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Causes of Observed Changes in Extremes and Projections of Future Changes in Weather and Climate Extremes in a Changing Climate. Regions of Focus: North America, Hawaii, Caribbean, and U.S. Pacific Islands. T.R. Karl, G.A. Meehl, C.D. Miller, S.J. Hassol, A.M. Waple, and W.L. Murray (eds.). A Report by the U.S. Climate Change Science Program and the Subcommittee on Global Change Research, Washington, DC. 2008."},{"key":"ref6","unstructured":"Climate Communication | Heat Waves: The Details [Internet]. [cited 20 Aug 2014]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.climatecommunication.org\/new\/articles\/heat-waves-and-climate-change\/heat-waves-the-details\/\" xlink:type=\"simple\">http:\/\/www.climatecommunication.org\/new\/articles\/heat-waves-and-climate-change\/heat-waves-the-details\/<\/ext-link>."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1175\/JCLI-D-12-00383.1","article-title":"On the Measurement of Heat Waves","volume":"26","author":"SE Perkins","year":"2013","journal-title":"J Clim"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2105\/AJPH.2007.119362","article-title":"Climate Change: The Public Health Response","volume":"98","author":"H Frumkin","year":"2008","journal-title":"Am J Public Health"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(09)60935-1","article-title":"Managing the health effects of climate change: Lancet and University College London Institute for Global Health Commission","volume":"373","author":"A Costello","year":"2009","journal-title":"Lancet"},{"key":"ref10","unstructured":"National Climatic Data Center\u2014td3200.pdf [Internet]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www1.ncdc.noaa.gov\/pub\/data\/documentlibrary\/tddoc\/td3200.pdf\" xlink:type=\"simple\">http:\/\/www1.ncdc.noaa.gov\/pub\/data\/documentlibrary\/tddoc\/td3200.pdf<\/ext-link>."},{"key":"ref11","first-page":"1","article-title":"NCHS urban-rural classification scheme for counties","volume":"2","author":"DD Ingram","year":"2012","journal-title":"Vital Health Stat"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/jech.50.3.252","article-title":"Urbanisation and coronary heart disease mortality among African Americans in the US South","volume":"50","author":"E Barnett","year":"1996","journal-title":"J Epidemiol Community Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0895-4356(89)90099-1","article-title":"Regional and urbanization differentials in coronary heart disease mortality in the United States, 1968\u20131985","volume":"42","author":"DD Ingram","year":"1989","journal-title":"J Clin Epidemiol"},{"key":"ref14","first-page":"137","article-title":"Hypertensive Heart Disease Mortality in Wisconsin, 1979\u20132004","volume":"106","author":"L Knobeloch","year":"2007","journal-title":"WMJ-MADISON"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.annepidem.2011.03.003","article-title":"The Epidemiology of Hospitalized Postpartum Depression in New York State, 1995\u20132004","volume":"21","author":"DA Savitz","year":"2011","journal-title":"Ann Epidemiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s10995-013-1307-9","article-title":"Descriptive Epidemiology of Chronic Hypertension, Gestational Hypertension, and Preeclampsia in New York State, 1995\u20132004","volume":"18","author":"DA Savitz","year":"2014","journal-title":"Matern Child Health J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.amepre.2013.07.012","article-title":"Trends and Geographic Patterns in Drug-Poisoning Death Rates in the U.S., 1999\u20132009","volume":"45","author":"LM Rossen","year":"2013","journal-title":"Am J Prev Med"},{"key":"ref18","unstructured":"Data Access\u2014Urban Rural Classification Scheme for Counties [Internet]. [cited 25 Jun 2014]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/nchs\/data_access\/urban_rural.htm\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/nchs\/data_access\/urban_rural.htm<\/ext-link>."},{"key":"ref19","unstructured":"Climate Prediction Center\u2014El Nino Southern Oscillation: Cold and Warm Episodes by Seasons [Internet]. [cited 29 Oct 2013]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cpc.ncep.noaa.gov\/products\/analysis_monitoring\/ensostuff\/ensoyears.shtml\" xlink:type=\"simple\">http:\/\/www.cpc.ncep.noaa.gov\/products\/analysis_monitoring\/ensostuff\/ensoyears.shtml<\/ext-link>."},{"key":"ref20","article-title":"Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change, 2007 [Internet]","author":"S Solomon","year":"2007"},{"key":"ref21","first-page":"1","article-title":"Encycl Res Des","author":"H Abdi","year":"2010"},{"key":"ref22","unstructured":"Greene WH. Accounting for Excess Zeros and Sample Selection in Poisson and Negative Binomial Regression Models [Internet]. Rochester, NY: Social Science Research Network; 1994 Mar. Report No.: ID 1293115. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/papers.ssrn.com\/abstract=1293115\" xlink:type=\"simple\">http:\/\/papers.ssrn.com\/abstract=1293115<\/ext-link>."