{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:37:28Z","timestamp":1790505448781,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0143073","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T19:03:36Z","timestamp":1449083016000},"page":"e0143073","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia"],"prefix":"10.1371","volume":"10","author":[{"given":"Jos\u00e9 \u00c1ngel","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Hern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Eugenia","family":"Rodr\u00edguez-Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Grossmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Collado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Heras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Puiggros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana \u00c1frica","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Robledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Queiz\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Galende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"de la Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Mart\u00edn-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Abrisqueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Lu\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Marug\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Gonz\u00e1lez-Gasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kohlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Espinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Mar\u00eda","family":"Hern\u00e1ndez-Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Grupo Cooperativo Espa\u00f1ol de Citogen\u00e9tica Hematol\u00f3gica (GCECGH) and Grupo Espa\u00f1ol de Leucemia Linf\u00e1tica Cr\u00f3nica (GELLC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","article-title":"Genomic aberrations and survival in chronic lymphocytic leukemia","volume":"343","author":"H Dohner","year":"2000","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3324\/haematol.13862","article-title":"A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia","volume":"94","author":"JA Hernandez","year":"2009","journal-title":"Haematologica"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1182\/blood.V89.7.2516","article-title":"11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis","volume":"89","author":"H Dohner","year":"1997","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/bjh.12534","article-title":"Patients with chronic lymphocytic leukaemia and clonal deletion of both 17p13.1 and 11q22.3 have a very poor prognosis","volume":"163","author":"PT Greipp","year":"2013","journal-title":"Br J Haematol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/cncr.23993","article-title":"Chemoimmunotherapy may overcome the adverse prognostic significance of 11q deletion in previously untreated patients with chronic lymphocytic leukemia","volume":"115","author":"AM Tsimberidou","year":"2009","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"11837","DOI":"10.1073\/pnas.93.21.11837","article-title":"Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3\u2013923.1 in lymphoproliferative disorders","volume":"93","author":"S Stilgenbauer","year":"1996","journal-title":"P Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrm2858","article-title":"Genomic instability\u2014an evolving hallmark of cancer","volume":"11","author":"S Negrini","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref8","first-page":"24","article-title":"ATM mutations in B-cell chronic lymphocytic leukemia","volume":"59","author":"F Bullrich","year":"1999","journal-title":"Cancer research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3324\/haematol.2013.098574","article-title":"ATM mutation rather than BIRC3 deletion and\/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial","volume":"99","author":"MJ Rose-Zerilli","year":"2014","journal-title":"Haematologica"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood.V94.2.748","article-title":"Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia","volume":"94","author":"C Schaffner","year":"1999","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1084\/jem.20110921","article-title":"Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation","volume":"208","author":"G Fabbri","year":"2011","journal-title":"J Exp Med"},{"issue":"7354","key":"ref12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature10113","article-title":"Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia","volume":"475","author":"XS Puente","year":"2011","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.1032","article-title":"Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia","volume":"44","author":"V Quesada","year":"2012","journal-title":"Nat genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1109016","article-title":"SF3B1 and other novel cancer genes in chronic lymphocytic leukemia","volume":"365","author":"L Wang","year":"2011","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/leu.2008.274","article-title":"The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype","volume":"23","author":"F Dicker","year":"2009","journal-title":"Leukemia"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1158\/1078-0432.CCR-08-1630","article-title":"The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness","volume":"15","author":"D Rossi","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/leu.2012.307","article-title":"NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia","volume":"27","author":"L Mansouri","year":"2013","journal-title":"Leukemia"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1182\/blood-2011-09-379966","article-title":"Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia","volume":"119","author":"D Rossi","year":"2012","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/leu.2013.263","article-title":"SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients","volume":"28","author":"S Jeromin","year":"2014","journal-title":"Leukemia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1182\/blood-2012-09-458265","article-title":"Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia","volume":"121","author":"D Rossi","year":"2013","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1182\/blood-2011-12-395673","article-title":"Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia","volume":"119","author":"D Rossi","year":"2012","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/gcc.20885","article-title":"13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia","volume":"50","author":"M Dal Bo","year":"2011","journal-title":"Genes, chromosomes cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/bjh.12479","article-title":"Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic leukaemia: analysis of 627 patients with isolated 13q deletion","volume":"163","author":"A Puiggros","year":"2013","journal-title":"Br J Haematol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1365-2141.2009.07982.x","article-title":"A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia","volume":"148","author":"DL Van Dyke","year":"2010","journal-title":"Br J Haematol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines","volume":"111","author":"M Hallek","year":"2008","journal-title":"Blood"},{"key":"ref26","first-page":"1213","article-title":"The value of fluorescence in situ hybridization for the detection of 11q in multiple myeloma","volume":"89","author":"MB Gonzalez","year":"2004","journal-title":"Haematologica"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"M Margulies","year":"2005","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jmoldx.2013.03.003","article-title":"Robustness of amplicon deep sequencing underlines its utility in clinical applications","volume":"15","author":"V Grossmann","year":"2013","journal-title":"J Mol Diagn"},{"key":"ref29","article-title":"A high proportion of cells carrying trisomy 12 is associated with a worse outcome in patients with chronic lymphocytic leukemia","author":"YMI Gonzalez-Gascon","year":"2015","journal-title":"Hematol Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cancergen.2013.01.003","article-title":"Chronic lymphocytic leukemia: a clinical and molecular heterogenous disease","volume":"206","author":"AE Rodriguez-Vicente","year":"2013","journal-title":"Cancer genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1182\/blood-2009-03-210591","article-title":"De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience","volume":"114","author":"CS Tam","year":"2009","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(07)61125-8","article-title":"Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial","volume":"370","author":"D Catovsky","year":"2007","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ajh.23978","article-title":"High FISH percentage of deletion 11q in patients with chronic lymphocytic leukemia is an independent predictor of adverse outcome","volume":"90","author":"P Jain","year":"2015","journal-title":"Am J Hematol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/hon.2028","article-title":"Clinical heterogeneity of de novo 11q deletion chronic lymphocytic leukaemia: prognostic relevance of extent of 11q deleted nuclei inside leukemic clone","volume":"31","author":"R Marasca","year":"2013","journal-title":"Hematol Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5448","DOI":"10.1200\/JCO.2007.11.2649","article-title":"Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion","volume":"25","author":"B Austen","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3324\/haematol.2012.081620","article-title":"ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin","volume":"98","author":"V Navrkalova","year":"2013","journal-title":"Haematologica"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1200\/JCO.2011.41.0852","article-title":"Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial","volume":"30","author":"A Skowronska","year":"2012","journal-title":"J Clin Oncol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1182\/blood-2012-05-429282","article-title":"The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial","volume":"121","author":"DG Oscier","year":"2013","journal-title":"Blood"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1038\/leu.2013.218","article-title":"Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients","volume":"27","author":"S Weissmann","year":"2013","journal-title":"Leukemia"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2013.01.019","article-title":"Evolution and impact of subclonal mutations in chronic lymphocytic leukemia","volume":"152","author":"DA Landau","year":"2013","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"B Vogelstein","year":"2013","journal-title":"Science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T05:19:15Z","timestamp":1599887955000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143073"}},"subtitle":[],"editor":[{"given":"Spencer B.","family":"Gibson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,2]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143073","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,2]]}}}