{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:33:30Z","timestamp":1782830010123,"version":"3.54.5"},"reference-count":103,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145211","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T18:45:24Z","timestamp":1450291524000},"page":"e0145211","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK"],"prefix":"10.1371","volume":"10","author":[{"given":"Romina P.","family":"Salinas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo M.","family":"Ortiz Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas S.","family":"Distel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton O.","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda I.","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ber\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.cellbio.011209.122036","article-title":"Mechanical integration of actin and adhesion dynamics in cell migration","volume":"26","author":"ML Gardel","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1042\/BST0331260","article-title":"A role for actin in aging and apoptosis","volume":"33","author":"CW Gourlay","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e29469","DOI":"10.4161\/sgtp.29469","article-title":"Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking","volume":"5","author":"P Croise","year":"2014","journal-title":"Small GTPases"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.cellbio.21.020604.150721","article-title":"Rho GTPases: biochemistry and biology","volume":"21","author":"AB Jaffe","year":"2005","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrm2476","article-title":"Mammalian Rho GTPases: new insights into their functions from in vivo studies","volume":"9","author":"SJ Heasman","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.3390\/ijms14047089","article-title":"Roles of rho GTPases in intracellular transport and cellular transformation","volume":"14","author":"X Chi","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1042\/bj20031041","article-title":"Rho GTPases have diverse effects on the organization of the actin filament system","volume":"377","author":"P Aspenstrom","year":"2004","journal-title":"Biochem J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1016\/j.febslet.2008.04.033","article-title":"On the Rho&apos;d: the regulation of membrane protrusions by Rho-GTPases","volume":"582","author":"M Ladwein","year":"2008","journal-title":"FEBS Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/bj20030139","article-title":"Regulation of endocytic traffic by Rho GTPases","volume":"371","author":"B Qualmann","year":"2003","journal-title":"Biochem J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrm1940","article-title":"Harnessing actin dynamics for clathrin-mediated endocytosis","volume":"7","author":"M Kaksonen","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ncb1244","article-title":"Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2\/3 complex and F-actin dynamics","volume":"7","author":"T Dubois","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ejcb.2005.05.001","article-title":"Membrane trafficking at the ER\/Golgi interface: functional implications of RhoA and Rac1","volume":"84","author":"OB Matas","year":"2005","journal-title":"Eur J Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ceb.2010.10.007","article-title":"New mechanisms and functions of actin nucleation","volume":"23","author":"EN Firat-Karalar","year":"2011","journal-title":"Curr Opin Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.devcel.2006.05.001","article-title":"Staying in shape with formins","volume":"10","author":"J Faix","year":"2006","journal-title":"Dev Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbamcr.2010.01.014","article-title":"Fifteen formins for an actin filament: a molecular view on the regulation of human formins","volume":"1803","author":"A Schonichen","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1371\/journal.pbio.0050317","article-title":"Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells","volume":"5","author":"C Yang","year":"2007","journal-title":"PLoS Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1074\/jbc.M111.305102","article-title":"mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation","volume":"287","author":"WI Goh","year":"2012","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/11056","article-title":"Cooperation between mDia1 and ROCK in Rho-induced actin reorganization","volume":"1","author":"N Watanabe","year":"1999","journal-title":"Nat Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1083\/jcb.200511093","article-title":"Stress fibers are generated by two distinct actin assembly mechanisms in motile cells","volume":"173","author":"P Hotulainen","year":"2006","journal-title":"J Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.yexcr.2006.10.033","article-title":"RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking","volume":"313","author":"BJ Wallar","year":"2007","journal-title":"Exp Cell Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.cub.2005.09.051","article-title":"A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages","volume":"15","author":"E Colucci-Guyon","year":"2005","journal-title":"Curr Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1093\/emboj\/16.11.3044","article-title":"p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin","volume":"16","author":"N Watanabe","year":"1997","journal-title":"EMBO J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.200612071","article-title":"Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation","volume":"178","author":"DT Brandt","year":"2007","journal-title":"J Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1126\/science.275.5304.1308","article-title":"Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase","volume":"275","author":"M Amano","year":"1997","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yexcr.2004.08.012","article-title":"Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility","volume":"301","author":"AP Wheeler","year":"2004","journal-title":"Exp