{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:57:37Z","timestamp":1788969457132,"version":"build-2803163510"},"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145016","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T21:38:21Z","timestamp":1450215501000},"page":"e0145016","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating"],"prefix":"10.1371","volume":"10","author":[{"given":"Jan","family":"Balvan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaromir","family":"Gumulec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Raudenska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Krizova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Stepka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Babula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Kizek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojtech","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Masarik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/pros.2990230206","article-title":"P53 oncogene mutations in 3 human prostate-cancer cell-lines","volume":"23","author":"AG Carroll","year":"1993","journal-title":"Prostate"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jso.2930460108","article-title":"2 prostate carcinoma cell-lines demonstrate abnormalities in tumor suppressor genes","volume":"46","author":"SJ Rubin","year":"1991","journal-title":"Journal of Surgical Oncology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"27740","DOI":"10.1074\/jbc.M102559200","article-title":"The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity","volume":"276","author":"JA Gustin","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.eururo.2013.05.029","article-title":"The mutational landscape of prostate cancer","volume":"64","author":"CE Barbieri","year":"2013","journal-title":"Eur Urol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/pros.20411","article-title":"Loss of PTEN is associated with progression to androgen independence","volume":"66","author":"J Bertram","year":"2006","journal-title":"Prostate"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/pros.20447","article-title":"Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells","volume":"66","author":"Z Wu","year":"2006","journal-title":"Prostate"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-12-543","article-title":"PTEN genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity","volume":"12","author":"K Choucair","year":"2012","journal-title":"Bmc Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3892\/ijo.2013.2223","article-title":"Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle","volume":"44","author":"J Gumulec","year":"2014","journal-title":"International Journal of Oncology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/1568011053765967","article-title":"Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways","volume":"5","author":"Y Sedletska","year":"2005","journal-title":"Curr Med Chem Anticancer Agents"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081162","article-title":"Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions","volume":"8","author":"R Marullo","year":"2013","journal-title":"Plos One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11095-008-9533-3","article-title":"Plumbagin-induced Apoptosis in Human Prostate Cancer Cells is Associated with Modulation of Cellular Redox Status and Generation of Reactive Oxygen Species","volume":"25","author":"AA Powolny","year":"2008","journal-title":"Pharmaceutical Research"},{"key":"ref12","article-title":"Cytotoxicity Mechanism of Two Naphthoquinones (Menadione and Plumbagin) in Saccharomyces cerevisiae","volume":"3","author":"FAV Castro","year":"2008","journal-title":"Plos One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1074\/jbc.M601595200","article-title":"Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents","volume":"281","author":"SK Sandur","year":"2006","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"C1466","DOI":"10.1152\/ajpcell.00265.2005","article-title":"Mitochondrial density determines the cellular sensitivity to cisplatin-induced cell death","volume":"289","author":"W Qian","year":"2005","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072078","article-title":"Bioenergetic and Antiapoptotic Properties of Mitochondria from Cultured Human Prostate Cancer Cell Lines PC-3, DU145 and LNCaP","volume":"8","author":"A Panov","year":"2013","journal-title":"Plos One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e0121674","DOI":"10.1371\/journal.pone.0121674","article-title":"Multimodal holographic microscopy: distinction between apoptosis and oncosis","volume":"10","author":"J Balvan","year":"2015","journal-title":"Plos One"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2867-13-92","article-title":"Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal","volume":"13","author":"J Erenpreisa","year":"2013","journal-title":"Cancer Cell International"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/019262339702500116","article-title":"The pathways of cell death: Oncosis, apoptosis, and necrosis","volume":"25","author":"BF Trump","year":"1997","journal-title":"Toxicologic Pathology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"R Singh","year":"2009","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/cr.2014.133","article-title":"Entosis, a key player in cancer cell competition","volume":"24","author":"G Kroemer","year":"2014","journal-title":"Cell Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1091\/mbc.E13-07-0408","article-title":"mTOR regulates phagosome and entotic vacuole fission","volume":"24","author":"M Krajcovic","year":"2013","journal-title":"Molecular Biology of the Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","article-title":"Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis","volume":"10","author":"K Degenhardt","year":"2006","journal-title":"Cancer Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.1545107","article-title":"Autophagy suppresses tumor progression by limiting chromosomal instability","volume":"21","author":"R Mathew","year":"2007","journal-title":"Genes & Development"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1101\/gad.17558811","article-title":"The dynamic nature of autophagy in cancer","volume":"25","author":"AC Kimmelman","year":"2011","journal-title":"Genes & Development"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/onc.2013.96","article-title":"Generation