{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:05:31Z","timestamp":1782439531890,"version":"3.54.5"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145392","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T20:34:29Z","timestamp":1453235669000},"page":"e0145392","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation"],"prefix":"10.1371","volume":"11","author":[{"given":"Anael Viana Pinto","family":"Alberto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Xavier","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao Ricardo Lacerda","family":"de Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Surrage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Cristina","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Gomes Braga","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valber da Silva","family":"Frutuoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Anast\u00e1cio","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"C577","DOI":"10.1152\/ajpcell.1993.265.3.C577","article-title":"Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides","volume":"265","author":"GR Dubyak","year":"1993","journal-title":"AmJ Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0031-6865(94)00043-U","article-title":"Current state of purinoceptor research","volume":"69","author":"G Burnstock","year":"1995","journal-title":"Pharmaceutica acta Helvetiae"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-5793(00)02306-1","article-title":"P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production","volume":"486","author":"D Ferrari","year":"2000","journal-title":"FEBS letters"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1067\/mai.2001.114658","article-title":"Effects of purine and pyrimidine nucleotides on intracellular Ca2+ in human eosinophils: activation of purinergic P2Y receptors","volume":"107","author":"JG Mohanty","year":"2001","journal-title":"The Journal of allergy and clinical immunology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/371516a0","article-title":"A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP","volume":"371","author":"S Valera","year":"1994","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1748","article-title":"Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils","volume":"10","author":"K Chen","year":"2009","journal-title":"Nat Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0167-5699(95)80045-X","article-title":"The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death","volume":"16","author":"F Di Virgilio","year":"1995","journal-title":"Immunol Today"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"V Ralevic","year":"1998","journal-title":"Pharmacol Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/S0100-879X2008005000037","article-title":"Purinergic signalling: past, present and future","volume":"42","author":"G Burnstock","year":"2009","journal-title":"Braz J Med Biol Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jaci.2009.11.029","article-title":"Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules","volume":"125","author":"JS Neves","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1182\/blood.V95.3.973.003k47_973_978","article-title":"Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils","volume":"95","author":"S Dichmann","year":"2000","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jcp.1129","article-title":"Functional characterization of P2Y and P2X receptors in human eosinophils","volume":"188","author":"M Idzko","year":"2001","journal-title":"Journal of cellular physiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/sj.bjp.0705145","article-title":"Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils","volume":"138","author":"M Idzko","year":"2003","journal-title":"British journal of pharmacology"},{"key":"ref14","first-page":"215","article-title":"Innate immune function of eosinophils: from antiparasite to antitumor cells","volume":"415","author":"F Legrand","year":"2008","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0952-7915(96)80006-9","article-title":"Eosinophils in allergic reactions","volume":"8","author":"P Desreumaux","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0091-6749(90)90151-S","article-title":"The eosinophil and bronchial asthma: current understanding","volume":"85","author":"GJ Gleich","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"ref17","first-page":"248","article-title":"T cells and asthma. II. Regulation of the eosinophilia of asthma by T cell cytokines","volume":"94","author":"C Walker","year":"1991","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1749-6632.1994.tb39808.x","article-title":"Eosinophil tissue mobilization in allergic disorders","volume":"725","author":"PL Bruijnzeel","year":"1994","journal-title":"Ann N Y Acad Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"961","DOI":"10.4049\/jimmunol.141.3.961","article-title":"Eosinophils from granulomas in murine schistosomiasis mansoni produce substance P","volume":"141","author":"JV Weinstock","year":"1988","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1189\/jlb.0404228","article-title":"Eosinophils function as antigen-presenting cells","volume":"76","author":"HZ Shi","year":"2004","journal-title":"J Leukoc Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1128\/IAI.02067-05","article-title":"Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis","volume":"74","author":"UM Padigel","year":"2006","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1073\/pnas.88.16.7430","article-title":"Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1","volume":"88","author":"PF Weller","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-l beta-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"L Agostini","year":"2004","journal-title":"Immunity"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1365-2222.2007.02740.x","article-title":"Animal models of asthma","volume":"37","author":"GR Zosky","year":"2007","journal-title":"Clinical and Experimental Allergy"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1365-2222.2007.02884.x","article-title":"Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation","volume":"38","author":"GR Zosky","year":"2008","journal-title":"Clinical and Experimental Allergy"},{"key":"ref26","first-page":"1151","article-title":"Chemotactic effect of PAF-acether on peritoneal eosinophils from normal rats","volume":"22","author":"MA Martins","year":"1989","journal-title":"Braz J Med Biol Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/jlb.53.1.104","article-title":"Role of PAF in the allergic pleurisy caused by ovalbumin in actively sensitized rats","volume":"53","author":"MA Martins","year":"1993","journal-title":"J Leukoc Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0074-7696(04)40002-3","article-title":"Cellular distribution and functions of P2 receptor subtypes in different systems","volume":"240","author":"G Burnstock","year":"2004","journal-title":"IntRev Cytol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0165-6147(02)00038-X","article-title":"Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family","volume":"24","author":"MP Abbracchio","year":"2003","journal-title":"Trends PharmacolSci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/sj.bjp.0702732","article-title":"Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes","volume":"127","author":"CB Grahames","year":"1999","journal-title":"Br J Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuropharm.2008.06.067","article-title":"ATP-gated P2X cation-channels","volume":"56","author":"MF Jarvis","year":"2009","journal-title":"Neuropharmacology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.pharmthera.2005.08.014","article-title":"Pharmacological profiles of cloned mammalian P2Y-receptor subtypes","volume":"110","author":"I von Kugelgen","year":"2006","journal-title":"Pharmacol Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.4049\/jimmunol.181.3.2181","article-title":"Activation of human alveolar macrophages via P2 receptors: coupling to intracellular Ca2+ increases and cytokine secretion","volume":"181","author":"D Myrtek","year":"2008","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11302-006-9032-0","article-title":"Chemotactic activity of extracellular nucleotides on human immune cells","author":"D Myrtek","year":"2007","journal-title":"Purinergic Signalling"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bjp.0705459","article-title":"P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages","volume":"140","author":"JW Bowler","year":"2003","journal-title":"Br J Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bcp.2004.11.012","article-title":"Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages","volume":"69","author":"R Coutinho-Silva","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"ref37","first-page":"959","article-title":"Purinergic signalling: ATP release","volume":"26","author":"P Bodin","year":"2001","journal-title":"NeurochemRes"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1398-9995.2010.02426.x","article-title":"The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation","volume":"65","author":"T M\u00fcller","year":"2010","journal-title":"Allergy"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.4049\/jimmunol.0903908","article-title":"P2Y2 receptor regulates VCAM-1 membrane and soluble forms and eosinophil accumulation during lung inflammation","volume":"185","author":"G Vanderstocken","year":"2010","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nm1617","article-title":"Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells","volume":"13","author":"M Idzko","year":"2007","journal-title":"Nature medicine"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"C1050","DOI":"10.1152\/ajpcell.00138.2013","article-title":"Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli","volume":"305","author":"DV Ilatovskaya","year":"2013","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T05:07:25Z","timestamp":1748754445000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145392"}},"subtitle":[],"editor":[{"given":"Christianne","family":"Bandeira de Melo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145392","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}