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Libro Blanco del Parkinson en Espa\u00f1a. Real Patronato sobre Discapacidad (Ministerio de Sanidad, Servicios Sociales e Igualdad). 2015. Available at: http:\/\/www.fedesparkinson.org\/libro_blanco.pdf<\/ext-link>. Accessed: July 2015."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1468-1331.2011.03532.x","article-title":"Move for Change Part I: a European survey evaluating the impact f teh EPDA Charter for People with Parkinson\u2019s disease","volume":"19","author":"BR Bloem","year":"2012","journal-title":"European Journal of Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.euroneuro.2011.08.008","article-title":"Cost of disorders of the brain in Europe 2010","volume":"21","author":"A Gustavsson","year":"2011","journal-title":"European Neuropsychopharmacology"},{"issue":"1\u20132","key":"ref6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jns.2010.04.011","article-title":"Trends in resource utilization for Parkinson\u2019s disease in Germany","volume":"294","author":"Y Winter","year":"2010","journal-title":"Journal of the Neurological Sciences"},{"issue":"Suppl.","key":"ref7","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.parkreldis.2007.06.003","article-title":"The economic impact of Parkinson\u2019s disease","volume":"13","author":"LJ Findley","year":"2007","journal-title":"Parkinsonism & Related Disorders"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.17925\/ENR.2013.08.01.6","article-title":"Heath economics and cost of illness in Parkinson\u2019s disease","volume":"8","author":"C Mateus","year":"2013","journal-title":"European Neurological Review"},{"issue":"Suppl.1","key":"ref9","first-page":"13","article-title":"Interpreting Health Economics Data in Parkinson\u2019s disease","volume":"6","author":"R Dodel","year":"2011","journal-title":"European Neurological Review"},{"key":"ref10","article-title":"Informe de la fundaci\u00f3n del cerebro sobre el impacto social de la enfermedad de Parkinson en Espa\u00f1a","author":"R Garc\u00eda Ramos","year":"2013","journal-title":"Neurolog\u00eda"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1353-8020(02)00097-4","article-title":"Economic burden and quality of life impairment increase with severity of PD","volume":"9","author":"T Ker\u00e4nen","year":"2003","journal-title":"Parkinsonism Relat Disord"},{"issue":"7","key":"ref12","first-page":"S168","article-title":"The economic and quality of life burden associated with Parkinson\u2019s disease: a focus on symptoms","volume":"18","author":"D Boland","year":"2012","journal-title":"Am J Manag Care"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.33588\/rn.4206.2006041","article-title":"Estudio longitudinal de pacientes con enfermedad de Parkinson (ELEP): objetivos y metodolog\u00eda","volume":"42","year":"2006","journal-title":"Rev Neurol"},{"key":"ref14","first-page":"181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease. A clinico-pathological study of 100 cases","volume":"55","author":"AJ Hughes","year":"1992","journal-title":"JNNP"},{"key":"ref15","unstructured":"Oblikue consulting. eSalud. Online medical economic database. Acceded: November 2012. Available at: http:\/\/oblikue.com\/bdcostes\/<\/ext-link>. Accessed July 2013."},{"key":"ref16","unstructured":"Consejo General de Colegios Oficiales de Farmac\u00e9uticos. Bot Plus Web. Available at: https:\/\/botplusweb.portalfarma.com\/<\/ext-link>. Accessed July 2013."},{"key":"ref17","unstructured":"Bolet\u00edn Oficial del Estado N\u00b0 122, 23 de mayo de 2011. Available at: http:\/\/www.boe.es\/boe\/dias\/2011\/05\/23\/pdfs\/BOE-S-2011-122.pdf<\/ext-link>. Accessed July 2013."},{"key":"ref18","unstructured":"Bolet\u00edn Oficial del Estado N\u00b0 314, 31 de diciembre de 2011. Available at: http:\/\/www.boe.es\/boe\/dias\/2012\/12\/31\/pdfs\/BOE-S-2012-314.pdf<\/ext-link>. Accessed July 2013."},{"issue":"3","key":"ref19","first-page":"83","article-title":"Estimaci\u00f3n de los costes de los cuidados informales asociados a enfermedades neurol\u00f3gicas de alta prevalencia en Espa\u00f1a","volume":"4","author":"J Olivia","year":"2007","journal-title":"Pharmacoeconomics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.artmed.2013.04.002","article-title":"Unveiling relevant non-motor Parkinson\u2019s disease severity symptoms using machine learning approach","volume":"58","author":"R Arma\u00f1azas","year":"2013","journal-title":"Artif Intell Med"},{"key":"ref21","article-title":"R: A language and environment for statistical computing","year":"2012"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Pinheiro J, Bates D, DebRoy S, Sarkar D, EISPACK authors. Linear and Nonlinear Mixed Effects Models. R package version 3. 