{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:53:32Z","timestamp":1789451612267,"version":"build-2803163510"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0143316","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T19:53:37Z","timestamp":1448049217000},"page":"e0143316","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":161,"title":["Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation"],"prefix":"10.1371","volume":"10","author":[{"given":"Daichi","family":"Maeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kunita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Katoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiteru","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Igawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fukayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/ncpuro0874","article-title":"Interstitial cystitis and systemic autoimmune diseases","volume":"4","author":"JP van de Merwe","year":"2007","journal-title":"Nat Clin Pract Urol"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/nau.22348","article-title":"A case-control study on the association between rheumatoid arthritis and bladder pain syndrome\/interstitial cystitis","volume":"32","author":"JJ Keller","year":"2013","journal-title":"Neurourol Urodyn"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1016\/S0022-5347(05)65006-9","article-title":"Toward a precise definition of interstitial cystitis: further evidence of differences in classic and nonulcer disease","volume":"167","author":"R Peeker","year":"2002","journal-title":"J Urol"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0090-4295(01)01101-3","article-title":"Clinical characteristics support that interstitial cystitis is a heterogeneous syndrome","volume":"57","author":"M Fall","year":"2001","journal-title":"Urology"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S0022-5347(17)39611-8","article-title":"Interstitial cystitis: bladder mucosa lymphocyte immunophenotyping and peripheral blood flow cytometry analysis","volume":"144","author":"DS Harrington","year":"1990","journal-title":"J Urol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-5347(17)43863-8","article-title":"Chronic interstitial cystitis: a heterogeneous syndrome","volume":"137","author":"M Fall","year":"1987","journal-title":"J Urol"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/00000478-199010000-00011","article-title":"The histology of interstitial cystitis","volume":"14","author":"WL Lynes","year":"1990","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0022-5347(17)41529-1","article-title":"Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on Interstitial Cystitis, National Institutes of Health, Bethesda, Maryland, August 28\u201329, 1987","volume":"140","author":"JY Gillenwater","year":"1988","journal-title":"J Urol"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1442-2042.2009.02326.x","article-title":"Clinical guidelines for interstitial cystitis and hypersensitive bladder syndrome","volume":"16","author":"Y Homma","year":"2009","journal-title":"Int J Urol"},{"issue":"3","key":"ref10","first-page":"133","article-title":"Limitations of numerical ratios for defining monoclonality of immunoglobulin light chains in B-cell lymphomas","volume":"3","author":"MK Samoszuk","year":"1985","journal-title":"Diagn Immunol"},{"key":"ref11","article-title":"Lehrbuch der Kystoskopie: Ihre Technik und Lkinische Bedeuting","author":"M Nitze","year":"1907"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1056\/NEJM191505061721802","article-title":"A rare type of bladder ulcer in women; report of cases","author":"GL Hunner","year":"1915","journal-title":"Boston Med Surg J"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0090-4295(78)90286-8","article-title":"Interstitial cystitis: early diagnosis, pathology, and treatment","volume":"12","author":"EM Messing","year":"1978","journal-title":"Urology"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","article-title":"Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal","volume":"53","author":"JP van de Merwe","year":"2008","journal-title":"Eur Urol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/nau.20687","article-title":"Status of international consensus on interstitial cystitis\/bladder pain syndrome\/painful bladder syndrome: 2008 snapshot","volume":"28","author":"P Hanno","year":"2009","journal-title":"Neurourol Urodyn"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1464-410X.1991.tb15068.x","article-title":"Can histological assessment predict the outcome in interstitial cystitis?","volume":"67","author":"JP MacDermott","year":"1991","journal-title":"Br J Urol"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/00365599.2012.699100","article-title":"Bladder pain syndrome\/interstitial cystitis ESSIC type 3C: high expression of inducible nitric oxide synthase in inflammatory cells","volume":"47","author":"Y Logadottir","year":"2013","journal-title":"Scand J Urol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/003655998750015179","article-title":"Decreased levels of S-100 protein in non-ulcer interstitial cystitis","volume":"32","author":"R Peeker","year":"1998","journal-title":"Scand