{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:43:37Z","timestamp":1793033017655,"version":"4.5.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T00:00:00Z","timestamp":1447632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0143064","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T22:43:05Z","timestamp":1447713785000},"page":"e0143064","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling Pathway"],"prefix":"10.1371","volume":"10","author":[{"given":"Ma","family":"Ruisong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Xiaorong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Gangying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chunfeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Changjiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xuefei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuanhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,11,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1161\/CIRCULATIONAHA.108.769331","article-title":"High-mobility group box-1 in ischemia-reperfusion injury of the heart","volume":"117","author":"M Andrassy","year":"2008","journal-title":"Circulation"},{"key":"ref2","first-page":"2720","article-title":"Cholinergic anti-inflammatory pathway: a possible approach to protect against myocardial ischemia reperfusion injury","volume":"123","author":"J Xiong","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e108024","DOI":"10.1371\/journal.pone.0108024","article-title":"Etanercept attenuates myocardial ischemia\/reperfusion injury by decreasing inflammation and oxidative stress","volume":"9","author":"M Yang","year":"2014","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"J Schmitz","year":"2005","journal-title":"Immunity"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.ajpath.2012.06.003","article-title":"The alarmin IL-33 is a notch target in quiescent endothelial cells","volume":"181","author":"E Sundlisaeter","year":"2012","journal-title":"Am J Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCHEARTFAILURE.109.873240","article-title":"Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling","volume":"2","author":"K Seki","year":"2009","journal-title":"Circ Heart Fail"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e56089","DOI":"10.1371\/journal.pone.0056089","article-title":"IL-33 attenuates anoxia\/reoxygenation-induced cardiomyocyte apoptosis by inhibition of PKCbeta\/JNK pathway","volume":"8","author":"T Rui","year":"2013","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/cvr\/cvs015","article-title":"Reduction in IL-33 expression exaggerates ischaemia\/reperfusion-induced myocardial injury in mice with diabetes mellitus","volume":"94","author":"T Rui","year":"2012","journal-title":"Cardiovasc Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-9255-8-22","article-title":"Role of IL-33 in inflammation and disease","volume":"8","author":"AM Miller","year":"2011","journal-title":"J Inflamm (Lond)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/TA.0000000000000588","article-title":"Ketamine reduces LPS-induced HMGB1 via activation of the Nrf2\/HO-1 pathway and NF-kappaB suppression","volume":"78","author":"Y Tan","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jss.2013.02.051","article-title":"Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia\/reperfusion injury in vivo","volume":"183","author":"J Wang","year":"2013","journal-title":"J Surg Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bcp.2011.06.041","article-title":"Beta(1)-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice","volume":"82","author":"YM Ha","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11033-011-0730-5","article-title":"Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats","volume":"39","author":"X Hu","year":"2012","journal-title":"Mol Biol Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.4049\/jimmunol.0902660","article-title":"The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4\/phosphatidylinositol 3-kinase gamma pathway","volume":"184","author":"H Xu","year":"2010","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI30634","article-title":"IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system","volume":"117","author":"S Sanada","year":"2007","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.jacc.2008.09.027","article-title":"Nonmyocardial production of ST2 protein in human hypertrophy and failure is related to diastolic load","volume":"52","author":"J Bartunek","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/hep.25768","article-title":"Interleukin-33 is hepatoprotective during liver ischemia\/reperfusion in mice","volume":"56","author":"N Sakai","year":"2012","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/TP.0b013e3181d720af","article-title":"IL-33 prolongs murine cardiac allograft survival through induction of TH2-type immune deviation","volume":"89","author":"H Yin","year":"2010","journal-title":"Transplantation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3760\/cma.j.issn.0366-6999.20123530","article-title":"Pretreatment with interleukin-33 reduces warm hepatic ischemia\/reperfusion injury in mice","volume":"126","author":"S Li","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e88742","DOI":"10.1371\/journal.pone.0088742","article-title":"The alarmin concept applied to human renal transplantation: evidence for a differential implication of HMGB1 and IL-33","volume":"9","author":"A Thierry","year":"2014","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2010.03.059","article-title":"Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats","volume":"638","author":"X Hu","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s10753-014-9895-0","article-title":"Anti-inflammatory effect of B-type natriuretic peptide postconditioning during myocardial ischemia-reperfusion: involvement of PI3K\/Akt signaling pathway","volume":"37","author":"G Hu","year":"2014","journal-title":"Inflammation"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yjmcc.2015.01.007","article-title":"Depletion of PHD3 protects heart from ischemia\/reperfusion injury by inhibiting cardiomyocyte apoptosis","volume":"80","author":"L Xie","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.gene.2013.05.041","article-title":"The HMGB1-TLR4 axis contributes to myocardial ischemia\/reperfusion injury via regulation of cardiomyocyte apoptosis","volume":"527","author":"HS Ding","year":"2013","journal-title":"Gene"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1097\/TP.0b013e318293b7e1","article-title":"Hmgb1-TLR4-IL-23-IL-17A axis promote ischemia-reperfusion injury in a cardiac transplantation model","volume":"95","author":"H Zhu","year":"2013","journal-title":"Transplantation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11010-014-2213-1","article-title":"Urocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection","volume":"398","author":"XF Gao","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biocel.2009.10.021","article-title":"Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1","volume":"42","author":"A Yndestad","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2014.02.014","article-title":"An increase of interleukin-33 serum levels after coronary stent implantation is associated with coronary in-stent restenosis","volume":"67","author":"S Demyanets","year":"2014","journal-title":"Cytokine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.ijcard.2012.05.073","article-title":"Pre-discharge risk stratification in unselected STEMI: is there a role for ST2 or its natural ligand IL-33 when compared with contemporary risk markers?","volume":"167","author":"OS Dhillon","year":"2013","journal-title":"Int J Cardiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:42:17Z","timestamp":1718199737000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143064"}},"subtitle":[],"editor":[{"given":"Meijing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,16]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143064","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,16]]}}}