{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:33:07Z","timestamp":1781811187796,"version":"3.54.5"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0144145","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T19:19:48Z","timestamp":1449602388000},"page":"e0144145","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5"],"prefix":"10.1371","volume":"10","author":[{"given":"Sini","family":"Kinnunen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"V\u00e4lim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja","family":"T\u00f6lli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Wohlfahrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Darwich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Komati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Nemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Ruskoaho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,7]]},"reference":[{"issue":"50","key":"ref1","doi-asserted-by":"crossref","first-page":"38949","DOI":"10.1074\/jbc.R000029200","article-title":"The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression","volume":"275","author":"JD Molkentin","year":"2000","journal-title":"J.Biol.Chem."},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cardiores.2004.03.025","article-title":"GATA transcription factors in the developing and adult heart","volume":"63","author":"S Pikkarainen","year":"2004","journal-title":"Cardiovasc.Res."},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0959-437X(02)00319-2","article-title":"The GATA family (vertebrates and invertebrates)","volume":"12","author":"RK Patient","year":"2002","journal-title":"Curr.Opin.Genet.Dev."},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/dbio.1994.1206","article-title":"Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development","volume":"164","author":"M Heikinheimo","year":"1994","journal-title":"Dev.Biol."},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation","volume":"11","author":"CT Kuo","year":"1997","journal-title":"Genes Dev"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","article-title":"Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis","volume":"11","author":"JD Molkentin","year":"1997","journal-title":"Genes Dev"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1242\/dev.124.12.2387","article-title":"Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor","volume":"124","author":"C Grepin","year":"1997","journal-title":"Development"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1128\/MCB.00218-12","article-title":"Dissociation of cardiogenic and postnatal myocardial activities of GATA4","volume":"32","author":"JM Gallagher","year":"2012","journal-title":"Mol.Cell.Biol."},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"M Ieda","year":"2010","journal-title":"Cell"},{"issue":"7247","key":"ref10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nature08039","article-title":"Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors","volume":"459","author":"JK Takeuchi","year":"2009","journal-title":"Nature"},{"issue":"7288","key":"ref11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","article-title":"Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes","volume":"464","author":"K Kikuchi","year":"2010","journal-title":"Nature"},{"issue":"13","key":"ref12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cub.2013.05.028","article-title":"An injury-responsive gata4 program shapes the zebrafish cardiac ventricle","volume":"23","author":"V Gupta","year":"2013","journal-title":"Curr.Biol."},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1128\/MCB.14.5.3115","article-title":"A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription","volume":"14","author":"C Grepin","year":"1994","journal-title":"Mol.Cell.Biol."},{"issue":"18","key":"ref14","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1093\/emboj\/16.18.5687","article-title":"The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors","volume":"16","author":"D Durocher","year":"1997","journal-title":"EMBO J"},{"issue":"18","key":"ref15","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1073\/pnas.0401833101","article-title":"Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity","volume":"101","author":"A Aries","year":"2004","journal-title":"Proc.Natl.Acad.Sci.U.S.A."},{"issue":"39","key":"ref16","doi-asserted-by":"crossref","first-page":"14471","DOI":"10.1073\/pnas.0602543103","article-title":"Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure","volume":"103","author":"E Bisping","year":"2006","journal-title":"Proc.Natl.Acad.Sci.U.S.A."},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/01.CIR.103.5.730","article-title":"Pressure overload increases GATA4 binding activity via endothelin-1","volume":"103","author":"N Hautala","year":"2001","journal-title":"Circulation"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1172\/JCI32573","article-title":"Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart","volume":"117","author":"J Heineke","year":"2007","journal-title":"J.Clin.Invest."},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000215985.18538.c4","article-title":"Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability","volume":"98","author":"T Oka","year":"2006","journal-title":"Circ.Res."},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1161\/CIRCHEARTFAILURE.109.889642","article-title":"GATA-4 is an angiogenic survival factor of the infarcted heart","volume":"3","author":"J Rysa","year":"2010","journal-title":"Circ.Heart Fail."},{"issue":"23","key":"ref21","doi-asserted-by":"crossref","first-page":"24852","DOI":"10.1074\/jbc.M314317200","article-title":"Mitogen-activated protein kinases p38 and ERK 1\/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart","volume":"279","author":"O Tenhunen","year":"2004","journal-title":"J.Biol.Chem."