author":"ML Boulland","year":"2007","journal-title":"Blood"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1073\/pnas.94.6.2507","article-title":"Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis","volume":"94","author":"CC Chu","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.4049\/jimmunol.173.7.4561","article-title":"IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization","volume":"173","author":"JM Mason","year":"2004","journal-title":"Journal of immunology"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/eji.201040428","article-title":"Dichotomy between factors inducing the immunosuppressive enzyme IL-4-induced gene 1 (IL4I1) in B lymphocytes and mononuclear phagocytes","volume":"40","author":"J Marquet","year":"2010","journal-title":"European journal of immunology"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/leu.2008.380","article-title":"The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages","volume":"23","author":"A Carbonnelle-Puscian","year":"2009","journal-title":"Leukemia"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/eji.201041119","article-title":"IL4I1: an inhibitor of the CD8(+) antitumor T-cell response in vivo","volume":"41","author":"F Lasoudris","year":"2011","journal-title":"European journal of immunology"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"e54589","DOI":"10.1371\/journal.pone.0054589","article-title":"Antibacterial properties of the mammalian L-amino acid oxidase IL4I1","volume":"8","author":"ML Puiffe","year":"2013","journal-title":"PloS one"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/sj.gt.3301206","article-title":"Plat-E: an efficient and stable system for transient packaging of retroviruses","volume":"7","author":"S Morita","year":"2000","journal-title":"Gene therapy"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80439-2","article-title":"Stat6 is required for mediating responses to IL-4 and for development of Th2 cells","volume":"4","author":"MH Kaplan","year":"1996","journal-title":"Immunity"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1074-7613(00)80005-9","article-title":"Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils","volume":"10","author":"K Takeda","year":"1999","journal-title":"Immunity"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.gene.2005.04.004","article-title":"Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C\/EBPbeta","volume":"353","author":"MJ Gray","year":"2005","journal-title":"Gene"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.4049\/jimmunol.170.4.1789","article-title":"The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1\/resistin-like molecule alpha gene expression by a STAT6 and CCAAT\/enhancer-binding protein-dependent mechanism","volume":"170","author":"AM Stutz","year":"2003","journal-title":"Journal of immunology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"FO Martinez","year":"2009","journal-title":"Annual review of immunology"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"A Sica","year":"2012","journal-title":"The Journal of clinical investigation"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","article-title":"Inhibition of T cell proliferation by macrophage tryptophan catabolism","volume":"189","author":"DH Munn","year":"1999","journal-title":"The Journal of experimental medicine"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.20020121","article-title":"Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase","volume":"196","author":"G Frumento","year":"2002","journal-title":"The Journal of experimental medicine"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"AL Mellor","year":"2004","journal-title":"Nature reviews Immunology"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1074-7613(00)80072-2","article-title":"Reactive oxygen species regulate activation-induced T cell apoptosis","volume":"10","author":"DA Hildeman","year":"1999","journal-title":"Immunity"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4049\/jimmunol.172.2.989","article-title":"Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species","volume":"172","author":"S Kusmartsev","year":"2004","journal-title":"Journal of immunology"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.4049\/jimmunol.162.6.3256","article-title":"Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells","volume":"162","author":"JM Curtsinger","year":"1999","journal-title":"Journal of immunology"},{"issue":"11","key":"ref32","first-page":"2603","article-title":"Cytokine regulation of human monocyte differentiation in vitro: the tumor-cytotoxic phenotype induced by macrophage colony-stimulating factor is developmentally regulated by gamma-interferon","volume":"53","author":"DH Munn","year":"1993","journal-title":"Cancer research"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4049\/jimmunol.156.2.523","article-title":"Selective activation-induced apoptosis of peripheral T cells imposed by macrophages. A potential mechanism of antigen-specific peripheral lymphocyte deletion","volume":"156","author":"DH Munn","year":"1996","journal-title":"Journal of immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-065X.2008.00608.x","article-title":"Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives","volume":"222","author":"PC Rodriguez","year":"2008","journal-title":"Immunological reviews"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.4049\/jimmunol.160.12.5729","article-title":"Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3\/STAT5 signaling pathway","volume":"160","author":"RM Bingisser","year":"1998","journal-title":"Journal of immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0142979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T19:30:36Z","timestamp":1692127836000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0142979"}},"subtitle":[],"editor":[{"given":"Michal A","family":"Olszewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,24]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0142979","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,24]]}}}