{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:56:51Z","timestamp":1759694211817},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0143922","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T18:45:10Z","timestamp":1449254710000},"page":"e0143922","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Endoplasmic Reticulum Stress in Heat- and Shake-Induced Injury in the Rat Small Intestine"],"prefix":"10.1371","volume":"10","author":[{"given":"Peng","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changrong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1152\/ajpgi.2001.280.1.G7","article-title":"Stress and intestinal barrier function","volume":"280","author":"JD PM S\u00f6derholm","year":"2001","journal-title":"American Journal of Physiology\u2014Gastrointestinal and Liver Physiology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1152\/jappl.1988.64.6.2582","article-title":"Peripheral vascular responses to hyperthermia in the rat","volume":"64","author":"KC Kregel","year":"1988","journal-title":"Journal of applied physiology"},{"issue":"8","key":"ref3","article-title":"Hyperthermia and heatstroke","volume":"29","year":"1994","journal-title":"Hosp Pract (Off Ed)"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"H509","DOI":"10.1152\/ajpheart.2001.280.2.H509","article-title":"Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia","volume":"280","author":"DM Hall","year":"2001","journal-title":"Am J Physiol-Heart C"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3109\/02656736.2010.481276","article-title":"Involvement of ERK12 signalling and growth-related molecules expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells","volume":"26","author":"Jin Yu","year":"2010","journal-title":"International Journal of Hyperthermia"},{"issue":"9","key":"ref6","first-page":"1017","article-title":"The worsening of tissue damage due to the transient release during the ischemia of rat small intestine\u2014the relation with reactive oxygen species and lipid peroxidation","volume":"94","author":"Y KH Moriwaki","year":"1993","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj3130017","article-title":"Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer","volume":"313","author":"H Wiseman","year":"1996","journal-title":"Biochemical Journal"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/10253890.2012.680526","article-title":"Involvement of oxidative stress and mitogen-activated protein kinase signaling pathways in heat stress-induced injury in the rat small intestine","volume":"16","author":"J Yu","year":"2013","journal-title":"Stress"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.rvsc.2014.01.008","article-title":"Effect of simulated transport stress on the rat small intestine: A morphological and gene expression study","volume":"96","author":"C Wan","year":"2014","journal-title":"Research in veterinary science"},{"key":"ref10","unstructured":"Shu B. Transportation stress cause rats\u2019 jejunum injure which associate with oxidative stress and the activation of MAPKs (in chinese). Thesis for Master\u2019s Degree Northwest A&F University 2013;UDC: 636.09"},{"issue":"11","key":"ref11","first-page":"1561","article-title":"Transport stress causes damage in rats' liver and triggers liver autophagy. BioTechnology","volume":"8","author":"Peng Yin","year":"2013","journal-title":"An Indian Journal"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: coping with stress","volume":"14","author":"DT Rutkowski","year":"2004","journal-title":"Trends Cell Biol"},{"issue":"1\u20132","key":"ref13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","article-title":"ER stress and the unfolded protein response","volume":"569","author":"M Schroder","year":"2005","journal-title":"Mutation research"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI0216784","article-title":"Translational control in the endoplasmic reticulum stress response","volume":"110","author":"D Ron","year":"2002","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"ref15","first-page":"33","article-title":"Integration of ER stress, oxidative stress and the inflammatory response in health and disease","volume":"3","author":"K Zhang","year":"2010","journal-title":"International journal of clinical and experimental medicine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1196\/annals.1299.032","article-title":"Caspase-12 and ER-stress-mediated apoptosis: the story so far","volume":"1010","author":"E FU Szegezdi","year":"2003","journal-title":"Ann N Y Acad Sci"},{"issue":"6765","key":"ref17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"T Nakagawa","year":"2000","journal-title":"Nature"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1210\/en.2008-0794","article-title":"The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I","volume":"150","author":"CG Zou","year":"2009","journal-title":"Endocrinology"},{"issue":"40","key":"ref19","doi-asserted-by":"crossref","first-page":"30299","DOI":"10.1074\/jbc.M607007200","article-title":"Endoplasmic reticulum stress triggers autophagy","volume":"281","author":"T Yorimitsu","year":"2006","journal-title":"The Journal of biological chemistry"},{"issue":"24","key":"ref20","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"M Ogata","year":"2006","journal-title":"Molecular and cellular biology"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"E Szegezdi","year":"2006","journal-title":"EMBO reports"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?","volume":"9","author":"JD Malhotra","year":"2007","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2013.11.019","article-title":"p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents","volume":"344","author":"X Sui","year":"2014","journal-title":"Cancer letters"},{"issue":"20","key":"ref24","doi-asserted-by":"crossref","first-page":"15479","DOI":"10.1039\/C4RA13557A","article-title":"Hydrogen peroxide-induced oxidative stress activates NF-[small kappa]B and Nrf2\/Keap1 signals and triggers autophagy in piglets","volume":"5","author":"J Yin","year":"2015","journal-title":"RSC Advances"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"C1200","DOI":"10.1152\/ajpcell.1995.269.5.C1200","article-title":"Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation","volume":"269","author":"AM Cuervo","year":"1995","journal-title":"Am J Physiol"},{"issue":"Pt 1","key":"ref26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1242\/jcs.01620","article-title":"The molecular machinery of autophagy: unanswered questions","volume":"118","author":"DJ Klionsky","year":"2005","journal-title":"J Cell Sci"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1091\/mbc.E08-11-1092","article-title":"Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection","volume":"20","author":"Y Ishida","year":"2009","journal-title":"Molecular biology of the