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Nature Publishing Group"},{"key":"ref19","unstructured":"Andrews S. FastQC A quality control tool for high throughput sequence data. In: Bioinformatics, Babraham [Internet]. 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/\" xlink:type=\"simple\">http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/<\/ext-link>"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"M Martin","year":"2010","journal-title":"EMBnet J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"B Langmead","year":"2009","journal-title":"Genome Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkr1090","article-title":"The Arabidopsis Information Resource (TAIR): improved gene annotation and new tools","volume":"40","author":"P Lamesch","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"D354","DOI":"10.1093\/nar\/gkh046","article-title":"PlantGDB, plant genome database and analysis tools","volume":"32","author":"Q Dong","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"SF Altschul","year":"1990","journal-title":"J Mol Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T22:28:08Z","timestamp":1540333688000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145065"}},"subtitle":[],"editor":[{"given":"Vinod","family":"Scaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,29]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145065","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,29]]}}}