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0895-4356(03)00028-3","article-title":"Application of negative binomial modeling for discrete outcomes: A case study in aging research","volume":"56","author":"AL Byers","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"ref24","first-page":"1","article-title":"Linkage of the National Health Interview Survey to air quality data","volume":"2","author":"JD Parker","year":"2008","journal-title":"Vital Health Stat"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1289\/ehp.11497","article-title":"Air pollution and childhood respiratory allergies in the United States","volume":"117","author":"JD Parker","year":"2009","journal-title":"Environ Health Perspect"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.envres.2010.01.001","article-title":"The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001\u20132004","volume":"110","author":"LJ Akinbami","year":"2010","journal-title":"Environ Res"},{"key":"ref27","article-title":"Change in Extreme Temperature and Precipitation over Northern China During the Second Half of the20th Century","volume":"58","author":"P Zhai","year":"2003","journal-title":"Acta Geogr Sin"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"D05109","DOI":"10.1029\/2005JD006290","article-title":"Global observed changes in daily climate extremes of temperature and precipitation","volume":"111","author":"LV Alexander","year":"2006","journal-title":"J Geophys Res Atmospheres"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"L07707","DOI":"10.1029\/2008GL037119","article-title":"Trends in joint quantiles of temperature and precipitation in Europe since 1901 and projected for 2100","volume":"36","author":"M Beniston","year":"2009","journal-title":"Geophys Res Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"034014","DOI":"10.1088\/1748-9326\/8\/3\/034014","article-title":"Changes in concurrent monthly precipitation and temperature extremes","volume":"8","author":"Z Hao","year":"2013","journal-title":"Environ Res Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1126\/science.1132588","article-title":"ENSO as an Integrating Concept in Earth Science","volume":"314","author":"MJ McPhaden","year":"2006","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1126\/science.1071281","article-title":"Ecological Effects of Climate Fluctuations","volume":"297","author":"NC Stenseth","year":"2002","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1098\/rspb.2003.2415","article-title":"Studying climate effects on ecology through the use of climate indices: the North Atlantic Oscillation, El Nino Southern Oscillation and beyond","volume":"270","author":"NC Stenseth","year":"2003","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1126\/science.1203724","article-title":"Reduced Interannual Rainfall Variability in East Africa During the Last Ice Age","volume":"333","author":"C Wolff","year":"2011","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1175\/1520-0442(1999)012<3255:STCEOT>2.0.CO;2","article-title":"Short-Term Climate Extremes over the Continental United States and ENSO. 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Lett"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature04188","article-title":"Impact of regional climate change on human health","volume":"438","author":"JA Patz","year":"2005","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cosust.2009.07.004","article-title":"Regional Earth System prediction: a decision-making tool for sustainability?","volume":"1","author":"R Murtugudde","year":"2009","journal-title":"Curr Opin Environ Sustain"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.amepre.2008.08.021","article-title":"Climate Change and Extreme Heat Events","volume":"35","author":"G Luber","year":"2008","journal-title":"Am J Prev Med"},{"key":"ref42","article-title":"A multi-city analysis of the UHI-influence on warm season rainfall","author":"M Ganeshan","journal-title":"Urban Clim"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature01675","article-title":"Impact of urbanization and land-use change on climate","volume":"423","author":"E Kalnay","year":"2003","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9540","DOI":"10.1073\/pnas.0400357101","article-title":"Evidence for a significant urbanization effect on climate in China","volume":"101","author":"L Zhou","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1126\/science.1128834","article-title":"Warming and earlier spring increase western US forest wildfire activity","volume":"313","author":"AL Westerling","year":"2006","journal-title":"Science"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jaci.2011.10.032","article-title":"Anthropogenic climate change and allergen exposure: the role of plant biology","volume":"129","author":"LH Ziska","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/17709","article-title":"Growing season extended in Europe","volume":"397","author":"A Menzel","year":"1999","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1175\/1520-0477(2001)082<0399:CITOOS>2.3.CO;2","article-title":"Changes in the onset of spring in the western United States","volume":"82","author":"DR Cayan","year":"2001","journal-title":"Bull Am Meteorol Soc"},{"key":"ref49","doi-asserted-by":"crossref","DOI":"10.1029\/2005GL022911","article-title":"Potential regional climate change and implications to US air quality","volume":"32","author":"LR Leung","year":"2005","journal-title":"Geophys Res Lett"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.envint.2015.06.006","article-title":"Climate change, extreme events and increased risk of salmonellosis in Maryland, USA: Evidence for coastal vulnerability","volume":"83","author":"C Jiang","year":"2015","journal-title":"Environ Int"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1126\/science.289.5487.2068","article-title":"Climate extremes: observations, modeling, and impacts","volume":"289","author":"DR Easterling","year":"2000","journal-title":"science"},{"key":"ref52","author":"JJ McCarthy","year":"2001"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0144202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T12:42:59Z","timestamp":1540039379000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0144202"}},"subtitle":[],"editor":[{"given":"Kristie 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