{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:05:33Z","timestamp":1778688333469,"version":"3.51.4"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0144507","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T18:41:45Z","timestamp":1449772905000},"page":"e0144507","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Toxoplasma gondii Chitinase Induces Macrophage Activation"],"prefix":"10.1371","volume":"10","author":[{"given":"Fausto","family":"Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Sardinha-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Aparecido","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Moreira","family":"Pessoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Figueiredo","family":"Pinzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Claudia Paiva","family":"Alegre-Maller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerry Tatiana","family":"Cec\u00edlio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilmar Silvio","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Ricardo Lima","family":"Dam\u00e1sio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wellington Ramos","family":"Pedersoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Roberto","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Nascimento","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Roque-Barreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"issue":"12\u201313","key":"ref1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"AM Tenter","year":"2000","journal-title":"International journal for parasitology"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.clp.2005.04.011","article-title":"Diagnosis and management of toxoplasmosis","volume":"32","author":"JG Montoya","year":"2005","journal-title":"Clinics in perinatology"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00321-12","article-title":"Integrated Bioinformatic and Targeted Deletion Analyses of the SRS Gene Superfamily Identify SRS29C as a Negative Regulator of Toxoplasma Virulence","volume":"3","author":"JD Wasmuth","year":"2012","journal-title":"Mbio"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"e02280","DOI":"10.1128\/mBio.02280-14","article-title":"Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5\/ROP18 allelic combination","volume":"6","author":"KD Jensen","year":"2015","journal-title":"Mbio"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpara.2003.12.004","article-title":"The SRS superfamily of Toxoplasma surface proteins","volume":"34","author":"C Jung","year":"2004","journal-title":"International journal for parasitology"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/infdis\/159.4.790","article-title":"Differences in Virulence and Development of Encephalitis during Chronic Infection Vary with the Strain of Toxoplasma-Gondii","volume":"159","author":"Y Suzuki","year":"1989","journal-title":"Journal of Infectious Diseases"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/clinids\/15.2.211","article-title":"Toxoplasmic encephalitis in AIDS","volume":"15","author":"BJ Luft","year":"1992","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1086\/322800","article-title":"Unusual abundance of atypical strains associated with human ocular toxoplasmosis","volume":"184","author":"ME Grigg","year":"2001","journal-title":"The Journal of infectious diseases"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.ajo.2015.02.015","article-title":"Ocular Involvement Following Postnatally Acquired Toxoplasma gondii Infection in Southern Brazil: A 28-Year Experience","volume":"159","author":"TE Arantes","year":"2015","journal-title":"American journal of ophthalmology"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/glycob\/cwv005","article-title":"Keeping track of the growing number of biological functions of chitin and its interaction partners in biomedical research","volume":"25","author":"BE Koch","year":"2015","journal-title":"Glycobiology"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11046-006-0024-y","article-title":"Review of fungal chitinases","volume":"161","author":"L Duo-Chuan","year":"2006","journal-title":"Mycopathologia"},{"issue":"20","key":"ref12","doi-asserted-by":"crossref","first-page":"9944","DOI":"10.1073\/pnas.89.20.9944","article-title":"Leishmania infections damage the feeding mechanism of the sandfly vector and implement parasite transmission by bite","volume":"89","author":"Y Schlein","year":"1992","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1073\/pnas.90.9.4266","article-title":"Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease","volume":"90","author":"M Shahabuddin","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref14","first-page":"223","article-title":"Chitinases of human parasites and their implications as antiparasitic targets","volume":"87","author":"M Shahabuddin","year":"1999","journal-title":"Exs"},{"issue":"1359","key":"ref15","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1098\/rstb.1997.0119","article-title":"Genetic and biochemical analysis of development in Toxoplasma gondii","volume":"352","author":"JC Boothroyd","year":"1997","journal-title":"Philosophical transactions of the Royal Society of London Series B, Biological sciences"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2307\/3280662","article-title":"Identification of the structural component in the cyst wall of Entamoeba invadens","volume":"66","author":"A Arroyo-Begovich","year":"1980","journal-title":"The Journal of parasitology"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/IAI.49.3.629-634.1985","article-title":"Identification of Chitin as a Structural Component of Giardia Cysts","volume":"49","author":"HD Ward","year":"1985","journal-title":"Infection and immunity"},{"issue":"3\u20134","key":"ref18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0300-9084(03)00076-2","article-title":"Developmentally regulated biosynthesis of carbohydrate and storage polysaccharide during differentiation and tissue cyst formation in Toxoplasma gondii","volume":"85","author":"A Coppin","year":"2003","journal-title":"Biochimie"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"e1002990","DOI":"10.1371\/journal.ppat.1002990","article-title":"Chitinase dependent control of protozoan cyst burden in the brain","volume":"8","author":"JP Nance","year":"2012","journal-title":"PLoS pathogens"},{"issue":"7140","key":"ref20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature05746","article-title":"Chitin induces accumulation in tissue of innate immune cells associated with allergy","volume":"447","author":"TA Reese","year":"2007","journal-title":"Nature"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/yea.1731","article-title":"Paracoccin from Paracoccidioides brasiliensis; purification through affinity with chitin and identification of N-acetyl-beta-D-glucosaminidase activity","volume":"27","author":"FB dos Reis