{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:10:48Z","timestamp":1754395848392},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145581","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T18:37:56Z","timestamp":1450723076000},"page":"e0145581","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations of Polymorphisms in MTHFR Gene with the Risk of Age-Related Cataract in Chinese Han Population: A Genotype-Phenotype Analysis"],"prefix":"10.1371","volume":"10","author":[{"given":"Xue-bin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-di","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning-hua","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu-liang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu-hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"D Pascolini","year":"2012","journal-title":"Br J Ophthalmol"},{"issue":"9459","key":"ref2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0140-6736(05)70803-5","article-title":"Age-related cataract","volume":"365","author":"PA Asbell","year":"2005","journal-title":"Lancet"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.bbadis.2009.06.011","article-title":"A novel mutation (F71L) in alphaA-crystallin with defective chaperone-like function associated with age-related cataract","volume":"1792","author":"SG Bhagyalaxmi","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1089\/ars.2008.2119","article-title":"Oxidative stress, lens gap junctions, and cataracts","volume":"11","author":"VM Berthoud","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1755-3768.2009.01583.x","article-title":"Oxidative DNA damage in patients with cataract","volume":"88","author":"O Ates","year":"2010","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2012.08.017","article-title":"Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection","volume":"200","author":"R Elanchezhian","year":"2012","journal-title":"Chem Biol Interact"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1161\/CIRCRESAHA.112.269472","article-title":"Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr\/CBS-deficient mice","volume":"111","author":"D Zhang","year":"2012","journal-title":"Circ Res"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.yjmcc.2011.12.009","article-title":"Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress","volume":"52","author":"X Wang","year":"2012","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1743-7075-11-55","article-title":"Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes","volume":"11","author":"X Luo","year":"2014","journal-title":"Nutr Metab (Lond)"},{"issue":"22","key":"ref10","doi-asserted-by":"crossref","first-page":"12503","DOI":"10.1073\/pnas.231428998","article-title":"Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction","volume":"98","author":"N Weiss","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1167\/iovs.14-15531","article-title":"Serum homocysteine, vitamin B12, and folate, and the prevalence and incidence of posterior subcapsular cataract","volume":"56","author":"AG Tan","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12291-008-0057-8","article-title":"Plasma Homocysteine, Folate and Vitamin B(12) levels in senile cataract","volume":"23","author":"SK Sen","year":"2008","journal-title":"Indian J Clin Biochem"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"e563","DOI":"10.1097\/MD.0000000000000563","article-title":"Relationship of MTHFR gene 677C \u2014> T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes","volume":"94","author":"X Qin","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1055\/s-0038-1657581","article-title":"Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR)","volume":"78","author":"R Rozen","year":"1997","journal-title":"Thromb Haemost"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"NM van der Put","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ophtha.2009.11.023","article-title":"Prevalence of vision impairment in older adults in rural China: the China Nine-Province Survey","volume":"117","author":"J Zhao","year":"2010","journal-title":"Ophthalmology"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/archopht.1993.01090060119035","article-title":"The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group","volume":"111","author":"LT Chylack Jr","year":"1993","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"ref18","first-page":"2138","article-title":"Senile cataract progression studies using the Lens Opacities Classification System II","volume":"34","author":"BV Magno","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1167\/iovs.12-9820","article-title":"Smoking and risk of age-related cataract: a meta-analysis","volume":"53","author":"J Ye","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref20","article-title":"Different Amounts of Alcohol Consumption and Cataract: A Meta-analysis","author":"Y Gong","year":"2015","journal-title":"Optom Vis Sci"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"e114012","DOI":"10.1371\/journal.pone.0114012","article-title":"Hypertension and risk of cataract: a meta-analysis","volume":"9","author":"X Yu","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1167\/iovs.13-13695","article-title":"Association between dietary carbohydrate intake and dietary glycemic index and risk of age-related cataract: a meta-analysis","volume":"55","author":"H Wu","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Web Server issue","key":"ref23","doi-asserted-by":"crossref","first-page":"W600","DOI":"10.1093\/nar\/gkp290","article-title":"SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies","volume":"37","author":"Z Xu","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1373\/clinchem.2004.032136","article-title":"Genotyping of single-nucleotide polymorphisms by high-resolution melting of small amplicons","volume":"50","author":"M Liew","year":"2004","journal-title":"Clin Chem"},{"issue":"6 Pt 1","key":"ref25","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1373\/49.6.1029","article-title":"Automated enzymatic assay for homocysteine","volume":"49","author":"Y Tan","year":"2003","journal-title":"Clin Chem"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1086\/338688","article-title":"Score tests for association between traits and haplotypes when linkage phase is ambiguous","volume":"70","author":"DJ Schaid","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"e0123423","DOI":"10.1371\/journal.pone.0123423","article-title":"Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case-control studies involving 35,758 individuals","volume":"10","author":"D Zhang","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/bjd.12845","article-title":"Genetic polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study","volume":"170","author":"JX Chen","year":"2014","journal-title":"Br J Dermatol"},{"issue":"16","key":"ref29","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1001\/jama.288.16.2023","article-title":"MTHFR 677C\u2014>T polymorphism and risk of coronary heart disease: a meta-analysis","volume":"288","author":"M Klerk","year":"2002","journal-title":"Jama"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1160\/TH15-02-0096","article-title":"Gene polymorphisms as risk factors for predicting the cardiovascular manifestations in Marfan syndrome. Role of folic acid metabolism enzyme gene polymorphisms in Marfan syndrome","volume":"114","author":"K Benke","year":"2015","journal-title":"Thromb Haemost"},{"issue":"9791","key":"ref31","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0140-6736(11)60872-6","article-title":"Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials","volume":"378","author":"MV Holmes","year":"2011","journal-title":"Lancet"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1161\/STROKEAHA.114.005208","article-title":"Effect of genetic variants associated with plasma homocysteine levels on stroke risk","volume":"45","author":"I Cotlarciuc","year":"2014","journal-title":"Stroke"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"10585","DOI":"10.1038\/srep10585","article-title":"Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis","volume":"5","author":"P Huang","year":"2015","journal-title":"Sci Rep"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.ophtha.2009.02.033","article-title":"Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: a meta-analysis","volume":"116","author":"SJ McGimpsey","year":"2009","journal-title":"Ophthalmology"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.ophtha.2012.06.025","article-title":"Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis","volume":"119","author":"F Xu","year":"2012","journal-title":"Ophthalmology"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood.V94.3.959.415k20_959_967","article-title":"Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells","volume":"94","author":"PA Outinen","year":"1999","journal-title":"Blood"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/MIB.0000000000000238","article-title":"Endoplasmic reticulum stress and unfolded protein response in inflammatory bowel disease","volume":"21","author":"SS Cao","year":"2015","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.exer.2006.01.033","article-title":"Role of the unfolded protein response (UPR) in cataract formation","volume":"83","author":"K Ikesugi","year":"2006","journal-title":"Exp Eye Res"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.molcel.2004.08.025","article-title":"Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death","volume":"15","author":"CM Haynes","year":"2004","journal-title":"Mol Cell"},{"issue":"15","key":"ref40","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1021\/bi052294c","article-title":"Structural perturbations in the Ala\u2014> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation","volume":"45","author":"R Pejchal","year":"2006","journal-title":"Biochemistry"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"PF Jacques","year":"1996","journal-title":"Circulation"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.exer.2004.12.007","article-title":"Age-related nuclear cataract-oxidation is the key","volume":"80","author":"RJ Truscott","year":"2005","journal-title":"Exp Eye Res"},{"issue":"1","key":"ref43","first-page":"227","article-title":"Evidence for a major gene for cortical cataract","volume":"36","author":"IM Heiba","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"ref44","first-page":"601","article-title":"The heritability of age-related cortical cataract: the twin eye study","volume":"42","author":"CJ Hammond","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ophtha.2004.07.012","article-title":"Cortical, but not posterior subcapsular, cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors","volume":"112","author":"N Congdon","year":"2005","journal-title":"Ophthalmology"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/gb-2008-9-2-208","article-title":"Intron mis-splicing: no alternative?","volume":"9","author":"SW Roy","year":"2008","journal-title":"Genome Biol"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tig.2011.01.001","article-title":"Genome-wide transcription factor binding: beyond direct target regulation","volume":"27","author":"KL MacQuarrie","year":"2011","journal-title":"Trends Genet"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"HJ Westra","year":"2013","journal-title":"Nat Genet"},{"issue":"23","key":"ref49","doi-asserted-by":"crossref","first-page":"8055","DOI":"10.1073\/pnas.0802813105","article-title":"The prevalence of folate-remedial MTHFR enzyme variants in humans","volume":"105","author":"NJ Marini","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","article-title":"Insights into Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency: Molecular Genetic and Enzymatic Characterization of 76 Patients","author":"P Burda","year":"2015","journal-title":"Hum Mutat"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0021-9150(00)00671-7","article-title":"The 1298A\u2014>C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine","volume":"156","author":"IS Weisberg","year":"2001","journal-title":"Atherosclerosis"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ajo.2005.05.026","article-title":"Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract","volume":"140","author":"M Zetterberg","year":"2005","journal-title":"Am J Ophthalmol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T02:00:22Z","timestamp":1599962422000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145581"}},"subtitle":[],"editor":[{"given":"Xu-jie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":52,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145581","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]}}}