of cancer stem-like cells through the formation of polyploid giant cancer cells","volume":"33","author":"S Zhang","year":"2014","journal-title":"Oncogene"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.4161\/cc.10.21.18128","article-title":"mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging","volume":"10","author":"JA Menendez","year":"2011","journal-title":"Cell Cycle"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"21990","DOI":"10.1364\/OE.18.021990","article-title":"Coherence-controlled holographic microscope","volume":"18","author":"P Kolman","year":"2010","journal-title":"Optics Express"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"14747","DOI":"10.1364\/OE.21.014747","article-title":"Off-axis setup taking full advantage of incoherent illumination in coherence-controlled holographic microscope","volume":"21","author":"T Slaby","year":"2013","journal-title":"Optics Express"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"541-","DOI":"10.1038\/169541a0","article-title":"Interference microscopy and mass determination","volume":"169","author":"HG Davies","year":"1952","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1364\/JOSA.47.000545","article-title":"Refractometry and interferometry of living cells","volume":"47","author":"R Barer","year":"1957","journal-title":"Journal of the Optical Society of America"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4161\/auto.21028","article-title":"A novel image-based cytometry method for autophagy detection in living cells","volume":"8","author":"LL-Y Chan","year":"2012","journal-title":"Autophagy"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2818.2009.03153.x","article-title":"Assessment of acridine orange and SYTO 16 for in vivo imaging of the peritoneal tissues in mice","volume":"234","author":"JA Udovich","year":"2009","journal-title":"Journal of Microscopy-Oxford"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1158\/1078-0432.CCR-09-0591","article-title":"Quantification of Circulating Endothelial Cells by Flow Cytometry Response","volume":"15","author":"P Mancuso","year":"2009","journal-title":"Clinical Cancer Research"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1472-765X.1997.tb00013.x","article-title":"SYTO16 labelling and flow cytometry of Mycobacterium avium","volume":"25","author":"P Ibrahim","year":"1997","journal-title":"Letters in Applied Microbiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-61779-108-6_10","article-title":"Rapid quantification of cell viability and apoptosis in B-cell lymphoma cultures using cyanine SYTO probes","volume":"740","author":"D Wlodkowic","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"33048","DOI":"10.1074\/jbc.M112.366690","article-title":"Electrophilic Aldehydes Generated by Sperm Metabolism Activate Mitochondrial Reactive Oxygen Species Generation and Apoptosis by Targeting Succinate Dehydrogenase","volume":"287","author":"RJ Aitken","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1038\/onc.2012.640","article-title":"Senescence and aging: the critical roles of p53","volume":"32","author":"A Rufini","year":"2013","journal-title":"Oncogene"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.devcel.2014.01.012","article-title":"Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast","volume":"28","author":"S Boeckler","year":"2014","journal-title":"Developmental Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"G Ashrafi","year":"2013","journal-title":"Cell Death and Differentiation"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/hsz-2012-0119","article-title":"Mitophagy: mechanisms, pathophysiological roles, and analysis","volume":"393","author":"W-X Ding","year":"2012","journal-title":"Biological Chemistry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial Fission, Fusion, and Stress","volume":"337","author":"RJ Youle","year":"2012","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095288","article-title":"Loss of PINK1 Impairs Stress-Induced Autophagy and Cell Survival","volume":"9","author":"D Parganlija","year":"2014","journal-title":"Plos One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"L Liu","year":"2012","journal-title":"Nature Cell Biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cmet.2014.12.003","article-title":"Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA","volume":"21","author":"AS Tan","year":"2015","journal-title":"Cell Metabolism"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nrm2529","article-title":"Autophagic cell death: the story of a misnomer","volume":"9","author":"G Kroemer","year":"2008","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1101\/gad.1565707","article-title":"Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis","volume":"21","author":"V Karantza-Wadsworth","year":"2007","journal-title":"Genes & Development"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/cr.2014.138","article-title":"Competition between human cells by entosis","volume":"24","author":"Q Sun","year":"2014","journal-title":"Cell Research"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/ncb2363","article-title":"Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes","volume":"13","author":"O Florey","year":"2011","journal-title":"Nature Cell Biology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/ncb2174","article-title":"A non-genetic route to aneuploidy in human cancers","volume":"13","author":"M Krajcovic","year":"2011","journal-title":"Nature Cell Biology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.febslet.2011.05.047","article-title":"Inhibition of NF-kappa B by MG132 through ER stress-mediated induction of LAP and LIP","volume":"585","author":"S Nakajima","year":"2011","journal-title":"Febs Letters"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"22443","DOI":"10.1074\/jbc.M801046200","article-title":"Differential control of the CCAAT\/enhancer-binding protein beta (C\/EBP beta) products liver-enriched transcriptional activating protein (LAP) and liver- enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the response to endoplasmic reticulum stress","volume":"283","author":"Y Li","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/sj.bjc.6605335","article-title":"Mutant p53 mediates survival of breast cancer cells","volume":"101","author":"LY Lim","year":"2009","journal-title":"British Journal of