{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:57:44Z","timestamp":1780606664186,"version":"3.54.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145513","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T18:39:16Z","timestamp":1452710356000},"page":"e0145513","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Novel Endothelial Cell-Specific AQP1 Knockout Mice Confirm the Crucial Role of Endothelial AQP1 in Ultrafiltration during Peritoneal Dialysis"],"prefix":"10.1371","volume":"11","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Freichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van der Hoeven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Paul","family":"Nawroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"K\u00e4lble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Zitron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Schwenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.semnephrol.2011.01.006","article-title":"Determinants of peritoneal membrane function over time","volume":"31","author":"SJ Davies","year":"2011","journal-title":"Semin Nephrol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/ki.2013.250","article-title":"Water transport across the peritoneal membrane","volume":"85","author":"O Devuyst","year":"2014","journal-title":"Kidney Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/sj.ki.5000285","article-title":"Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis","volume":"69","author":"J Ni","year":"2006","journal-title":"Kidney Int"},{"key":"ref4","first-page":"H2254","article-title":"In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats","volume":"271","author":"O Carlsson","year":"1996","journal-title":"Am J Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1681\/ASN.V10102185","article-title":"Regulation of aquaporin-1 and nitric oxide synthase isoforms in a rat model of acute peritonitis","volume":"10","author":"S Combet","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/BC20040132","article-title":"Aquaporin-1 in the peritoneal membrane: implications for peritoneal dialysis and endothelial cell function","volume":"97","author":"O Devuyst","year":"2005","journal-title":"Biol Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1111\/j.1523-1755.2005.00304.x","article-title":"Functional and molecular characterization of a peritoneal dialysis model in the c57bl\/6j mouse","volume":"67","author":"J Ni","year":"2005","journal-title":"Kidney Int"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00424-007-0402-4","article-title":"Clinical application of aquaporin research: aquaporin-1 in the peritoneal membrane","volume":"456","author":"T Nishino","year":"2008","journal-title":"Pflugers Arch"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"C76","DOI":"10.1152\/ajpcell.1999.276.1.C76","article-title":"Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice","volume":"276","author":"B Yang","year":"1999","journal-title":"Am J Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.mam.2012.06.001","article-title":"The first discovered water channel protein, later called aquaporin 1: Molecular characteristics, functions and medical implications","volume":"33","author":"G Benga","year":"2012","journal-title":"Molecular aspects of medicine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1681\/ASN.V1251036","article-title":"Expression of aquaporin-1 in human peritoneal mesothelial cells and its upregulation by glucose in vitro","volume":"12","author":"KN Lai","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00467-012-2120-1","article-title":"Buffer-dependent regulation of aquaporin-1 expression and function in human peritoneal mesothelial cells","volume":"27","author":"Y Zhai","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"C1744","DOI":"10.1152\/ajpcell.2000.279.6.C1744","article-title":"Role of aquaporin water channels in pleural fluid dynamics","volume":"279","author":"Y Song","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/01902148.2013.859333","article-title":"Down-regulation of Aquaporin1 (AQP1) by peptidoglycan via p38 MAPK pathways in primary rat pleural mesothelial cells","volume":"40","author":"L Liu","year":"2014","journal-title":"Exp Lung Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0014-5793(98)01272-1","article-title":"Transgenic Cre recombinase expression in germ cells and early embryogenesis directs homogeneous and ubiquitous deletion of loxP-flanked gene segments","volume":"438","author":"I Bergqvist","year":"1998","journal-title":"FEBS Letters"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1074\/jbc.273.8.4296","article-title":"Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels","volume":"273","author":"T Ma","year":"1998","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1681\/ASN.V1051126","article-title":"Lessons on renal physiology from transgenic mice lacking aquaporin water channels","volume":"10","author":"AS Verkman","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2156-9-4","article-title":"Reduced body weight is a common effect of gene knockout in mice","volume":"9","author":"DR Reed","year":"2008","journal-title":"BMC Genetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ki.1989.115","article-title":"Simulation of peritoneal solute transport during CAPD. Application of two-pore formalism","volume":"35","author":"B Rippe","year":"1989","journal-title":"Kidney Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/ki.1991.216","article-title":"Computer simulations of peritoneal fluid transport in CAPD","volume":"40","author":"B Rippe","year":"1991","journal-title":"Kidney Int"},{"issue":"Suppl 2","key":"ref21","first-page":"S35","article-title":"A three-pore model of peritoneal transport","volume":"13","author":"B Rippe","year":"2000","journal-title":"Perit Dial Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/089686080402400102","article-title":"Fluid and electrolyte transport across the peritoneal membrane during CAPD according to the three-pore model","volume":"24","author":"B Rippe","year":"2004","journal-title":"Perit Dial Int"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1523-1755.2005.00465.x","article-title":"Mini-peritoneal equilibration test: A simple and fast method to assess free water and small solute transport across the peritoneal membrane","volume":"68","author":"V La Milia","year":"2005","journal-title":"Kidney Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00467-013-2447-2","article-title":"The mini-PET in pediatric peritoneal dialysis: a useful tool to predict volume overload?","volume":"28","author":"F Cano","year":"2013","journal-title":"Pediatr Nephrol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1523-1755.2004.00815.x","article-title":"Quantification of free water transport in peritoneal dialysis","volume":"66","author":"W Smit","year":"2004","journal-title":"Kidney Int"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physrev.00024.2001","article-title":"Aquaporins in the kidney: from molecules to medicine","volume":"82","author":"S Nielsen","year":"2002","journal-title":"Physiol Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature09002","article-title":"Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis","volume":"465","author":"Y Wang","year":"2010","journal-title":"Nature"},{"key":"ref28","first-page":"6","article-title":"Correction of sodium sieving for diffusion from the circulation","volume":"19","author":"W Westra","year":"2003","journal-title":"Adv Perit Dial"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1161\/01.ATV.17.8.1599","article-title":"A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants","volume":"17","author":"QG Dong","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1549-8719.2011.00128.x","article-title":"An improved and reliable method for isolation of microvascular endothelial cells from human omentum","volume":"18","author":"BK Winiarski","year":"2011","journal-title":"Microcirculation"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T14:43:27Z","timestamp":1654094607000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145513"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,13]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145513","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,13]]}}}