{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:10:21Z","timestamp":1782277821183,"version":"3.54.5"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145815","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T13:46:31Z","timestamp":1451396791000},"page":"e0145815","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association of Common Variants in LOX with Keratoconus: A Meta-Analysis"],"prefix":"10.1371","volume":"10","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"issue":"4","key":"ref1","first-page":"297","article-title":"Keratoconus. Survey of ophthalmology","volume":"42","author":"YS Rabinowitz","year":"1998","journal-title":"Keratoconus. Survey of ophthalmology"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ajo.2009.06.024","article-title":"Prevalence and associations of keratoconus in rural maharashtra in central India: the central India eye and medical study","volume":"148","author":"JB Jonas","year":"2009","journal-title":"American journal of ophthalmology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.eye.6700652","article-title":"Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asians and white patients","volume":"18","author":"T Georgiou","year":"2004","journal-title":"Eye"},{"issue":"Pt 4","key":"ref4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/eye.2000.154","article-title":"Does ethnic origin influence the incidence or severity of keratoconus?","volume":"14","author":"AR Pearson","year":"2000","journal-title":"Eye"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"e482","DOI":"10.1111\/j.1755-3768.2012.02448.x","article-title":"Keratoconus in 18 pairs of twins","volume":"90","author":"SJ Tuft","year":"2012","journal-title":"Acta ophthalmologica"},{"issue":"5\u20136","key":"ref6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/08820538.2013.825295","article-title":"The genetics of keratoconus","volume":"28","author":"HY Chang","year":"2013","journal-title":"Seminars in ophthalmology"},{"key":"ref7","first-page":"641708","article-title":"Genetics of keratoconus: where do we stand?","volume":"2014","author":"KK Abu-Amero","year":"2014","journal-title":"Journal of ophthalmology"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1167\/iovs.08-2382","article-title":"Linkage analysis in keratoconus: replication of locus 5q21.2 and identification of other suggestive","volume":"50","author":"L Bisceglia","year":"2009","journal-title":"Loci. Investigative ophthalmology & visual science"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/hmg\/11.9.1029","article-title":"VSX1: a gene for posterior polymorphous dystrophy and keratoconus","volume":"11","author":"E Heon","year":"2002","journal-title":"Human molecular genetics"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1167\/iovs.05-1500","article-title":"SOD1: a candidate gene for keratoconus","volume":"47","author":"N Udar","year":"2006","journal-title":"Investigative ophthalmology & visual science"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.gene.2012.04.061","article-title":"The point mutation and polymorphism in keratoconus candidate gene TGFBI in Chinese population","volume":"503","author":"T Guan","year":"2012","journal-title":"Gene"},{"key":"ref12","first-page":"2848","article-title":"Polymorphisms in COL4A3 and COL4A4 genes associated with keratoconus","volume":"15","author":"M Stabuc-Silih","year":"2009","journal-title":"Molecular vision"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/13816810.2012.743569","article-title":"Common single nucleotide polymorphisms and keratoconus in the Han Chinese population","volume":"34","author":"Y Wang","year":"2013","journal-title":"Ophthalmic genetics"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1167\/iovs.11-9268","article-title":"Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies","volume":"53","author":"Y Bykhovskaya","year":"2012","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref15","article-title":"Validation of rs2956540:G&gt;C and rs3735520:G&gt;A association with keratoconus in a population of European descent","author":"L Dudakova","year":"2015","journal-title":"European journal of human genetics: EJHG"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/13816810.2015.1005317","article-title":"Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population","volume":"36","author":"XD Hao","year":"2015","journal-title":"Ophthalmic genetics"},{"key":"ref17","article-title":"Association of Lysyl oxidase (LOX) polymorphisms with the risk of Keratoconus in an Iranian population","author":"F Hasanian-Langroudi","year":"2014","journal-title":"Ophthalmic genetics"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"e109142","DOI":"10.1371\/journal.pone.0109142","article-title":"Association of common variants in TCF4 and PTPRG with Fuchs&apos; corneal dystrophy: a systematic review and meta-analysis","volume":"9","author":"LC Lau","year":"2014","journal-title":"PloS one"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.7326\/0003-4819-127-9-199711010-00008","article-title":"Quantitative synthesis in systematic reviews","volume":"127","author":"J Lau","year":"1997","journal-title":"Annals of internal medicine"},{"issue":"7109","key":"ref20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"Bmj"},{"issue":"20","key":"ref21","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1002\/sim.2380","article-title":"A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints","volume":"25","author":"RM Harbord","year":"2006","journal-title":"Statistics in medicine"},{"issue":"24","key":"ref22","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","article-title":"SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap","volume":"24","author":"AD Johnson","year":"2008","journal-title":"Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.exer.2012.09.005","article-title":"Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas","volume":"104","author":"L Dudakova","year":"2012","journal-title":"Experimental eye research"},{"key":"ref24","first-page":"12","article-title":"Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity","volume":"21","author":"R Shetty","year":"2015","journal-title":"Molecular vision"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T22:34:53Z","timestamp":1540247693000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145815"}},"subtitle":[],"editor":[{"given":"Michele","family":"Madigan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145815","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]}}}