{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:40:58Z","timestamp":1761597658723},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0143103","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T19:19:36Z","timestamp":1449083976000},"page":"e0143103","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["T-Tau and P-Tau in Brain and Blood from Natural and Experimental Prion Diseases"],"prefix":"10.1371","volume":"10","author":[{"given":"Richard","family":"Rubenstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binggong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/oxfordjournals.bmb.a072649","article-title":"Scrapie strain variation and mutation","volume":"49","author":"ME Bruce","year":"1993","journal-title":"Br Med Bull"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00266934","article-title":"Host genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent","volume":"112","author":"AG Dickinson","year":"1971","journal-title":"Mol Gen Genet"},{"key":"ref3","first-page":"3","article-title":"Slow infections of the central nervous system","author":"AG Dickinson","year":"1977"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0022-510X(83)90021-7","article-title":"Disinfection studies with two strains of mouse-passaged scrapie agent","volume":"59","author":"RH Kimberlin","year":"1983","journal-title":"J Neurol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1099\/0022-1317-68-1-79","article-title":"Biological evidence that scrapie agent has an independent genome","volume":"68","author":"ME Bruce","year":"1987","journal-title":"J Gen Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1099\/0022-1317-68-3-695","article-title":"Incubation periods and survival times for mice injected stereotaxically with three scrapie strains in different brain regions","volume":"68","author":"YS Kim","year":"1987","journal-title":"J Gen Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3181\/00379727-189-42774","article-title":"Adrenal involvement in scrapie-induced obesity","volume":"189","author":"YS Kim","year":"1988","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref8","first-page":"63","article-title":"Novel infectious agents and the central nervous system, Ciba Foundation Symposium 135","author":"AG Dickinson","year":"1988"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000149503","article-title":"Preclinical changes in weight of scrapie-infected mice as a function of scrapie agent-mouse strain combination","volume":"21","author":"RI Carp","year":"1984","journal-title":"Intervirology"},{"key":"ref10","first-page":"567","article-title":"Classic genetics of scrapie","volume":"317","author":"RI Carp","year":"1989","journal-title":"Prog Clin Biol Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0021-9975(68)90006-6","article-title":"The sequential development of the brain lesions of scrapie in three strains of mice","volume":"78","author":"H Fraser","year":"1968","journal-title":"J Comp Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1099\/0022-1317-72-3-595","article-title":"The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis","volume":"72","author":"ME Bruce","year":"1991","journal-title":"J Gen Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2990.2000.026002143.x","article-title":"Dendritic and synaptic alterations of hippocampal pyramidal neurons in scrapie-infected mice","volume":"26","author":"PV Belichenko","year":"2000","journal-title":"Neuropath Appl Neurobiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2990.2000.00216.x","article-title":"Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus","volume":"26","author":"M Jeffrey","year":"2000","journal-title":"Neuropath Appl Neurobiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00001756-200101220-00043","article-title":"Early loss of dendritic spines in murine scrapie revealed by confocal analysis","volume":"12","author":"D Brown","year":"2001","journal-title":"NeuroReport"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.nbd.2009.04.001","article-title":"Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology","volume":"35","author":"BC Gray","year":"2009","journal-title":"Neurobiol Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1046\/j.1460-9568.2003.02662.x","article-title":"Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease","volume":"17","author":"C Cunningham","year":"2003","journal-title":"Eur J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1042\/BST0380545","article-title":"Change if tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease","volume":"38","author":"AA Asuni","year":"2010","journal-title":"Biochem Soc Trans"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7471","DOI":"10.1523\/JNEUROSCI.22-17-07471.2002","article-title":"Unhampered Prion Neuroinvasion despite Impaired Fast Axonal Transport in Transgenic Mice Overexpressing Four-Repeat Tau","volume":"22","author":"V K\u00fcnzi","year":"2002","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.neurobiolaging.2007.04.026","article-title":"Tauopathy