},{"issue":"20","key":"ref22","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1101\/gad.915701","article-title":"Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA","volume":"15","author":"F Charron","year":"2001","journal-title":"Genes Dev"},{"issue":"13","key":"ref23","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1101\/gad.9.13.1654","article-title":"Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5","volume":"9","author":"I Lyons","year":"1995","journal-title":"Genes Dev"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/humu.21345","article-title":"NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD)","volume":"31","author":"SM Reamon-Buettner","year":"2010","journal-title":"Hum.Mutat."},{"issue":"5373","key":"ref25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.281.5373.108","article-title":"Congenital heart disease caused by mutations in the transcription factor NKX2-5","volume":"281","author":"JJ Schott","year":"1998","journal-title":"Science"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1128\/MCB.19.10.7096","article-title":"Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx\/Nkx-2.5 and GATA-4","volume":"19","author":"K Monzen","year":"1999","journal-title":"Mol.Cell.Biol."},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2007.01.042","article-title":"An Nkx2-5\/Bmp2\/Smad1 negative feedback loop controls heart progenitor specification and proliferation","volume":"128","author":"OW Prall","year":"2007","journal-title":"Cell"},{"issue":"19","key":"ref28","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1242\/dev.126.19.4223","article-title":"Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis","volume":"126","author":"H Kuo","year":"1999","journal-title":"Development"},{"issue":"20","key":"ref29","doi-asserted-by":"crossref","first-page":"14204","DOI":"10.1074\/jbc.274.20.14204","article-title":"Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5","volume":"274","author":"SA Rivkees","year":"1999","journal-title":"J.Biol.Chem."},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/me.2002-0348","article-title":"The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors","volume":"17","author":"M Dentice","year":"2003","journal-title":"Mol.Endocrinol."},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1128\/MCB.18.6.3405","article-title":"GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression","volume":"18","author":"JL Sepulveda","year":"1998","journal-title":"Mol.Cell.Biol."},{"issue":"21","key":"ref32","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1038\/sj.emboj.7601379","article-title":"The Kruppel-like transcription factor KLF13 is a novel regulator of heart development","volume":"25","author":"G Lavallee","year":"2006","journal-title":"EMBO J"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1128\/MCB.13.4.2235","article-title":"Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart","volume":"13","author":"RJ Arceci","year":"1993","journal-title":"Mol.Cell.Biol."},{"issue":"16","key":"ref34","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/dev.125.16.3037","article-title":"Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice","volume":"125","author":"G Ranganayakulu","year":"1998","journal-title":"Development"},{"issue":"26","key":"ref35","doi-asserted-by":"crossref","first-page":"15628","DOI":"10.1074\/jbc.270.26.15628","article-title":"Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5","volume":"270","author":"CY Chen","year":"1995","journal-title":"J.Biol.Chem."},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1124\/jpet.102.041582","article-title":"Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells","volume":"304","author":"J Hakkola","year":"2003","journal-title":"J.Pharmacol.Exp.Ther."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6750-4-10","article-title":"Activation of the control reporter plasmids pRL-TK and pRL-SV40 by multiple GATA transcription factors can lead to aberrant normalization of transfection efficiency","volume":"4","author":"CK Ho","year":"2004","journal-title":"BMC Biotechnol"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/MCB.14.1.777","article-title":"Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells","volume":"14","author":"S Argentin","year":"1994","journal-title":"Mol.Cell.Biol."},{"issue":"26","key":"ref39","doi-asserted-by":"crossref","first-page":"23807","DOI":"10.1074\/jbc.M302719200","article-title":"GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program","volume":"278","author":"S Pikkarainen","year":"2003","journal-title":"J.Biol.Chem."},{"issue":"16","key":"ref40","doi-asserted-by":"crossref","first-page":"13752","DOI":"10.1074\/jbc.M105736200","article-title":"Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene","volume":"277","author":"R Kerkel\u00e4","year":"2002","journal-title":"J.Biol.Chem."},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/jcc.20933","article-title":"The generalized Born\/volume integral implicit solvent model: estimation of the free energy of hydration using London dispersion instead of atomic surface area","volume":"29","author":"P Labute","year":"2008","journal-title":"J.Comput.Chem."},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by Calpha geometry: phi,psi and Cbeta deviation","volume":"50","author":"SC Lovell","year":"2003","journal-title":"Proteins"},{"issue":"34","key":"ref43","doi-asserted-by":"crossref","first-page":"24915","DOI":"10.1074\/jbc.M701789200","article-title":"Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles","volume":"282","author":"AS Philips","year":"2007","journal-title":"J.Biol.Chem."},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/EC.00040-14","article-title":"Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA","volume":"13","author":"CC Hunter","year":"2014","journal-title":"Eukaryot.Cell."},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1136\/jmg.2004.025395","article-title":"GATA4 zinc finger mutations as a molecular rationale for septation defects of the human heart.