Cell Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tcb.2005.05.004","article-title":"Regulation of myosin II during cytokinesis in higher eukaryotes","volume":"15","author":"F Matsumura","year":"2005","journal-title":"Trends Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.emboj.7601522","article-title":"PSGL-1 and mTOR regulate translation of ROCK-1 and physiological functions of macrophages","volume":"26","author":"R Fox","year":"2007","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0960-9822(02)01069-2","article-title":"Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis","volume":"12","author":"IM Olazabal","year":"2002","journal-title":"Curr Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1083\/jcb.200412043","article-title":"The Rho kinases I and II regulate different aspects of myosin II activity","volume":"170","author":"A Yoneda","year":"2005","journal-title":"J Cell Biol"},{"key":"ref30","first-page":"181","article-title":"Hijacking of eukaryotic functions by intracellular bacterial pathogens","volume":"7","author":"A Alonso","year":"2004","journal-title":"Int Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1083\/jcb.201105019","article-title":"Subversion of membrane transport pathways by vacuolar pathogens","volume":"195","author":"E Alix","year":"2011","journal-title":"J Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.immunol.20.103001.114744","article-title":"Phagocytosis of microbes: complexity in action","volume":"20","author":"DM Underhill","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-pathol-011811-132445","article-title":"The cell biology of phagocytosis","volume":"7","author":"RS Flannagan","year":"2012","journal-title":"Annu Rev Pathol"},{"key":"ref34","article-title":"How nascent phagosomes mature to become phagolysosomes","author":"GD Fairn","year":"2012","journal-title":"Trends Immunol"},{"key":"ref35","first-page":"43","article-title":"Regulation of phagocytosis by Rho GTPases","volume":"291","author":"F Niedergang","year":"2005","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.282.5394.1717","article-title":"Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases","volume":"282","author":"E Caron","year":"1998","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1091\/mbc.E03-11-0847","article-title":"Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis","volume":"15","author":"AD Hoppe","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.1074\/jbc.M513731200","article-title":"Dissociation of recruitment and activation of the small G-protein Rac during Fcgamma receptor-mediated phagocytosis","volume":"281","author":"C Cougoule","year":"2006","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.1074\/jbc.M111.257634","article-title":"Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages","volume":"287","author":"JG Kim","year":"2012","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/35008673","article-title":"Involvement of the Arp2\/3 complex in phagocytosis mediated by FcgammaR or CR3","volume":"2","author":"RC May","year":"2000","journal-title":"Nat Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1084\/jem.186.6.955","article-title":"Rho is required for the initiation of calcium signaling and phagocytosis by Fcgamma receptors in macrophages","volume":"186","author":"DJ Hackam","year":"1997","journal-title":"J Exp Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.immuni.2006.02.005","article-title":"Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis","volume":"24","author":"AB Hall","year":"2006","journal-title":"Immunity"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.rvsc.2003.09.001","article-title":"Q fever (coxiellosis): epidemiology and pathogenesis","volume":"77","author":"Z Woldehiwet","year":"2004","journal-title":"Res Vet Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.1016\/j.vaccine.2007.08.002","article-title":"Coxiella burnetii: host and bacterial responses to infection","volume":"25","author":"DM Waag","year":"2007","journal-title":"Vaccine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/MMBR.47.2.127-149.1983","article-title":"Q fever and Coxiella burnetii: a model for host-parasite interactions","volume":"47","author":"OG Baca","year":"1983","journal-title":"Microbiol Rev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1128\/IAI.70.10.5816-5821.2002","article-title":"Coxiella burnetii localizes in a Rab7-labeled compartment with autophagic characteristics","volume":"70","author":"W Beron","year":"2002","journal-title":"Infect Immun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1128\/IAI.68.7.3815-3821.2000","article-title":"Coxiella burnetii exhibits morphological change and delays phagolysosomal fusion after internalization by J774A.1 cells","volume":"68","author":"D Howe","year":"2000","journal-title":"Infect Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1462-5822.2006.00838.x","article-title":"The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell","volume":"9","author":"PS Romano","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1462-5822.2007.00901.x","article-title":"Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii","volume":"9","author":"DE Voth","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1462-5822.2005.00527.x","article-title":"Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles","volume":"7","author":"MG Gutierrez","year":"2005","journal-title":"Cell Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1128\/IAI.00301-09","article-title":"Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii","volume":"77","author":"M Aguilera","year":"2009","journal-title":"Infect Immun"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e39348","DOI":"10.1371\/journal.pone.0039348","article-title":"Cortactin is involved in the entry of Coxiella burnetii into non-phagocytic cells","volume":"7","author":"EM Rosales","year":"2012","journal-title":"PLoS One"},{"key":"ref53","first-page":"143","article-title":"Entry of Coxiella burnetii into host cells","volume":"37","author":"OG Baca","year":"1993","journal-title":"Acta