{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:33:40Z","timestamp":1790332420117,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145908","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T19:06:10Z","timestamp":1452539170000},"page":"e0145908","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Two-Dimensional Differential Gel Electrophoresis to Identify Protein Biomarkers in Amniotic Fluid of Edwards Syndrome (Trisomy 18) Pregnancies"],"prefix":"10.1371","volume":"11","author":[{"given":"Te-Yao","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Ning","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuender D.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Hsin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hai","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Hua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsun","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An Kuo","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Chun","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/0969141314543128","article-title":"Antenatal detection of Edwards (Trisomy 18) and Patau (Trisomy 13) syndrome: England and Wales 2005\u20132012","volume":"21","author":"AL Springett","year":"2014","journal-title":"J Med Screen"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1002\/ajmg.a.36127","article-title":"Survival of trisomy 18 (Edwards syndrome) and trisomy 13 (Patau Syndrome) in England and Wales: 2004\u20132011","volume":"161A","author":"J Wu","year":"2013","journal-title":"Am J Med Genet A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1750-1172-7-81","article-title":"The trisomy 18 syndrome","volume":"7","author":"A Cereda","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/pmic.200300654","article-title":"Proteomic determination of metabolic enzymes of the amnion cell: basis for a possible diagnostic tool","volume":"4","author":"J Oh","year":"2004","journal-title":"Proteomics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1002\/pmic.200600085","article-title":"Proteomic analysis of amniotic fluid in pregnancies with Down syndrome","volume":"6","author":"GT Tsangaris","year":"2006","journal-title":"Proteomics"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dmm.013391","article-title":"Aneuploidy: implications for protein homeostasis and disease","volume":"7","author":"AB Oromendia","year":"2014","journal-title":"Dis Model Mech"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.3390\/ijms160510952","article-title":"Mass Spectrometry-Based Proteomics for Pre-Eclampsia and Preterm Birth","volume":"16","author":"KP Law","year":"2015","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/elps.200390189","article-title":"Reversed-phase high-performance liquid chromatography prefractionation prior to two-dimensional difference gel electrophoresis and mass spectrometry identifies new differentially expressed proteins between striate cortex of kitten and adult cat","volume":"24","author":"G Van den Bergh","year":"2003","journal-title":"Electrophoresis"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"e68318","DOI":"10.1371\/journal.pone.0068318","article-title":"Altered protein networks and cellular pathways in severe west nile disease in mice","volume":"8","author":"C Fraisier","year":"2013","journal-title":"PLOS One"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/dmrr.2419","article-title":"Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis","volume":"29","author":"C Hern\u00e1ndez","year":"2013","journal-title":"Diabetes Metab Res Rev"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"3","key":"ref12","first-page":"290","article-title":"Health and disease in adults with Down syndrome","volume":"133","author":"EA Malt","year":"2013","journal-title":"Tidsskr Nor Laegeforen"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.fertnstert.2008.05.038","article-title":"Network analyses of differentially expressed proteins in amniotic fluid supernatant associated with abnormal human karyotypes","volume":"92","author":"TH Wang","year":"2009","journal-title":"Fertil Steril"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nrd2353","article-title":"Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery","volume":"7","author":"KM Wasan","year":"2008","journal-title":"Nat Rev Drug Discov"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/sj.mp.4002108","article-title":"Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues","volume":"13","author":"JT Huang","year":"2008","journal-title":"Mol Psychiatry"},{"issue":"1\u20132","key":"ref16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/prca.201200087","article-title":"Apolipoprotein A-I: insights from redox proteomics for its role in neurodegeneration","volume":"7","author":"JT Keeney","year":"2013","journal-title":"Proteomics Clin Appl"},{"issue":"3\u20134","key":"ref17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/prca.201000121","article-title":"Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid","volume":"5","author":"M Perluigi","year":"2011","journal-title":"Proteomics Clin Appl"},{"issue":"6","key":"ref18","first-page":"801","article-title":"Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions","volume":"18","author":"S Rajaram","year":"1997","journal-title":"Endocr Rev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1203\/00006450-199103000-00001","article-title":"Serum insulin-like growth factors and insulin-like growth factor binding proteinsin the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation","volume":"29","author":"C Lassarre","year":"1991","journal-title":"Pediatr Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0378-3782(92)90105-P","article-title":"Insulin-like growth factor-I and insulin-like growth factor binding protein-1 in early human pregnancy","volume":"28","author":"NC Wathen","year":"1992","journal-title":"Early Hum Dev"},{"key":"ref21","first-page":"1249","article-title":"Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs) and proteolyzed IGBP-3 in embryonic cavities in early human pregnancy: their potential relevance to maternal-embryonic and fetal interactions","volume":"79","author":"LD