cell"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"DJ Klionsky","year":"2012","journal-title":"Autophagy"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4161\/auto.8.2.18563","article-title":"Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro","volume":"8","author":"Xianghua Yan","year":"2012","journal-title":"Autophagy"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4161\/auto.6.2.11062","article-title":"ER stress negatively regulates AKT\/TSC\/mTOR pathway to enhance autophagy","volume":"6","author":"L Qin","year":"2010","journal-title":"Autophagy"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00726-013-1643-5","article-title":"Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs","volume":"46","author":"J Yin","year":"2014","journal-title":"Amino acids"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"e0122893","DOI":"10.1371\/journal.pone.0122893","article-title":"Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in piglets","volume":"10","author":"J Yin","year":"2015","journal-title":"PloS one"},{"issue":"12","key":"ref33","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3109\/10715762.2013.848277","article-title":"Birth oxidative stress and the development of an antioxidant system in newborn piglets","volume":"47","author":"J Yin","year":"2013","journal-title":"Free radical research"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2527\/jas.2013-6986","article-title":"Development of an antioxidant system after early weaning in piglets","volume":"92","author":"J Yin","year":"2014","journal-title":"Journal of animal science"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cbpa.2010.01.008","article-title":"Effect of heat stress on the porcine small intestine: a morphological and gene expression study","volume":"156","author":"J Yu","year":"2010","journal-title":"Comparative biochemistry and physiology Part A, Molecular & integrative physiology"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1053\/gast.2000.18152","article-title":"Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat","volume":"119","author":"JB Meddings","year":"2000","journal-title":"Gastroenterology"},{"issue":"6","key":"ref37","first-page":"G418","article-title":"Regional susceptibility to stress-induced intestinal injury in the mouse","volume":"305","author":"VL Novosad","year":"2013","journal-title":"Am J Physiol-Gastr L"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI0216886","article-title":"Orchestrating the unfolded protein response in health and disease","volume":"110","author":"RJ Kaufman","year":"2002","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0955-0674(00)00219-2","article-title":"Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals","volume":"13","author":"C Patil","year":"2001","journal-title":"Current Opinion in Cell Biology"},{"issue":"2","key":"ref40","first-page":"132","article-title":"Oxidative stress-mediated signaling pathways: A review","volume":"11","author":"J Yin","year":"2013","journal-title":"J Food Agric Environ"},{"issue":"1\u20132","key":"ref41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1089\/ars.2006.8.152","article-title":"Oxidative stress and autophagy","volume":"8","author":"R Kiffin","year":"2006","journal-title":"Antioxidants & Redox Signaling"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4161\/oxim.3.3.12106","article-title":"Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer","volume":"3","author":"EE Essick","year":"2010","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1423-0127-16-19","article-title":"Ischemic conditioning by short periods of reperfusion attenuates renal ischemia\/reperfusion induced apoptosis and autophagy in the rat","volume":"16","author":"HH Wu","year":"2009","journal-title":"Journal of biomedical science"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes","volume":"4","author":"DJ Klionsky","year":"2008","journal-title":"Autophagy"},{"issue":"7182","key":"ref45","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"N Mizushima","year":"2008","journal-title":"Nature"},{"issue":"5\u20136","key":"ref46","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.mam.2006.08.010","article-title":"Nutrient control of macroautophagy in mammalian cells","volume":"27","author":"M Kadowaki","year":"2006","journal-title":"Molecular aspects of medicine"},{"issue":"14","key":"ref47","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1101\/gad.1799609","article-title":"Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains","volume":"23","author":"N Chalhoub","year":"2009","journal-title":"Genes & Development"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ccr.2005.08.008","article-title":"The Akt-mTOR tango and its relevance to cancer","volume":"8","author":"N Hay","year":"2005","journal-title":"Cancer Cell"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-05-2925","article-title":"mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt","volume":"66","author":"KE O'Reilly","year":"2006","journal-title":"Cancer research"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","article-title":"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB","volume":"22","author":"DD Sarbassov","year":"2006","journal-title":"Molecular cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pathmechdis.3.121806.151434","article-title":"Endoplasmic reticulum stress in disease pathogenesis","volume":"3","author":"JH Lin","year":"2008","journal-title":"Annual review of pathology"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"e39120","DOI":"10.1371\/journal.pone.0039120","article-title":"Endoplasmic reticulum stress stimulates p53 expression through NF-kappaB activation","volume":"7","author":"WC Lin","year":"2012","journal-title":"PloS one"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1083\/jcb.150.4.887","article-title":"Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis","volume":"150","author":"T Nakagawa","year":"2000","journal-title":"J Cell Biol"},{"issue":"11","key":"ref54","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1074\/jbc.M509868200","article-title":"Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53","volume":"281","author":"J Li","year":"2006","journal-title":"The Journal of biological chemistry"},{"issue":"5453","key":"ref55","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"F Urano","year":"2000","journal-title":"Science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0143922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:54:44Z","timestamp":1589014484000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0143922"}},"subtitle":[],"editor":[{"given":"Michael","family":"Muders","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,4]]},"references-count":55,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0143922","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,4]]}}}