Virol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.4049\/jimmunol.163.11.6078","article-title":"Subversion of monocyte functions by coxiella burnetii: impairment of the cross-talk between alphavbeta3 integrin and CR3","volume":"163","author":"C Capo","year":"1999","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1128\/IAI.68.10.5673-5678.2000","article-title":"alpha(v)beta(3) integrin and bacterial lipopolysaccharide are involved in Coxiella burnetii-stimulated production of tumor necrosis factor by human monocytes","volume":"68","author":"J Dellacasagrande","year":"2000","journal-title":"Infect Immun"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1128\/IAI.66.11.5527-5533.1998","article-title":"Coxiella burnetii induces reorganization of the actin cytoskeleton in human monocytes","volume":"66","author":"S Meconi","year":"1998","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.yexcr.2013.04.021","article-title":"Hijacking of Rho GTPases during bacterial infection","volume":"319","author":"E Lemichez","year":"2013","journal-title":"Exp Cell Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrmicro1150","article-title":"Bacterial cytotoxins: targeting eukaryotic switches","volume":"3","author":"K Aktories","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1016\/j.febslet.2006.04.100","article-title":"Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B","volume":"580","author":"H Genth","year":"2006","journal-title":"FEBS Lett"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/jcs.114.6.1061","article-title":"Phagocytosis and the actin cytoskeleton","volume":"114","author":"RC May","year":"2001","journal-title":"J Cell Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0076-6879(00)25466-9","article-title":"Rho GTPases and macrophage phagocytosis","volume":"325","author":"JC Patel","year":"2000","journal-title":"Methods Enzymol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0076-6879(06)06022-8","article-title":"The use of GFP to localize Rho GTPases in living cells","volume":"406","author":"D Michaelson","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"25150","DOI":"10.1074\/jbc.M800882200","article-title":"Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification","volume":"283","author":"PJ Roberts","year":"2008","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1016\/j.yexcr.2007.07.002","article-title":"Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension","volume":"313","author":"K Bhadriraju","year":"2007","journal-title":"Exp Cell Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/cm.20472","article-title":"Rho-kinase\/ROCK: A key regulator of the cytoskeleton and cell polarity","volume":"67","author":"M Amano","year":"2010","journal-title":"Cytoskeleton (Hoboken)"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ejcb.2010.06.001","article-title":"Phospholipids regulate localization and activity of mDia1 formin","volume":"89","author":"N Ramalingam","year":"2010","journal-title":"Eur J Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1074\/jbc.M006205200","article-title":"Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain","volume":"276","author":"AS Alberts","year":"2001","journal-title":"J Biol Chem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1074\/jbc.M411605200","article-title":"Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1","volume":"280","author":"F Li","year":"2005","journal-title":"J Biol Chem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ceb.2010.05.006","article-title":"Manipulation of host membrane machinery by bacterial pathogens","volume":"22","author":"P Cossart","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cell.2006.02.012","article-title":"Bacterial adhesion and entry into host cells","volume":"124","author":"J Pizarro-Cerda","year":"2006","journal-title":"Cell"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0962-8924(00)88956-4","article-title":"Phagocytosis by zippers and triggers","volume":"5","author":"JA Swanson","year":"1995","journal-title":"Trends Cell Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrmicro3049","article-title":"Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii","volume":"11","author":"EJ van Schaik","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1084\/jem.184.2.627","article-title":"Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages","volume":"184","author":"LA Allen","year":"1996","journal-title":"J Exp Med"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1365-3083.1977.tb02153.x","article-title":"Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages","volume":"6","author":"G Kaplan","year":"1977","journal-title":"Scand J Immunol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fmicb.2010.00137","article-title":"Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation","volume":"1","author":"SK Hussain","year":"2010","journal-title":"Front Microbiol"},{"key":"ref76","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00606-12","article-title":"Host Pathways Important for Coxiella burnetii Infection Revealed by Genome-Wide RNA Interference Screening","volume":"4","author":"JA McDonough","year":"2013","journal-title":"MBio"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e54566","DOI":"10.1371\/journal.pone.0054566","article-title":"Effector Protein Translocation by the Coxiella burnetii Dot\/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole","volume":"8","author":"HJ Newton","year":"2013","journal-title":"PLoS One"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1462-5822.2005.00540.x","article-title":"New concepts in Salmonella virulence: the importance of reducing the intracellular growth rate in the host","volume":"7","author":"A Tierrez","year":"2005","journal-title":"Cell Microbiol"},{"key":"ref79","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010009","article-title":"Entry of Listeria monocytogenes in mammalian epithelial cells: an updated view","volume":"2","author":"J Pizarro-Cerda","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1242\/jcs.01247","article-title":"Analysis of Chlamydia caviae entry sites and involvement of