{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:08:55Z","timestamp":1790384935472,"version":"4.1.0"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145476","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T18:59:43Z","timestamp":1451501983000},"page":"e0145476","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma"],"prefix":"10.1371","volume":"10","author":[{"given":"Craig M.","family":"Riley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally E.","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil C.","family":"Erzurum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Fan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gaston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy C.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene R.","family":"Bleecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Calhoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar N.","family":"Jarjour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Busse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Gerald","family":"Teague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Sorkness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Holguin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"ref1","article-title":"National Heart, Lung and Blood Institute Produced Publications","year":"2007"},{"key":"ref2","first-page":"199","article-title":"Forced mid-expiratory flow rate (FEF 25\u201375%): a critical analysis of its value in recognizing diseases of the small airways","volume":"14","author":"M Terra Filho","year":"1986","journal-title":"Allergol Immunopathol (Madr)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.rmed.2013.08.009","article-title":"Small airway impairment in moderate to severe asthmatics without significant proximal airway obstruction","volume":"107","author":"T Perez","year":"2013","journal-title":"Respir Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0002-9343(72)90078-2","article-title":"A reduction in maximum mid-expiratory flow rate. A spirographic manifestation of small airway disease","volume":"52","author":"ER McFadden Jr","year":"1972","journal-title":"Am J Med"},{"key":"ref5","unstructured":"(2007) Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10900-006-9026-4","article-title":"Relationship between asthma, overweight, and physical activity among U.S. high school students","volume":"31","author":"SE Jones","year":"2006","journal-title":"J Community Health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1183\/09031936.00128113","article-title":"Measurement of FEF25-75% and FEF75% does not contribute to clinical decision making","volume":"43","author":"PH Quanjer","year":"2014","journal-title":"Eur Respir J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/02770903.2012.690481","article-title":"The utility of forced expiratory flow between 25% and 75% of vital capacity in predicting childhood asthma morbidity and severity","volume":"49","author":"DR Rao","year":"2012","journal-title":"J Asthma"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1164\/rccm.201107-1317PP","article-title":"Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program","volume":"185","author":"NN Jarjour","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1164\/ajrccm\/136.5.1285","article-title":"Standardization of spirometry\u20141987 update. Statement of the American Thoracic Society","volume":"136","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general U.S. population","volume":"159","author":"JL Hankinson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","author":"S American Thoracic","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1152\/japplphysiol.00329.2007","article-title":"Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation","volume":"104","author":"RL Sorkness","year":"2008","journal-title":"J Appl Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1164\/ajrccm\/137.2.493c","article-title":"Standardization of spirometry","volume":"137","author":"JL Hankinson","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"ref15","first-page":"272","article-title":"Standardization of spirometry\u20141987 ATS update (American Thoracic Society)","volume":"30","author":"RM Gardner","year":"1988","journal-title":"J Occup Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jaci.2004.03.016","article-title":"Physiologic correlates of distal lung inflammation in asthma","volume":"113","author":"ER Sutherland","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1164\/ajrccm.162.4.9909044","article-title":"Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices","volume":"162","author":"A Niimi","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/02770903.2012.690481","article-title":"The utility of forced expiratory flow between 25% and 75% of vital capacity in predicting childhood asthma morbidity and severity","volume":"49","author":"DR Rao","year":"2012","journal-title":"J Asthma"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1164\/rccm.200905-0695OC","article-title":"Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma","volume":"181","author":"RA Dweik","year":"2010","journal-title":"Am J Respir Crit Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T02:39:29Z","timestamp":1567478369000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145476"}},"subtitle":[],"editor":[{"given":"Heinz","family":"Fehrenbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145476","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,30]]}}}