{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:22:55Z","timestamp":1759530175563},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145766","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T13:48:48Z","timestamp":1451310528000},"page":"e0145766","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phosphodiesterase 5a Inhibition with Adenoviral Short Hairpin RNA Benefits Infarcted Heart Partially through Activation of Akt Signaling Pathway and Reduction of Inflammatory Cytokines"],"prefix":"10.1371","volume":"10","author":[{"given":"Longhu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"14A","DOI":"10.1016\/0735-1097(93)90456-B","article-title":"Natural history and patterns of current practice in heart failure. The Studies of Left Ventricular Dysfunction (SOLVD) Investigators","volume":"22","author":"MG Bourassa","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/CIRCULATIONAHA.106.623199","article-title":"Navigating the crossroads of coronary artery disease and heart failure","volume":"114","author":"M Gheorghiade","year":"2006","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/CIRCRESAHA.107.162511","article-title":"Phosphodiesterase type 5: expanding roles in cardiovascular regulation","volume":"101","author":"DA Kass","year":"2007","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/pr.58.3.5","article-title":"Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use","volume":"58","author":"AT Bender","year":"2006","journal-title":"Pharmacol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.0000256354.95791.f1","article-title":"Overview of PDEs and their regulation","volume":"100","author":"K Omori","year":"2007","journal-title":"Circ Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/thx.2005.041954","article-title":"Phosphodiesterase type 5 and high altitude pulmonary hypertension","volume":"60","author":"AA Aldashev","year":"2005","journal-title":"Thorax"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/CIRCULATIONAHA.108.822072","article-title":"Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice","volume":"119","author":"P Pokreisz","year":"2009","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.4155\/fmc.13.127","article-title":"Therapeutic potential of PDE modulation in treating heart disease","volume":"5","author":"W Knight","year":"2013","journal-title":"Future Med Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.2174\/092986707781389619","article-title":"The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development","volume":"14","author":"M Guazzi","year":"2007","journal-title":"Curr Med Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11897-012-0121-9","article-title":"Role of phosphodiesterase-5 inhibitors in heart failure: emerging data and concepts","volume":"10","author":"M Kanwar","year":"2013","journal-title":"Curr Heart Fail Rep"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"H2112","DOI":"10.1152\/ajpheart.00339.2011","article-title":"Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction","volume":"302","author":"L Li","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0735-1097(96)00268-9","article-title":"Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension","volume":"28","author":"M Testa","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0735-1097(95)00589-7","article-title":"Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction a report from the Studies of LeftVentricular Dysfunction (SOLVD)","volume":"27","author":"G Torre-Amione","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.CIR.98.2.149","article-title":"Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodeling","volume":"98","author":"K Ono","year":"1998","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17204","DOI":"10.3390\/ijms151017204","article-title":"Sildenafil attenuates inflammation and oxidative stress in pelvic Ganglia neurons after bilateral cavernosal nerve damage","volume":"15","author":"LA Garcia","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"H1504","DOI":"10.1152\/ajpheart.00194.2009","article-title":"Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction","volume":"297","author":"L Li","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/01.RES.79.1.79","article-title":"Developmental changes in the delayed rectifier K+ channels in mouse heart","volume":"79","author":"L Wang","year":"1996","journal-title":"Circ Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/01.RES.0000225952.61196.39","article-title":"Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling","volume":"98","author":"R Uemura","year":"2006","journal-title":"Circ Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13G","DOI":"10.1016\/0002-9149(93)90102-I","article-title":"Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models","volume":"72","author":"KA Reimer","year":"1993","journal-title":"Am J Cardiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications","volume":"81","author":"MA Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/978-3-540-68964-5_21","article-title":"Modulation of cGMP in heart failure: a new therapeutic paradigm","volume":"191","author":"G Boerrigter","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"32831","DOI":"10.1074\/jbc.M603416200","article-title":"cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes","volume":"281","author":"B Fiedler","year":"2006","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nm1175","article-title":"Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy","volume":"11","author":"E Takimoto","year":"2005","journal-title":"Nat Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1093\/nar\/gnh129","article-title":"Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo","volume":"32","author":"D Gou","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/01.RES.64.6.1041","article-title":"Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle","volume":"64","author":"JE Jalil","year":"1989","journal-title":"Circ Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/oxfordjournals.eurheartj.a015268","article-title":"Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure","volume":"18","author":"B Devaux","year":"1997","journal-title":"Eur Heart J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1161\/01.CIR.103.16.2055","article-title":"Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST)","volume":"103","author":"A Deswal","year":"2001","journal-title":"Circulation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.RES.0000043825.01705.1B","article-title":"Inflammatory mediators and the failing heart: past, present, and the foreseeable future","volume":"91","author":"DL Mann","year":"2002","journal-title":"Circ Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1023\/A:1011462011567","article-title":"The role of anti-cytokine therapy in the failing heart","volume":"6","author":"A Deswal","year":"2001","journal-title":"Heart Fail Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.cellsig.2013.08.001","article-title":"Nitric oxide regulates AKT phosphorylation and nuclear translocation in cultured retinal cells","volume":"25","author":"TA Mej\u00eda-Garc\u00eda","year":"2013","journal-title":"Cell Signal"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuint.2006.08.007","article-title":"Bone marrow stromal cells mediate protection through stimulation of PI3-K\/Akt and MAPK signaling in neurons","volume":"50","author":"NB Isele","year":"2007","journal-title":"Neurochem Int"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbrc.2012.04.147","article-title":"Effect of 710 nm visible light irradiation on neurite outgrowth in primary rat cortical neurons following ischemic insult","volume":"422","author":"DH Choi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4196\/kjpp.2010.14.1.37","article-title":"Inhibition of eNOS\/sGC\/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse Hippocampus","volume":"14","author":"SH Lee","year":"2010","journal-title":"Korean J Physiol Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T08:51:33Z","timestamp":1540025493000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145766"}},"subtitle":[],"editor":[{"given":"Yaoliang","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,28]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145766","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,28]]}}}