Nonoshita","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/bdrc.10022","article-title":"Biology of insulin-like growth factors in development","volume":"69","author":"J Dupont","year":"2003","journal-title":"Birth Defects Res C Embryo Today"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(05)80085-6","article-title":"Role of insulin-like growth factors in embryonic and postnatal growth","volume":"75","author":"J Baker","year":"1993","journal-title":"Cell"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/uog.12365","article-title":"First-trimester crown-rump length and embryonic volume of aneuploid fetuses measured in virtual reality","volume":"41","author":"L Baken","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1210\/jcem.82.1.3661","article-title":"The maternal insulin-like growth factor (IGF) and IGF-binding protein response to trisomic pregnancy during the first trimester: a possible diagnostic tool for trisomy 18 pregnancies","volume":"82","author":"JP Miell","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/jn\/135.7.1667","article-title":"Insulin-Like Growth Factor II and Binding Proteins 1 and 3 from Second Trimester Human Amniotic Fluid Are Associated with Infant Birth Weight","volume":"135","author":"DK Tisi","year":"2005","journal-title":"J Nutr"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejogrb.2011.03.029","article-title":"Maternal serum IGF-I, IGFBP-1 and IGFBP-3 at 11\u201313 weeks in trisomy 21 and trisomy18 pregnancies","volume":"157","author":"S Sifakis","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"E967","DOI":"10.1152\/ajpendo.2000.278.6.E967","article-title":"Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities","volume":"278","author":"RC Baxter","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6A","key":"ref29","first-page":"3689","article-title":"Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity","volume":"25","author":"H Nagasawa","year":"2005","journal-title":"Anticancer Res"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nsb754","article-title":"A structural basis for the unique binding features of the human vitamin D-binding protein","volume":"9","author":"C Verboven","year":"2002","journal-title":"Nat Struct Biol"},{"issue":"5","key":"ref31","first-page":"1025","article-title":"A maternal serum screen for trisomy 18: an extension of maternal serum screening for Down syndrome","volume":"49","author":"AJ Staples","year":"1991","journal-title":"Am J Hum Genet"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ejhg.2008.186","article-title":"A new mutation in the AFP gene responsible for a total absence of alpha feto-protein on second trimester maternal serum screening for Down syndrome","volume":"17","author":"FM Petit","year":"2009","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jprot.2009.12.009","article-title":"Proteomic analysis of amniotic fluid in pregnancies with Klinefelter syndrome foetuses","volume":"73","author":"AK Anagnostopoulos","year":"2010","journal-title":"J Proteomics"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1212\/WNL.36.7.900","article-title":"Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award","volume":"36","author":"J Herbert","year":"1986","journal-title":"Neurology"},{"key":"ref35","article-title":"Protein Misfolding Diseases: Current and Emerging Principles and Therapies","author":"SR Zeldenrust","year":"2010"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1371\/journal.pmed.0030428","article-title":"Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis","volume":"3","author":"JT Huang","year":"2006","journal-title":"PLOS Med"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000292343","article-title":"Amniotic fluid prealbumin as a potential marker of fetal abnormalities","volume":"40","author":"D Lolis","year":"1995","journal-title":"Gynecol Obstet Invest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/pd.2040","article-title":"Application of proteomics for the identification of differentially expressed protein markers for Down syndrome in maternal plasma","volume":"28","author":"A Kolialexi","year":"2008","journal-title":"Prenat Diagn"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1021\/cr010170+","article-title":"Serpin structure, mechanism, and function","volume":"102","author":"PG Gettins","year":"2002","journal-title":"Chem Rev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.tjog.2014.01.007","article-title":"Proteomic profiling reveals \u03b11-antitrypsin, \u03b11-microglobulin, and clustering as preeclampsia-related serum proteins in pregnant women","volume":"54","author":"TY Hsu","year":"2015","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1080\/10715760701291647","article-title":"Indices of oxidative stress in pregnancy with fetal growth restriction","volume":"41","author":"A Karowicz-Bilinska","journal-title":"Free Radic Res2007"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejmg.2005.05.011","article-title":"Decreased cholesterol synthesis as a possible aetiological factor in mal-formations of Trisomy 18","volume":"49","author":"WW Lam","year":"2006","journal-title":"Eur J Med Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/pd.1970140403","article-title":"Abnormal immunological development in fetuses with trisomy 18","volume":"14","author":"G Makrydimas","year":"1994","journal-title":"Prenat Diagn"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1159\/000095663","article-title":"Prenatally diagnosable differences in the cellular immunity of fetuses with Down's and Edwards' syndrome","volume":"21","author":"Z Zizka","year":"2006","journal-title":"Fetal Diagn Ther"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1442-200X.2006.02286.x","article-title":"Trisomy 18 syndrome with congenital fibrotic change in the liver","volume":"48","author":"K Maruyama","year":"2006","journal-title":"Pediatr Int"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T18:57:13Z","timestamp":1718305033000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145908"}},"subtitle":[],"editor":[{"given":"Daniela Flavia","family":"Hozbor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145908","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,11]]}}}