2013:1\u2013113. Available at: https:\/\/cran.r-project.org\/web\/packages\/nlme\/nlme.pdf<\/ext-link>. Accessed July 2014.","DOI":"10.32614\/CRAN.package.nlme"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.euroneuro.2010.08.002","article-title":"Cost of illness and care in Parkinson\u2019s disease: an evaluation on six countries","volume":"21","author":"s Von Campenhausen","year":"2011","journal-title":"Eur Neuropsychopharm"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1353-8020(00)00079-1","article-title":"Longitudinal evaluation of economic and physical impact of Parkinson\u2019s disease","volume":"8","author":"M Schenkman","year":"2001","journal-title":"Parkinsonism and Related Disorders"},{"issue":"1","key":"ref25","first-page":"15","article-title":"Impacto de los s\u00edntomas motores y no motores en los costes directos de la enfermedad de Parkinson","volume":"21","author":"E Cubo","year":"2009","journal-title":"Neurolog\u00eda"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.parkreldis.2007.06.003","article-title":"The economic impact of Parkinson\u2019s disease","volume":"13","author":"LJ Findley","year":"2007","journal-title":"Parkinsonism Relat Disord"},{"key":"ref27","first-page":"S40","article-title":"Parkinson\u2019s disease\u2014Part I: Pathophysiology, symptoms, burden, diagnosis and assessment","volume":"14","author":"D Weintraub","year":"2008","journal-title":"Am J Manag Care"},{"issue":"5","key":"ref28","first-page":"264","article-title":"Estudio de cohortes sobre la carga socioecon\u00f3mica de la enfermedad de Parkinson en Portugal","volume":"52","author":"JP Reese","year":"2011","journal-title":"Neurologia"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/mds.23661","article-title":"The economic impact of cognitive impairment in Parkinson\u2019s disease","volume":"26","author":"C Vossius","year":"2011","journal-title":"Movement Disord"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2011.11.002","article-title":"Impact of complications and comorbidities on treatment cost and Health related quality of life of patients with Parkinson\u2019s disease","volume":"314","author":"JP Bach","year":"2012","journal-title":"J Neurol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s40258-013-0033-1","article-title":"Compliance with pharmacotherapy and direct healthcare costs in patients with Parkinson\u2019s disease: a retrospective claims database analysis","volume":"11","author":"FF Richy","year":"2013","journal-title":"Appl Heath Econ Health Policy"},{"key":"ref32","first-page":"S49","article-title":"Parkinson\u2019s disease\u2014Part 2: treatment of motor symptoms","volume":"14","author":"D Weintraub","year":"2008","journal-title":"Am J Manag Care"},{"issue":"S1","key":"ref33","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1002\/mds.22716","article-title":"Pain in Parkinson\u2019s","volume":"25","author":"B Ford","year":"2010","journal-title":"Movement Disord"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1186\/1471-2458-13-1229","article-title":"The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care","volume":"13","author":"H Breivik","year":"2013","journal-title":"BMC Public Health"},{"issue":"S1","key":"ref35","doi-asserted-by":"crossref","first-page":"S222","DOI":"10.1016\/S1353-8020(11)70068-2","article-title":"Epidemiology and clinical phenomenology for Parkinson\u2019s disease with pain and fatigue","volume":"18","author":"HB Wen","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"key":"ref36","article-title":"Handbook of Non Motor symptoms in Parkinson Disease","author":"KR Chaudhuri","year":"2011"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T22:43:40Z","timestamp":1748731420000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145310"}},"subtitle":[],"editor":[{"given":"Fernando","family":"de Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,23]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145310","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,23]]}}}