{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:11:46Z","timestamp":1790136706024,"version":"4.0.1"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0143651","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T21:44:22Z","timestamp":1448401462000},"page":"e0143651","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Inter-Relationship between Rhinitis and Conjunctivitis in Allergic Rhinoconjunctivitis and Associated Risk Factors in Rural UK Children"],"prefix":"10.1371","volume":"10","author":[{"given":"Michael R.","family":"Perkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja R.","family":"Rudnicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Strachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/bmj.315.7111.816","article-title":"Managing eye conditions in general practice","volume":"315","author":"T Manners","year":"1997","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jaci.2004.10.042","article-title":"Allergic conjunctivitis: update on pathophysiology and prospects for future treatment","volume":"115","author":"SJ Ono","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1076\/opep.11.1.17.26437","article-title":"Economic and quality-of-life impact of seasonal allergic conjunctivitis in Oxfordshire","volume":"11","author":"AD Pitt","year":"2004","journal-title":"Ophthalmic Epidemiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2222.2004.1935.x","article-title":"Burden of allergic disease in the UK: secondary analyses of national databases","volume":"34","author":"R Gupta","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2007.03.034","article-title":"Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study","volume":"120","author":"S Walker","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jaci.2003.12.591","article-title":"Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003","volume":"113","author":"SG Johansson","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jaci.2010.06.050","article-title":"The epidemiology of ocular and nasal allergy in the United States, 1988\u20131994","volume":"126","author":"K Singh","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1399-3038.1997.tb00156.x","article-title":"Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"8","author":"D Strachan","year":"1997","journal-title":"Pediatr Allergy Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ppul.21061","article-title":"Very low prevalence of asthma and allergies in schoolchildren from rural Beijing, China","volume":"44","author":"Y Ma","year":"2009","journal-title":"Pediatr Pulmonol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1651-2227.2002.tb00122.x","article-title":"Does heredity modify the association between farming and allergy in children?","volume":"91","author":"ST Remes","year":"2002","journal-title":"Acta Paediatr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jaci.2009.09.019","article-title":"Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study","volume":"125","author":"PI Pfefferle","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1398-9995.2005.00939.x","article-title":"Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle\u2014the PARSIFAL study","volume":"61","author":"T Alfven","year":"2006","journal-title":"Allergy"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jaci.2006.03.008","article-title":"Which aspects of the farming lifestyle explain the inverse association with childhood allergy?","volume":"117","author":"MR Perkin","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref14","unstructured":"Shropshire Council (2011) Agriculture, forestry and fishing\u2014agricultural land use. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.shropshire.gov.uk\/factsfigures.nsf\/open\/5759F15AE2569308802574720032E09C\" xlink:type=\"simple\">http:\/\/www.shropshire.gov.uk\/factsfigures.nsf\/open\/5759F15AE2569308802574720032E09C<\/ext-link>."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-2222.2000.00801.x","article-title":"Reduced risk of hay fever and asthma among children of farmers","volume":"30","author":"OS Von Ehrenstein","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(01)06252-3","article-title":"Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey","volume":"358","author":"J Riedler","year":"2001","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: effects on childhood asthma and allergy","volume":"10","author":"E von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jaci.2013.07.003","article-title":"Become a farmer and avoid new allergic sensitization: adult farming exposures protect against new-onset atopic sensitization","volume":"132","author":"G Elholm","year":"2013","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 1","key":"ref19","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1136\/thorax.55.suppl_1.S2","article-title":"Family size, infection and atopy: the first decade of the &quot;hygiene hypothesis&quot;","volume":"55","author":"DP Strachan","year":"2000","journal-title":"Thorax"},{"key":"ref20","unstructured":"Shropshire Star (2011 February) Shropshire foot and mouth horror recalled. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.shropshirestar.com\/news\/2011\/02\/19\/shropshire-foot-and-mouth-horror-recalled\/\" xlink:type=\"simple\">http:\/\/www.shropshirestar.com\/news\/2011\/02\/19\/shropshire-foot-and-mouth-horror-recalled\/<\/ext-link>."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:06:04Z","timestamp":1540231564000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143651"}},"subtitle":[],"editor":[{"given":"Luo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,24]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143651","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,24]]}}}