Cdc42 and Rac activity","volume":"117","author":"A Subtil","year":"2004","journal-title":"J Cell Sci"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0076-6879(07)00411-9","article-title":"Investigating the function of Rho family GTPases during Salmonella\/host cell interactions","volume":"439","author":"JC Patel","year":"2008","journal-title":"Methods Enzymol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1398-9219.2004.00184.x","article-title":"Requirement for the Rac GTPase in Chlamydia trachomatis invasion of non-phagocytic cells","volume":"5","author":"RA Carabeo","year":"2004","journal-title":"Traffic"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/emboj\/21.4.560","article-title":"Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways","volume":"21","author":"O Billker","year":"2002","journal-title":"EMBO J"},{"issue":"Pt 2","key":"ref84","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3480241","article-title":"Rho GTPases and their effector proteins","volume":"348","author":"AL Bishop","year":"2000","journal-title":"Biochem J"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1074\/jbc.274.19.13198","article-title":"Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases","volume":"274","author":"V Benard","year":"1999","journal-title":"J Biol Chem"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/jcs.01117","article-title":"Designing biosensors for Rho family proteins\u2014deciphering the dynamics of Rho family GTPase activation in living cells","volume":"117","author":"O Pertz","year":"2004","journal-title":"J Cell Sci"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1242\/jcs.064345","article-title":"Spatio-temporal Rho GTPase signaling\u2014where are we now?","volume":"123","author":"O Pertz","year":"2010","journal-title":"J Cell Sci"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/emboj\/18.3.578","article-title":"Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton","volume":"18","author":"XD Ren","year":"1999","journal-title":"EMBO J"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.152.1.111","article-title":"Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding","volume":"152","author":"D Michaelson","year":"2001","journal-title":"J Cell Biol"},{"key":"ref90","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb1411s46","article-title":"Biosensors for characterizing the dynamics of rho family GTPases in living cells","volume":"14","author":"L Hodgson","year":"2010","journal-title":"Curr Protoc Cell Biol Chapter"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.200104037","article-title":"A role for cofilin and LIM kinase in Listeria-induced phagocytosis","volume":"155","author":"H Bierne","year":"2001","journal-title":"J Cell Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1242\/jcs.02285","article-title":"WASP-related proteins, Abi1 and Ena\/VASP are required for Listeria invasion induced by the Met receptor","volume":"118","author":"H Bierne","year":"2005","journal-title":"J Cell Sci"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1574-6968.2007.00768.x","article-title":"Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus","volume":"272","author":"CA Burnham","year":"2007","journal-title":"FEMS Microbiol Lett"},{"key":"ref94","article-title":"Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses","author":"JG Duman","year":"2015","journal-title":"Neurosci Lett"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1242\/jcs.02384","article-title":"RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1","volume":"118","author":"M Fernandez-Borja","year":"2005","journal-title":"J Cell Sci"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/IAI.00252-09","article-title":"Requirement for formin-induced actin polymerization during spread of Shigella flexneri","volume":"78","author":"JE Heindl","year":"2010","journal-title":"Infect Immun"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ncb2109","article-title":"Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility","volume":"12","author":"CM Haglund","year":"2010","journal-title":"Nat Cell Biol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.chom.2007.03.005","article-title":"A type III secretion system in Vibrio cholerae translocates a formin\/spire hybrid-like actin nucleator to promote intestinal colonization","volume":"1","author":"VC Tam","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1111\/cmi.12173","article-title":"Formin-mediated actin polymerization promotes Salmonella invasion","volume":"15","author":"D Truong","year":"2013","journal-title":"Cell Microbiol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1097-2765(00)80399-8","article-title":"Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling","volume":"5","author":"T Tominaga","year":"2000","journal-title":"Mol Cell"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.chom.2011.03.009","article-title":"Activation of a RhoA\/myosin II-dependent but Arp2\/3 complex-independent pathway facilitates Salmonella invasion","volume":"9","author":"J Hanisch","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0882-4010(03)00090-1","article-title":"Outer membrane protein A and cytotoxic necrotizing factor-1 use diverse signaling mechanisms for Escherichia coli K1 invasion of human brain microvascular endothelial cells","volume":"35","author":"NA Khan","year":"2003","journal-title":"Microb Pathog"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1128\/JVI.00504-07","article-title":"Equine herpesvirus 1 enters cells by two different pathways, and infection requires the activation of the cellular kinase ROCK1","volume":"81","author":"AR Frampton Jr.","year":"2007","journal-title":"J Virol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T05:22:27Z","timestamp":1692163347000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145211"}},"subtitle":[],"editor":[{"given":"Daniel E.","family":"Voth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,16]]},"references-count":103,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145211","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,16]]}}}