{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:08:54Z","timestamp":1787616534999,"version":"build-2736575974"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T00:00:00Z","timestamp":1449792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0144541","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T18:42:30Z","timestamp":1449859350000},"page":"e0144541","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways"],"prefix":"10.1371","volume":"10","author":[{"given":"Manisha","family":"Dixit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Raghuvanshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Prakash","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Kureel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Nizam","family":"Mansoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijaz A.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipak","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Awasthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1741-7015-9-66","article-title":"Bone regeneration: current concepts and future directions","volume":"9","author":"R Dimitriou","year":"2011","journal-title":"BMC Med"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1517\/13543784.2012.696610","article-title":"Drugs for bone healing","volume":"21","author":"ML Brandi","year":"2012","journal-title":"Expert Opin Investig Drugs"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.injury.2011.03.031","article-title":"The biology of fracture healing","volume":"42","author":"R Marsell","year":"2011","journal-title":"Injury"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bone.2009.09.007","article-title":"Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing","volume":"46","author":"L Monfoulet","year":"2010","journal-title":"Bone"},{"issue":"6","key":"ref5","first-page":"1400","article-title":"Bone regeneration in osteoporotic conditions: healing of subcritical-size calvarial defects in the ovariectomized rat","volume":"27","author":"SF Durao","year":"2012","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1749-799X-9-18","article-title":"Bone regenerative medicine: classic options, novel strategies, and future directions","volume":"9","author":"A Oryan","year":"2014","journal-title":"Journal of orthopaedic surgery and research"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bone.2010.08.016","article-title":"Deficiency of vitamin A delays bone healing process in association with reduced BMP2 expression after drill-hole injury in mice","volume":"47","author":"K Tanaka","year":"2010","journal-title":"Bone"},{"issue":"9\u201310","key":"ref8","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1089\/ten.tea.2010.0555","article-title":"High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo","volume":"17","author":"JN Zara","year":"2011","journal-title":"Tissue engineering Part A"},{"issue":"21\u201322","key":"ref9","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1089\/ten.tea.2012.0519","article-title":"BMP2-induced inflammation can be suppressed by the osteoinductive growth factor NELL-1","volume":"19","author":"J Shen","year":"2013","journal-title":"Tissue engineering Part A"},{"issue":"30","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta11300","article-title":"Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review","volume":"11","author":"KR Garrison","year":"2007","journal-title":"Health Technol Assess"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1359\/jbmr.070724","article-title":"Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures","volume":"22","author":"S Kakar","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"ref12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2106\/JBJS.G.01443","article-title":"Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment","volume":"90","author":"GL Barnes","year":"2008","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bone.2008.11.007","article-title":"Recombinant human parathyroid hormone (PTH 1\u201334) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing","volume":"44","author":"SJ Warden","year":"2009","journal-title":"Bone"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/IJWH.S4919","article-title":"Profile of teriparatide in the management of postmenopausal osteoporosis","volume":"2","author":"A Sikon","year":"2010","journal-title":"Int J Womens Health"},{"key":"ref15","first-page":"193","article-title":"Update on the efficacy, safety, and adherence to treatment of full length parathyroid hormone, PTH (1\u201384), in the treatment of postmenopausal osteoporosis","volume":"1","author":"L Pietrogrande","year":"2010","journal-title":"Int J Womens Health"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1021\/cr300219y","article-title":"Synthesis, stereochemistry, structural classification, and chemical reactivity of natural pterocarpans","volume":"113","author":"A Goel","year":"2012","journal-title":"Chem Rev"},{"key":"ref17","unstructured":"Goel A KA, Chaurasia S, Singh D, Gautam AK, Pandey R, Trivedi R, Singh MM, Chattopadhyay N, Manawickasagam L, Jain GK, Dwivedi AK. Substituted benzofurochromenes and related compounds for the prevention and treatment of bone related disorders. 2014;Patent Appl. US8686028"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bmcl.2008.12.064","article-title":"Osteogenic activity of constituents from Butea monosperma","volume":"19","author":"R Maurya","year":"2009","journal-title":"Bioorganic & medicinal chemistry letters"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jnutbio.2010.11.002","article-title":"Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor beta-mediated osteogenic action of medicarpin","volume":"23","author":"B Bhargavan","year":"2012","journal-title":"J Nutr Biochem"},{"issue":"1\u20132","key":"ref20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mce.2010.05.016","article-title":"Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice","volume":"325","author":"AM Tyagi","year":"2010","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/gme.0b013e3181d0f7f0","article-title":"Total extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fraction","volume":"17","author":"R Pandey","year":"2010","journal-title":"Menopause"},{"issue":"48","key":"ref22","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1039\/c2ob25722j","article-title":"Synthesis, optical resolution, absolute configuration, and osteogenic activity of cis-pterocarpans","volume":"10","author":"A Goel","year":"2012","journal-title":"Org Biomol Chem"},{"issue":"1","key":"ref23","first-page":"27","article-title":"Systemic bone formation with weekly PTH administration in ovariectomized rats","volume":"7","author":"SA Gittens","year":"2004","journal-title":"Journal of pharmacy & pharmaceutical sciences: a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/jbmr.434","article-title":"A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action","volume":"26","author":"K Sharan","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"355 Suppl","key":"ref25","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","author":"TA Einhorn","year":"1998","journal-title":"Clinical orthopaedics and related research"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00223-002-2120-4","article-title":"Establishment of a model of cortical bone repair in mice","volume":"73","author":"TM Campbell","year":"2003","journal-title":"Calcified tissue international"},{"issue":"27","key":"ref27","doi-asserted-by":"crossref","first-page":"19973","DOI":"10.1074\/jbc.M113.454652","article-title":"CCN3 protein participates in bone regeneration as an inhibitory factor","volume":"288","author":"Y Matsushita","year":"2013","journal-title":"J Biol Chem"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1002\/jcb.23287","article-title":"Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation","volume":"112","author":"GL Lin","year":"2011","journal-title":"J Cell Biochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bone.2015.09.003","article-title":"Bmp2 conditional knockout in osteoblasts and endothelial cells does not impair bone formation after injury or mechanical loading in adult mice","volume":"81","author":"SH McBride-Gagyi","year":"2015","journal-title":"Bone"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.bbrc.2013.10.155","article-title":"Sclerostin deficient mice rapidly heal bone defects by activating beta-catenin and increasing intramembranous ossification","volume":"441","author":"ME McGee-Lawrence","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"BT MacDonald","year":"2009","journal-title":"Dev Cell"},{"issue":"Pt 21","key":"ref32","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1242\/jcs.091991","article-title":"Inhibition of GSK3 by Wnt signalling\u2014two contrasting models","volume":"124","author":"C Metcalfe","year":"2011","journal-title":"J Cell Sci"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/dvg.20768","article-title":"Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling","volume":"49","author":"K Lenton","year":"2011","journal-title":"Genesis"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jor.21518","article-title":"Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration","volume":"30","author":"MI Dishowitz","year":"2012","journal-title":"J Orthop Res"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0092-8674(94)90195-3","article-title":"Notch is required for wingless signaling in the epidermis of Drosophila","volume":"79","author":"JP Couso","year":"1994","journal-title":"Cell"},{"issue":"34","key":"ref36","doi-asserted-by":"crossref","first-page":"32227","DOI":"10.1074\/jbc.M304001200","article-title":"Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways","volume":"278","author":"L Espinosa","year":"2003","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0144541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T01:18:00Z","timestamp":1653787080000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0144541"}},"subtitle":[],"editor":[{"given":"Yin","family":"Tintut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,11]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0144541","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,11]]}}}