{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:48:10Z","timestamp":1783075690390,"version":"3.54.6"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:00:00Z","timestamp":1451952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145807","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T19:00:39Z","timestamp":1452020439000},"page":"e0145807","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Tenascin-C, a Prognostic Determinant of Esophageal Squamous Cell Carcinoma"],"prefix":"10.1371","volume":"11","author":[{"given":"Zhao-Ting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Young","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Xue","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hua","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"J CA Cancer Clin"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1247\/csf.26.179","article-title":"Tenascin-C splice variant adhesive\/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin","volume":"26","author":"MA Ghert","year":"2001","journal-title":"J Cell Struct Funct"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.canlet.2006.02.017","article-title":"Tenascin-C induced signaling in cancer","volume":"244","author":"G Orend","year":"2006","journal-title":"J Cancer Lett"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1582-4934.2011.01360.x","article-title":"How do tenascins influence the birth and life of a malignant cell","volume":"16","author":"F Brellier","year":"2012","journal-title":"J Cell Mol Med"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/path.1415","article-title":"Tenascins: regulation and putative functions during pathological stress","volume":"200","author":"R Chiquet-Ehrismann","year":"2003","journal-title":"J Pathol"},{"issue":"6","key":"ref6","first-page":"1","article-title":"The prognostic significance of cancer-associated fibroblasts in esophageal squamous cell carcinoma","volume":"9","author":"SY Ha","year":"2014","journal-title":"PLoS One"},{"key":"ref7","first-page":"291","article-title":"Quantification of histochemical staining by color deconvolution","volume":"23","author":"AC Ruifrok","year":"2001","journal-title":"Anal Quant Cytol Histol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.50.10.801","article-title":"A scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group","volume":"50","author":"P J van Diest","year":"1997","journal-title":"J Clin Pathol"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"23303","DOI":"10.1371\/journal.pone.0023303","article-title":"Including Total EGFR Staining in Scoring Improves EGFR Mutations Detection by Mutation-Specific Antibodies and EGFR TKIs Response Prediction","volume":"6","author":"Shang-Gin Wu","year":"2011","journal-title":"PLos One"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"96801","DOI":"10.1371\/journal.pone.0096801","article-title":"IHC Profiler: An Open Source Plugin for the Quantitative Evaluation and Automated Scoring of Immunohistochemistry Images of Human Tissue Samples","volume":"9","author":"F Varghese","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<475::AID-PATH462>3.0.CO;2-V","article-title":"Synthesis and protein distribution of the unspliced large tenascin-C isoform in oral squamous cell carcinoma","volume":"189","author":"W Hindermann","year":"1999","journal-title":"J Pathol"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0002-9440(10)64320-9","article-title":"Involvement of large tenascin-C splice variants in breast cancer progression","volume":"162","author":"T Tsunoda","year":"2003","journal-title":"Am J Pathol"},{"issue":"2","key":"ref13","first-page":"782","article-title":"Tenascin-C expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients and the inflammatory cytokine TNF-\u03b1-induced TNC expression promotes migration in HCC cells","volume":"5","author":"Y Nong","year":"2015","journal-title":"J Am Cancer Res"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.lungcan.2004.05.016","article-title":"Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes","volume":"47","author":"K Parekh","year":"2005","journal-title":"J Lung Cancer"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm.2379","article-title":"Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs","volume":"17","author":"T Oskarsson","year":"2011","journal-title":"Nat Med"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1007\/s13277-014-1875-3","article-title":"Clinical significance of serum tenascin-C levels in breast cancer","volume":"35","author":"D Tastekin","year":"2014","journal-title":"J Tumour Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-4419-8997-0_8","article-title":"Hypoxia and lung branching morphogenesis","volume":"543","author":"SA Gebb","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1158\/0008-5472.CAN-08-2724","article-title":"Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts","volume":"69","author":"C Anderberg","year":"2009","journal-title":"Cancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.4161\/cbt.5.12.3354","article-title":"Identification of fibroblast heterogeneity in the tumormicroenvironment","volume":"5","author":"H Sugimoto","year":"2006","journal-title":"J Cancer Biol Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2353\/ajpath.2009.081030","article-title":"Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer","volume":"175","author":"J Paulsson","year":"2009","journal-title":"Am Pathol"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1245\/s10434-014-4149-9","article-title":"Histologic categorization of desmoplastic reaction: its relevance to the colorectal cancer microenvironment and prognosis","volume":"22","author":"H Ueno","year":"2015","journal-title":"Ann Surg Oncol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T05:58:09Z","timestamp":1540274289000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145807"}},"subtitle":[],"editor":[{"given":"Yves","family":"St-Pierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,5]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145807","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,5]]}}}