{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:47:36Z","timestamp":1792259256212,"version":"4.4.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0144898","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T19:21:48Z","timestamp":1450380108000},"page":"e0144898","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["Polygenic Analysis of Late-Onset Alzheimer\u2019s Disease from Mainland China"],"prefix":"10.1371","volume":"10","author":[{"given":"Bin","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie Haitian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Miu Yee","family":"Waye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beisha","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer's disease","volume":"377","author":"C Ballard","year":"2011","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1212\/WNL.0b013e31821a44dd","article-title":"Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease","volume":"76","author":"M Balasa","year":"2011","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"M Gatz","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1951","DOI":"10.1016\/j.neurobiolaging.2014.02.014","article-title":"Mutational analysis in early-onset familial Alzheimer's disease in Mainland China","volume":"35","author":"B Jiao","year":"2014","journal-title":"Neurobiol Aging"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"LA Farrer","year":"1997","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"a006296","DOI":"10.1101\/cshperspect.a006296","article-title":"The genetics of Alzheimer disease","volume":"2","author":"RE Tanzi","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"R Guerreiro","year":"2013","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"JC Lambert","year":"2009","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature12825","article-title":"Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease","volume":"505","author":"C Cruchaga","year":"2014","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"936 e919","DOI":"10.1016\/j.neurobiolaging.2013.10.001","article-title":"Identification of C9orf72 repeat expansions in patients with amyotrophic lateral sclerosis and frontotemporal dementia in mainland China","volume":"35","author":"B Jiao","year":"2014","journal-title":"Neurobiol Aging"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/nm.3736","article-title":"A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death","volume":"20","author":"MK Wetzel-Smith","year":"2014","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"S Seshadri","year":"2010","journal-title":"JAMA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"AC Naj","year":"2011","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"JC Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"P Hollingworth","year":"2011","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"D Harold","year":"2009","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.cr.7290272","article-title":"SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci","volume":"15","author":"YY Shi","year":"2005","journal-title":"Cell Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.mgene.2014.04.010","article-title":"Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women","volume":"2","author":"MH Wang","year":"2014","journal-title":"Meta Gene"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1214\/13-AOS1175","article-title":"A SIGNIFICANCE TEST FOR THE LASSO","volume":"42","author":"R Lockhart","year":"2014","journal-title":"Ann Stat"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization Paths for Generalized Linear Models via Coordinate Descent","volume":"33","author":"J Friedman","year":"2010","journal-title":"J Stat Softw"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1001\/archneurol.2012.2052","article-title":"Comprehensive search for Alzheimer disease susceptibility loci in the APOE region","volume":"69","author":"G Jun","year":"2012","journal-title":"Arch Neurol"},{"key":"ref22","article-title":"A novel Alzheimer disease locus located near the gene encoding tau protein","author":"G Jun","year":"2015","journal-title":"Mol Psychiatry"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0169-328X(95)00097-C","article-title":"Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease","volume":"33","author":"P Bertrand","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neulet.2015.02.040","article-title":"Genetic associations of CLU rs9331888 polymorphism with Alzheimer's disease: A meta-analysis","volume":"591","author":"P Shuai","year":"2015","journal-title":"Neurosci Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.imbio.2011.07.017","article-title":"Complement receptor 1 (CR1) and Alzheimer's disease","volume":"217","author":"H Crehan","year":"2012","journal-title":"Immunobiology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ajhg.2011.05.019","article-title":"Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate","volume":"89","author":"IJ Kullo","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref27","article-title":"MS4A Cluster in Alzheimer's Disease","author":"J Ma","year":"2014","journal-title":"Mol Neurobiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/jamaneurol.2013.2815","article-title":"Genetic susceptibility for Alzheimer disease neuritic plaque pathology","volume":"70","author":"JM Shulman","year":"2013","journal-title":"JAMA Neurol"},{"key":"ref29","article-title":"Analyzing 54,936 Samples Supports the Association Between CD2AP rs9349407 Polymorphism and Alzheimer's Disease Susceptibility","author":"H Chen","year":"2015","journal-title":"Mol Neurobiol"},{"key":"ref30","first-page":"222","article-title":"TOMM40 gene polymorphism association with lipid profile","volume":"50","author":"RR Salakhov","year":"2014","journal-title":"Genetika"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2007.05.022","article-title":"GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers","volume":"54","author":"EM Reiman","year":"2007","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A mutation in APP protects against Alzheimer's disease and age-related cognitive decline","volume":"488","author":"T Jonsson","year":"2012","journal-title":"Nature"},{"key":"ref33","first-page":"232","article-title":"Neuropathologic and immunologic traits integrate the effect of CR1 and CD33 variants on Alzheimer's-related amyloid pathology Alzheimer's & Dementia: The Journal of the Alzheimer's Association","volume":"8","author":"P De Jager","year":"2012","journal-title":"Neuropathologic and immunologic traits integrate the effect of CR1 and CD33 variants on Alzheimer's-related amyloid pathology Alzheimer's & Dementia: The Journal of the Alzheimer's Association"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"486","DOI":"10.18632\/oncoscience.64","article-title":"Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease","volume":"1","author":"TN Beck","year":"2014","journal-title":"Oncoscience"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0144898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:39:21Z","timestamp":1540219161000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0144898"}},"subtitle":[],"editor":[{"given":"Riqiang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,17]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0144898","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,17]]}}}