{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:06:46Z","timestamp":1779120406588,"version":"3.51.4"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0143134","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T18:56:33Z","timestamp":1447872993000},"page":"e0143134","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Equivalence between Two Commercially Available S499-Phosphorylated FMRP Antibodies in Mice"],"prefix":"10.1371","volume":"10","author":[{"given":"Conner D.","family":"Reynolds","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor S.","family":"Jefferson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquin N.","family":"Lugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","article-title":"Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome","volume":"65","author":"AJ Verkerk","year":"1991","journal-title":"Cell"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ejhg.2008.61","article-title":"Fragile X syndrome","volume":"16","author":"KB Garber","year":"2008","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/ejhg.2010.135","article-title":"Preparation and validation of the first WHO international genetic reference panel for Fragile X syndrome","volume":"19","author":"M Hawkins","year":"2011","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1542\/peds.2010-3500","article-title":"Health supervision for children with fragile X syndrome","volume":"127","author":"JH Hersh","year":"2011","journal-title":"Pediatrics"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/ar.21299","article-title":"Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism","volume":"294","author":"SH Fatemi","year":"2011","journal-title":"Anatomical record"},{"issue":"1\u20133","key":"ref6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.schres.2010.07.017","article-title":"Fragile X mental retardation protein levels are decreased in major psychiatric disorders","volume":"124","author":"SH Fatemi","year":"2010","journal-title":"Schizophrenia research"},{"key":"ref7","article-title":"Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures","author":"PB Bernard","year":"2013","journal-title":"Neurobiol Dis"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/hmg\/10.4.329","article-title":"Evidence that fragile X mental retardation protein is a negative regulator of translation","volume":"10","author":"B Laggerbauer","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"24","key":"ref9","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1093\/hmg\/ddg350","article-title":"Phosphorylation influences the translation state of FMRP-associated polyribosomes","volume":"12","author":"S Ceman","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"S Wullschleger","year":"2006","journal-title":"Cell"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"33","author":"CA Hoeffer","year":"2010","journal-title":"Trends Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Owonikoko TK, Khuri FR. Targeting the PI3K\/AKT\/mTOR pathway: biomarkers of success and tribulation. American Society of Clinical Oncology educational book \/ ASCO American Society of Clinical Oncology Meeting. 2013.","DOI":"10.1200\/EdBook_AM.2013.33.e395"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1101\/lm.027664.112","article-title":"A recollection of mTOR signaling in learning and memory","volume":"20","author":"TE Graber","year":"2013","journal-title":"Learn Mem"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1523\/JNEUROSCI.3696-09.2010","article-title":"Dysregulation of mTOR signaling in fragile X syndrome","volume":"30","author":"A Sharma","year":"2010","journal-title":"J Neurosci"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ng782","article-title":"Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease","volume":"29","author":"SA Backman","year":"2001","journal-title":"Nat Genet"},{"key":"ref16","article-title":"PTEN signaling in autism spectrum disorders","author":"J Zhou","year":"2012","journal-title":"Curr Opin Neurobiol"},{"key":"ref17","first-page":"27","article-title":"Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins","volume":"7","author":"JN Lugo","year":"2014","journal-title":"Front Mol Neurosci"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1101\/lm.032839.113","article-title":"Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein","volume":"20","author":"JN Lugo","year":"2013","journal-title":"Learning & Memory"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nbt.2712","article-title":"Phospho-specific antibodies by design","volume":"31","author":"O Stoevesandt","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng781","article-title":"Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease","volume":"29","author":"CH Kwon","year":"2001","journal-title":"Nat Genet"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1111\/j.1471-4159.2008.05508.x","article-title":"Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus","volume":"106","author":"JN Lugo","year":"2008","journal-title":"J Neurochem"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"e96956","DOI":"10.1371\/journal.pone.0096956","article-title":"FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity","volume":"9","author":"CM Bartley","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2144\/000113382","article-title":"Antibody validation","volume":"48","author":"J Bordeaux","year":"2010","journal-title":"Biotechniques"},{"issue":"21","key":"ref24","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.1002\/j.1460-2075.1995.tb00220.x","article-title":"The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2","volume":"14","author":"Y Zhang","year":"1995","journal-title":"EMBO J"},{"issue":"24","key":"ref25","doi-asserted-by":"crossref","first-page":"8438","DOI":"10.1128\/MCB.22.24.8438-8447.2002","article-title":"Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties","volume":"22","author":"MC Siomi","year":"2002","journal-title":"Mol Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T17:37:05Z","timestamp":1567359425000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143134"}},"subtitle":[],"editor":[{"given":"Ellen R","family":"Goldman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,18]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143134","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,18]]}}}