{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:45:27Z","timestamp":1773337527782,"version":"3.50.1"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145468","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T18:42:31Z","timestamp":1450896151000},"page":"e0145468","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Na\u00efve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)"],"prefix":"10.1371","volume":"10","author":[{"given":"Keisuke","family":"Izumi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misato","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"EH Choy","year":"2001","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"IB McInnes","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"D Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/art.30213","article-title":"Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor","volume":"63","author":"DJ Todd","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/14397595.2014.897793","article-title":"Tocilizumab is clinically, functionally, and radiographically effective and safe either with or without low-dose methotrexate in active rheumatoid arthritis patients with inadequate responses to DMARDs and\/or TNF inhibitors: A single-center retrospective cohort study (KEIO-TCZ study) at week 52","volume":"25","author":"K Izumi","year":"2015","journal-title":"Mod Rheumatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3109\/s10165-010-0409-0","article-title":"In rheumatoid arthritis patients treated with tocilizumab, the rate of clinical disease activity index (CDAI) remission at 24 weeks is superior in those with higher titers of IgM-rheumatoid factor at baseline","volume":"21","author":"SY Kawashiri","year":"2011","journal-title":"Mod Rheumatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.semarthrit.2012.11.007","article-title":"Rheumatoid factor as predictor of response to abatacept, rituximab and tocilizumab in rheumatoid arthritis: Systematic review and meta-analysis","volume":"43","author":"RJ Maneiro","year":"2013","journal-title":"Semin Arthritis Rheum"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/annrheumdis-2013-204137","article-title":"Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy","volume":"73","author":"N Nishina","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3109\/s10165-012-0782-y","article-title":"Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis","volume":"23","author":"T Kojima","year":"2013","journal-title":"Mod Rheumatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/acr.20188","article-title":"Predictors for remission in rheumatoid arthritis patients: A systematic review","volume":"62","author":"W Katchamart","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1172\/JCI200523273","article-title":"Role of osteopontin in amplification and perpetuation of rheumatoid synovitis","volume":"115","author":"G Xu","year":"2005","journal-title":"J Clin Invest"},{"key":"ref13","first-page":"2061","article-title":"Enhanced local production of osteopontin in rheumatoid joints","volume":"29","author":"S Ohshima","year":"2002","journal-title":"J Rheumatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1136\/annrheumdis-2013-204581","article-title":"Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene","volume":"74","author":"S Gazal","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1002\/art.25020","article-title":"Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances production of interleukin-6","volume":"60","author":"Y Take","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1073\/pnas.052523599","article-title":"Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice","volume":"99","author":"K Yumoto","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00296-009-0885-8","article-title":"IL-6\/sIL-6R trans-signalling, but not TNF-alpha induced angiogenesis in a HUVEC and synovial cell co-culture system","volume":"29","author":"M Hashizume","year":"2009","journal-title":"Rheumatol Int"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0152341","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T05:56:06Z","timestamp":1540274166000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145468"}},"subtitle":[],"editor":[{"given":"Masataka","family":"Kuwana","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,23]]},"references-count":17,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145468","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0152341","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,23]]}}}