in human and experimental variant Creutzfeldt-Jakob disease","volume":"29","author":"G Giaccone","year":"2008","journal-title":"Neurol Aging"},{"key":"ref21","first-page":"139","article-title":"Current Topics in Microbiology and Immunology, vol. 172, Transmissible Spongiform Encephalopathies","author":"RJ Kascsak","year":"1991"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1128\/JVI.59.3.676-683.1986","article-title":"Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains","volume":"59","author":"RJ Kascsak","year":"1986","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1089\/neu.2014.3548","article-title":"A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids","volume":"32","author":"R Rubenstein","year":"2014","journal-title":"J Neurotrauma"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/82868","article-title":"Neurotrophins are required for nerve growth during development","volume":"4","author":"KL Tucker","year":"2001","journal-title":"Nat Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/78078","article-title":"Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein","volume":"25","author":"J Lewis","year":"2000","journal-title":"Nature Genetics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.mp.4001220","article-title":"Phospho-tau\/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt\u2013Jakob disease from other dementias","volume":"8","author":"M Riemenschneider","year":"2003","journal-title":"Mol Psy"},{"key":"ref27","first-page":"1147","article-title":"Diagnostic value of 14-3-3beta immunoblot and T-tau\/P-tau ratio in clinically suspected Creutzfeldt-Jakob disease","volume":"16","author":"K Blennow","year":"2005","journal-title":"Int J Mol Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1007\/s00415-011-5960-x","article-title":"Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease","volume":"258","author":"M Noguchi-Shinohara","year":"2011","journal-title":"J Neurol"},{"key":"ref29","first-page":"476","article-title":"Diagnostic performance of cerebrospinal fluid total tau and phosphorylated tau in Creutzfeldt-Jakob Disease. Results from the Swedish mortality registry","volume":"71","author":"T Skillback","year":"2014","journal-title":"JAMA"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbadis.2004.09.008","article-title":"Tau pathology in Alzheimer disease and other tauopathies","volume":"1739","author":"K Iqbal","year":"2005","journal-title":"Mol Basis Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00005072-198311000-00002","article-title":"Increased blood-brain barrier permeability in scrapie-infected mice","volume":"42","author":"HM Wisniewski","year":"1983","journal-title":"J. Neuropath Exp Neurol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/jnnp.73.1.79","article-title":"Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt\u2013Jakob disease","volume":"73","author":"B Van Everbroeck","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s00401-002-0547-3","article-title":"Hyperphosphorylated tau deposits parallels prion protein burden in a case of Gerstmann-Straussler-Scheinker syndrome P102L mutation complicated with dementia","volume":"104","author":"K Ishizawa","year":"2002","journal-title":"Acta Neuropathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11010-007-9664-6","article-title":"Human tau protein forms complex with PrP and some GSS- and fCJD-related PrP mutants possess stronger binding activities with tau in vitro","volume":"310","author":"XF Wang","year":"2008","journal-title":"Mol and Cell Biochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.vetmic.2006.02.017","article-title":"BSE infection in bovine PrP transgenic mice leads to hyperphosphorylation of tau-protein","volume":"15","author":"MJ Bautista","year":"2006","journal-title":"Vet Microbiol"},{"key":"ref36","first-page":"199","article-title":"Magnetic resonance spectroscopy and measurement of tau epitopes of autopsy proven sporadic Creutzfeldt-Jakob disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 immunoblot","volume":"32","author":"H Sarac","year":"2008","journal-title":"Coll Antropol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neurobiolaging.2012.05.010","article-title":"Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models","volume":"34","author":"CM Acker","year":"2013","journal-title":"Neurobiol Aging"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jviromet.2009.02.019","article-title":"Surround optical fiber immunoassay (SOFIA): an ultra-sensitive assay for prion protein detection","volume":"159","author":"B Chang","year":"2009","journal-title":"J Virol Methods"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T05:21:12Z","timestamp":1599888072000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143103"}},"subtitle":[],"editor":[{"given":"Byron","family":"Caughey","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,2]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143103","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,2]]}}}