[Report]","volume":"42","author":"SM Reamon-Buettner","year":"2005","journal-title":"J.Med.Genet."},{"issue":"7","key":"ref46","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1101\/gad.875201","article-title":"Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors","volume":"15","author":"JD Crispino","year":"2001","journal-title":"Genes Dev"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1128\/MCB.16.5.2238","article-title":"A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction","volume":"16","author":"CD Trainor","year":"1996","journal-title":"Mol.Cell.Biol."},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/(SICI)1520-6408(1998)22:3<250::AID-DVG7>3.0.CO;2-5","article-title":"Combinatorial interactions regulating cardiac transcription","volume":"22","author":"D Durocher","year":"1998","journal-title":"Dev.Genet."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"N Frey","year":"2003","journal-title":"Annu.Rev.Physiol."},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1128\/MCB.18.6.3120","article-title":"The cardiac tissue-restricted homeobox protein Csx\/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression","volume":"18","author":"Y Lee","year":"1998","journal-title":"Mol.Cell.Biol."},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0092-8674(93)90390-C","article-title":"The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements","volume":"75","author":"JW Schwabe","year":"1993","journal-title":"Cell"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1074\/jbc.M004995200","article-title":"Characterization of homo- and heterodimerization of cardiac Csx\/Nkx2.5 homeoprotein","volume":"276","author":"H Kasahara","year":"2001","journal-title":"J.Biol.Chem."},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"e1002690","DOI":"10.1371\/journal.pgen.1002690","article-title":"Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo","volume":"8","author":"C Misra","year":"2012","journal-title":"PLoS Genet"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ydbio.2004.08.008","article-title":"GATA4 is a dosage-sensitive regulator of cardiac morphogenesis","volume":"275","author":"WT Pu","year":"2004","journal-title":"Dev.Biol."},{"issue":"6947","key":"ref55","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature01827","article-title":"GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5","volume":"424","author":"V Garg","year":"2003","journal-title":"Nature"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/humu.9410","article-title":"A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot","volume":"27","author":"G Nemer","year":"2006","journal-title":"Hum.Mutat."},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbrc.2013.09.023","article-title":"GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy","volume":"439","author":"RG Li","year":"2013","journal-title":"Biochem.Biophys.Res.Commun."},{"issue":"12","key":"ref58","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/humu.22434","article-title":"GATA4 loss-of-function mutations underlie familial tetralogy of fallot","volume":"34","author":"YQ Yang","year":"2013","journal-title":"Hum.Mutat."},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1073\/pnas.1312993111","article-title":"Cyclin D2 is a GATA4 cofactor in cardiogenesis","volume":"111","author":"A Yamak","year":"2014","journal-title":"Proc.Natl.Acad.Sci.U.S.A."},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"e62138","DOI":"10.1371\/journal.pone.0062138","article-title":"Identification of functional mutations in GATA4 in patients with congenital heart disease","volume":"8","author":"E Wang","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1073\/pnas.1010257108","article-title":"Loss-of-function mutation in GATA4 causes anomalies of human testicular development","volume":"108","author":"D Lourenco","year":"2011","journal-title":"Proc.Natl.Acad.Sci.U.S.A."},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0092-8674(00)81573-1","article-title":"A calcineurin-dependent transcriptional pathway for cardiac hypertrophy","volume":"93","author":"JD Molkentin","year":"1998","journal-title":"Cell"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"10659","DOI":"10.1074\/jbc.M301648200","article-title":"The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1\/4 via a novel upstream enhancer","volume":"279","author":"CO Brown 3rd","year":"2004","journal-title":"J.Biol.Chem."},{"issue":"22","key":"ref64","doi-asserted-by":"crossref","first-page":"9829","DOI":"10.1128\/MCB.25.22.9829-9844.2005","article-title":"Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4","volume":"25","author":"J Wang","year":"2005","journal-title":"Mol.Cell.Biol."},{"issue":"4","key":"ref65","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/prot.21396","article-title":"Hot spots\u2014a review of the protein-protein interface determinant amino-acid residues","volume":"68","author":"IS Moreira","year":"2007","journal-title":"Proteins"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.gene.2013.10.028","article-title":"A novel mutation of GATA4 (K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis","volume":"534","author":"R Xiang","year":"2014","journal-title":"Gene"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cardiores.2004.06.004","article-title":"Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies","volume":"64","author":"H Kasahara","year":"2004","journal-title":"Cardiovasc.Res."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0144145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T14:56:49Z","timestamp":1653749809000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0144145"}},"subtitle":[],"editor":[{"given":"Enzo","family":"Porrello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,7]]},"references-count":67,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0144145","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,7]]}}}