Cancer"},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041807","article-title":"Cells Expressing the C\/EBPbeta Isoform, LIP, Engulf Their Neighbors","volume":"7","author":"M Abreu","year":"2012","journal-title":"Plos One"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrc3789","article-title":"Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression","volume":"14","author":"CL Buchheit","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"ref55","article-title":"miR-200c Targets a NF-kappa B Up-Regulated TrkB\/NTF3 Autocrine Signaling Loop to Enhance Anoikis Sensitivity in Triple Negative Breast Cancer","volume":"7","author":"EN Howe","year":"2012","journal-title":"Plos One"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng1760","article-title":"The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells","volume":"38","author":"YH Loh","year":"2006","journal-title":"Nature Genetics"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"J Yu","year":"2007","journal-title":"Science"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3892\/ol.2012.916","article-title":"Expression of the pluripotency markers Oct3\/4, Nanog and Sox2 in human breast cancer cell lines","volume":"4","author":"G-Q Ling","year":"2012","journal-title":"Oncology Letters"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"K Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nature06534","article-title":"Reprogramming of human somatic cells to pluripotency with defined factors","volume":"451","author":"IH Park","year":"2008","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbrc.2011.06.082","article-title":"A population of BJ fibroblasts escaped from Ras-induced senescence susceptible to transformation","volume":"410","author":"S Kohsaka","year":"2011","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature04914","article-title":"Nanog promotes transfer of pluripotency after cell fusion","volume":"441","author":"J Silva","year":"2006","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/stem.1384","article-title":"Concise Review: Pursuing Self-Renewal and Pluripotency with the Stem Cell Factor Nanog","volume":"31","author":"A Saunders","year":"2013","journal-title":"Stem Cells"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.stem.2008.01.004","article-title":"Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells","volume":"2","author":"T Brambrink","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.yexcr.2010.04.030","article-title":"Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells","volume":"316","author":"K Salmina","year":"2010","journal-title":"Experimental Cell Research"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/stem.1721","article-title":"Molecular Evidence for OCT4-Induced Plasticity in Adult Human Fibroblasts Required for Direct Cell Fate Conversion to Lineage Specific Progenitors","volume":"32","author":"R Mitchell","year":"2014","journal-title":"Stem Cells"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/ijc.28319","article-title":"Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel","volume":"134","author":"S Zhang","year":"2014","journal-title":"International Journal of Cancer"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"25057","DOI":"10.1074\/jbc.M801073200","article-title":"CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase\/AKT-dependent Survivin Up-regulation","volume":"283","author":"H Roca","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"969","DOI":"10.4161\/auto.6822","article-title":"CCL2, survivin and autophagy\u2014New links with implications in human cancer","volume":"4","author":"H Roca","year":"2008","journal-title":"Autophagy"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1101\/gad.1963910","article-title":"Induced pluripotency: history, mechanisms, and applications","volume":"24","author":"M Stadtfeld","year":"2010","journal-title":"Genes & Development"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1634\/stemcells.2008-0346","article-title":"Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts","volume":"26","author":"P Mali","year":"2008","journal-title":"Stem Cells"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1074\/jbc.M114.590943","article-title":"p53 Protein-mediated Up-regulation of MAP Kinase Phosphatase 3 (MKP-3) Contributes to the Establishment of the Cellular Senescent Phenotype through Dephosphorylation of Extracellular Signal-regulated Kinase 1\/2 (ERK1\/2)","volume":"290","author":"H Zhang","year":"2015","journal-title":"Journal of Biological Chemistry"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1093\/emboj\/cdg417","article-title":"Reversal of human cellular senescence: roles of the p53 and p16 pathways","volume":"22","author":"CM Beausejour","year":"2003","journal-title":"Embo Journal"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1158\/1541-7786.MCR-10-0174","article-title":"p53-Dependent Induction of Prostate Cancer Cell Senescence by the PIM1 Protein Kinase","volume":"8","author":"M Zemskova","year":"2010","journal-title":"Molecular Cancer Research"},{"key":"ref75","article-title":"Number of Polyploid Giant Cancer Cells and Expression of EZH2 Are Associated with VM Formation and Tumor Grade in Human Ovarian Tumor","author":"L Zhang","year":"2014","journal-title":"Biomed Research International"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/aps.2013.68","article-title":"Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro","volume":"34","author":"Y-q Liu","year":"2013","journal-title":"Acta Pharmacologica Sinica"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1158\/1538-7445.AM2015-2899","article-title":"Abstract 2899: Mitophagy imparts enzalutamide resistance in prostate cancer","volume":"75","author":"HS Basu","year":"2015","journal-title":"Cancer Research"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1074\/jbc.M800102200","article-title":"Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia","volume":"283","author":"HF Zhang","year":"2008","journal-title":"Journal of Biological Chemistry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T18:40:16Z","timestamp":1599936016000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145016"}},"subtitle":[],"editor":[{"given":"Natasha","family":"Kyprianou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":78,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145016","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}