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Wilkin","year":"2008","journal-title":"Dev Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1534\/genetics.107.078394","article-title":"Identification of novel genes that modify phenotypes induced by Alzheimer&apos;s beta-amyloid overexpression in Drosophila","volume":"178","author":"W Cao","year":"2008","journal-title":"Genetics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0896-6273(00)80519-X","article-title":"Mutation in AP-3 \u03b4 in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles","volume":"21","author":"P Kantheti","year":"1998","journal-title":"Neuron"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/hmg\/8.2.323","article-title":"The \u03b23A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night 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Greenspan","year":"1997"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/104454901750070319","article-title":"Molecular analysis of novel Drosophila gene, Gap69C, encoding a homolog of ADP-ribosylation factor GTPase-activating protein","volume":"20","author":"MV Frolov","year":"2001","journal-title":"DNA Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/gb-2012-13-3-r21","article-title":"The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome","volume":"13","author":"RK Cook","year":"2012","journal-title":"Genome Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1139\/gen-42-6-1183","article-title":"A genetic and molecular characterization of the garnet gene of Drosophila melanogaster","volume":"42","author":"VK Lloyd","year":"1999","journal-title":"Genome"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/genetics\/155.1.213","article-title":"Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3\u03b2 adaptin gene ruby","volume":"155","author":"D Kretzschmar","year":"2000","journal-title":"Genetics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/PL00008688","article-title":"Distinct requirements for the AP-3 adaptor complex in pigment granule and synaptic vesicle biogenesis in Drosophila melanogaster","volume":"263","author":"C Mullins","year":"2000","journal-title":"Mol Gen Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/nar\/gkp877","article-title":"Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding","volume":"38","author":"M Silicheva","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e42988","DOI":"10.1371\/journal.pone.0042988","article-title":"The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins","volume":"7","author":"HO Ishikawa","year":"2012","journal-title":"PLoS One"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature05179","article-title":"Prevalence of off-target effects in Drosophila RNA interference screens","volume":"443","author":"Y Ma","year":"2006","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"273473","DOI":"10.1155\/2014\/273473","article-title":"Autophagy in Drosophila: from historical studies to current knowledge","volume":"2014","author":"NC Mulakkal","year":"2014","journal-title":"Biomed Res 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One"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ng.2497","article-title":"Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy","volume":"45","author":"T Cullup","year":"2013","journal-title":"Nat Genet"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/jid.2014.439","article-title":"Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes","volume":"135","author":"CF Zhang","year":"2015","journal-title":"J Invest Dermatol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1242\/dev.00522","article-title":"Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development","volume":"130","author":"CC Jang","year":"2003","journal-title":"Development"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2010.07.002","article-title":"Models for the functions of Arf GAPs","volume":"22","author":"MP East","year":"2011","journal-title":"Semin Cell Dev Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1600-0854.2007.00624.x","article-title":"Arf GAPs and their interacting proteins","volume":"8","author":"H Inoue","year":"2007","journal-title":"Traffic"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1083\/jcb.142.2.391","article-title":"ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes","volume":"142","author":"CE Ooi","year":"1998","journal-title":"J Cell Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0092-8674(00)81170-8","article-title":"A function for the AP3 coat complex in synaptic vesicle formation from endosomes","volume":"93","author":"V Fa\u00fandez","year":"1998","journal-title":"Cell"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1091\/mbc.11.11.3723","article-title":"The assembly of AP-3 adaptor complex-containing clathrin-coated vesicles on synthetic liposomes","volume":"11","author":"MT Drake","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1021\/bi016064j","article-title":"Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3","volume":"41","author":"C Austin","year":"2002","journal-title":"Biochemistry"},{"key":"ref92","first-page":"47","article-title":"GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila","volume":"1603","author":"A Bernards","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1083\/jcb.200907122","article-title":"AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis","volume":"187","author":"C Delevoye","year":"2009","journal-title":"J Cell Biol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbrc.2010.03.017","article-title":"ArfGAP1 interacts with coat proteins through tryptophan-based motifs","volume":"394","author":"M Rawet","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cub.2010.12.010","article-title":"AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors","volume":"21","author":"N Benhra","year":"2011","journal-title":"Curr Biol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1523\/JNEUROSCI.4566-11.2012","article-title":"ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2","volume":"32","author":"Y Xiong","year":"2012","journal-title":"J Neurosci"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"e1002526","DOI":"10.1371\/journal.pgen.1002526","article-title":"GTPase activity and neuronal toxicity of Parkinson&apos;s disease-associated LRRK2 is regulated by ArfGAP1","volume":"8","author":"K Stafa","year":"2012","journal-title":"PLoS Genet"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1073\/pnas.1004676107","article-title":"Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice","volume":"107","author":"Y Tong","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/hmg\/ddr481","article-title":"Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP","volume":"21","author":"P G\u00f3mez-Suaga","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/hmg\/ddr573","article-title":"Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning","volume":"21","author":"MW Dodson","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1242\/dmm.017020","article-title":"Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo","volume":"7","author":"MW Dodson","year":"2014","journal-title":"Dis Model Mech"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuron.2012.11.033","article-title":"RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson&apos;s disease risk","volume":"77","author":"DA MacLeod","year":"2013","journal-title":"Neuron"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"e111632","DOI":"10.1371\/journal.pone.0111632","article-title":"LRRK2 transport is regulated by its novel interacting partner Rab32","volume":"9","author":"D Waschb\u00fcsch","year":"2014","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T12:44:41Z","timestamp":1718196281000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143026"}},"subtitle":[],"editor":[{"given":"Fanis","family":"Missirlis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,13]]},"references-count":103,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143026","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,13]]}}}