J Urol Nephrol"},{"issue":"Suppl 1","key":"ref19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/iju.12370","article-title":"Inflammation characteristics in bladder pain syndrome ESSIC type 3C\/classic interstitial cystitis","volume":"21","author":"Y Logadottir","year":"2014","journal-title":"Int J Urol"},{"issue":"Suppl","key":"ref20","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1046\/j.1442-2042.10.s1.1.x","article-title":"The legendary beginning of the International Consultation on Interstitial Cystitis","volume":"10","author":"T Ueda","year":"2003","journal-title":"Int J Urol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0022-5347(17)39933-0","article-title":"Diagnosis of interstitial cystitis","volume":"143","author":"P Hanno","year":"1990","journal-title":"J Urol"},{"issue":"Suppl 1","key":"ref22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/iju.12325","article-title":"Interstitial cystitis is bladder pain syndrome with Hunner&apos;s lesion","volume":"21","author":"M Fall","year":"2014","journal-title":"Int J Urol"},{"issue":"2","key":"ref23","first-page":"122","article-title":"Interstitial cystitis with plasma cell bladder infiltration: case report and literature review","volume":"82","author":"M Pacella","year":"2010","journal-title":"Arch Ital Urol Androl"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1464-410X.1994.tb07635.x","article-title":"Lymphocyte sub-populations in the bladder wall in normal bladder, bacterial cystitis and interstitial cystitis","volume":"73","author":"TJ Christmas","year":"1994","journal-title":"Br J Urol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1471-2164-10-199","article-title":"Gene expression profile of bladder tissue of patients with ulcerative interstitial cystitis","volume":"10","author":"M Gamper","year":"2009","journal-title":"BMC Genomics"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00192-013-2112-0","article-title":"Local immune response in bladder pain syndrome\/interstitial cystitis ESSIC type 3C","volume":"24","author":"M Gamper","year":"2013","journal-title":"Int Urogynecol J"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.autrev.2007.02.013","article-title":"Infections, B cell receptor activation and autoimmunity: different check-point impairments lead to autoimmunity, clonal B cell expansion and fibrosis in different immunological settings","volume":"7","author":"G Ferraccioli","year":"2007","journal-title":"Autoimmun Rev"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1182\/blood.V91.6.1864","article-title":"Clonal salivary gland infiltrates associated with myoepithelial sialadenitis (Sj\u00f6gren&apos;s syndrome) begin as nonmalignant antigen-selected expansions","volume":"91","author":"DW Bahler","year":"1998","journal-title":"Blood"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/annrheumdis-2012-202861","article-title":"Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity","volume":"73","author":"ME Doorenspleet","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1002\/hep.26232","article-title":"Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis","volume":"57","author":"Wenniger LJ Maillette de Buy","year":"2013","journal-title":"Hepatology"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.4049\/jimmunol.171.5.2725","article-title":"Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid","volume":"171","author":"GP Owens","year":"2003","journal-title":"J Immunol"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3748\/wjg.v20.i3.684","article-title":"Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas","volume":"20","author":"MI Pereira","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/00365599.2010.515613","article-title":"Does mast cell density predict the outcome after transurethral resection of Hunner&apos;s lesions in patients with type 3C bladder pain syndrome\/interstitial cystitis?","volume":"44","author":"J R\u00f6ssberger","year":"2010","journal-title":"Scand J Urol Nephrol"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/S0022-5347(05)66915-7","article-title":"Comparison of cystoscopic and histological findings in patients with suspected interstitial cystitis","volume":"164","author":"MA Denson","year":"2000","journal-title":"J Urol"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0090-4295(01)01166-9","article-title":"Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study","volume":"57","author":"JE Tomaszewski","year":"2001","journal-title":"Urology"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.juro.2006.08.096","article-title":"Discovery of morphological subgroups that correlate with severity of symptoms in interstitial cystitis: a proposed biopsy classification system","volume":"177","author":"BE Leiby","year":"2007","journal-title":"J Urol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T16:53:30Z","timestamp":1599843210000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143316"}},"subtitle":[],"editor":[{"given":"Robert","family":"Hurst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,20]]},"references-count":36,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143316","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,20]]}}}