Almeida","year":"2010","journal-title":"Yeast"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"e29216","DOI":"10.1371\/journal.pone.0029216","article-title":"Influence of N-glycosylation on the morphogenesis and growth of Paracoccidioides brasiliensis and on the biological activities of yeast proteins","volume":"6","author":"FB Dos Reis Almeida","year":"2011","journal-title":"Plos One"},{"issue":"20","key":"ref23","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"A Keller","year":"2002","journal-title":"Anal Chem"},{"issue":"17","key":"ref24","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"AI Nesvizhskii","year":"2003","journal-title":"Anal Chem"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"A Roy","year":"2010","journal-title":"Nature protocols"},{"issue":"D1","key":"ref26","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkt1223","article-title":"Pfam: the protein families database","volume":"42","author":"RD Finn","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"LA Kelley","year":"2015","journal-title":"Nature protocols"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1128\/JB.182.7.1916-1922.2000","article-title":"Purification and characterization of the DeoR repressor of Bacillus subtilis","volume":"182","author":"X Zeng","year":"2000","journal-title":"Journal of bacteriology"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08820137509055757","article-title":"Antigenic and Enzymatic Changes in Infected and Transformed Human Diploid Cells","volume":"4","author":"NR Rose","year":"1975","journal-title":"Immunol Commun"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/expr.1996.0063","article-title":"Purification and characterization of N-acetylglucosaminidase from Trypanosoma cruzi","volume":"83","author":"B ElMoudni","year":"1996","journal-title":"Experimental Parasitology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-physiol-012110-142250","article-title":"Role of chitin and chitinase\/chitinase-like proteins in inflammation, tissue remodeling, and injury","volume":"73","author":"CG Lee","year":"2011","journal-title":"Annual review of physiology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1297-9716-42-80","article-title":"Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1beta secretion enhances parasite replication","volume":"42","author":"ES Marshall","year":"2011","journal-title":"Veterinary research"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/IAI.62.7.2818-2824.1994","article-title":"Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha","volume":"62","author":"CA Hunter","year":"1994","journal-title":"Infection and immunity"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.4049\/jimmunol.157.9.4045","article-title":"In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection","volume":"157","author":"TM SchartonKersten","year":"1996","journal-title":"J Immunol"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S1471-4922(02)02248-1","article-title":"Toxoplasma gondii tachyzoite-bradyzoite interconversion","volume":"18","author":"RE Lyons","year":"2002","journal-title":"Trends in parasitology"},{"key":"ref36","article-title":"Virulence-associated enzymes of Cryptococcus neoformans","author":"F Almeida","year":"2015","journal-title":"Eukaryotic cell"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/IAI.21.1.55-58.1978","article-title":"Immunoglobulin G and immunoglobulin M enzyme-linked immunosorbent assays and defined toxoplasmosis serological patterns","volume":"21","author":"ME Camargo","year":"1978","journal-title":"Infection and immunity"},{"key":"ref38","article-title":"Vaccination with Recombinant Microneme Proteins Confers Protection against Experimental Toxoplasmosis in Mice","author":"CFS-S Pinzan","year":"2015","journal-title":"Plos One"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/glycob\/11.7.541","article-title":"Toxoplasma gondii micronemal protein MIC1 is a lactose-binding lectin","volume":"11","author":"EV Lourenco","year":"2001","journal-title":"Glycobiology"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2323\/jgam.32.25","article-title":"Purification and Characterization of Chitinase and Chitobiase Produced by Aeromonas-Hydrophila Subsp Anaerogenes-A52","volume":"32","author":"M Yabuki","year":"1986","journal-title":"J Gen Appl Microbiol"},{"issue":"5259","key":"ref41","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"UK Laemmli","year":"1970","journal-title":"Nature"},{"key":"ref42","article-title":"Comparative metabolism of cellulose, sophorose and glucose in Trichoderma reesei using high-throughput genomic and proteomic analyses","volume":"7","author":"LDS Castro","year":"2014","journal-title":"Biotechnol Biofuels"},{"issue":"22","key":"ref43","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1093\/bioinformatics\/btl379","article-title":"General framework for developing and evaluating database scoring algorithms using the TANDEM search engine","volume":"22","author":"B MacLean","year":"2006","journal-title":"Bioinformatics"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/yea.2983","article-title":"alpha-(1,4)-Amylase, but not alpha- and beta-(1,3)-glucanases, may be responsible for the impaired growth and morphogenesis of Paracoccidioides brasiliensis induced by N-glycosylation inhibition","volume":"31","author":"Almeida FB Dos Reis","year":"2014","journal-title":"Yeast"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2672.2010.04879.x","article-title":"Purification and characterization of an exo-type beta-N-acetylglucosaminidase from Pseudomonas fluorescens JK-0412","volume":"110","author":"JK Park","year":"2011","journal-title":"Journal of Applied Microbiology"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00253-002-1129-y","article-title":"A novel beta-N-acetylglucosaminidase of Clostridium paraputrificum M-21 with high activity on chitobiose","volume":"60","author":"H Li","year":"2002","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00253-003-1490-5","article-title":"Purification and characterization of an N-acetylglucosaminidase produced by a Trichoderma harzianum strain which controls Crinipellis perniciosa","volume":"64","author":"JL De Marco","year":"2004","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"17","key":"ref48","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s10529-005-0218-2","article-title":"Purification and properties of an N-acetylglucosaminidase from Streptomyces cerradoensis","volume":"27","author":"IDJ Sobrinho","year":"2005","journal-title":"Biotechnology Letters"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0144507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T03:35:45Z","timestamp":1692156945000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0144507"}},"subtitle":[],"editor":[{"given":"Vijai","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,10]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0144507","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,10]]}}}