{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:12:09Z","timestamp":1793481129067,"version":"4.5.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0145944","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T18:43:48Z","timestamp":1451501028000},"page":"e0145944","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT"],"prefix":"10.1371","volume":"10","author":[{"given":"Shuo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yide","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"issue":"9793","key":"ref1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: shaped by global drivers and local environments","volume":"378","author":"BA Swinburn","year":"2011","journal-title":"Lancet"},{"issue":"9492","key":"ref2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"DW Haslam","year":"2015","journal-title":"Lancet"},{"issue":"9945","key":"ref3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0140-6736(14)60892-8","article-title":"Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5 24 million","volume":"384","author":"K Bhaskaran","year":"2014","journal-title":"UK adults. Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/nyas.12020","article-title":"The genetics of human obesity","volume":"1281","author":"Qianghua Xia","year":"2013","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref5","first-page":"197","article-title":"Genes and Obesity","author":"Claude Bouckard","year":"2010","journal-title":"Genes and Obesity"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1093\/hmg\/ddu248","article-title":"Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index","volume":"23","author":"W Wen","year":"2014","journal-title":"Human Molecular Genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1741-7015-8-87","article-title":"Obesity related methylation changes in DNA of peripheral blood leukocytes","volume":"8","author":"X Wang","year":"2010","journal-title":"BMC Med"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4161\/epi.24506","article-title":"A genome-wide methylation study on obesity: Differential variability and differential methylation","author":"X Xu","year":"2013","journal-title":"Epigenetics"},{"issue":"9933","key":"ref9","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0140-6736(13)62674-4","article-title":"DNA methylation and body-mass index: a genome-wide analysis","volume":"383","author":"KJ Dick","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gene.2014.07.009","article-title":"Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity","volume":"548","author":"MS Alm\u00e9n","year":"2014","journal-title":"Gene"},{"issue":"15","key":"ref11","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1093\/hmg\/ddv161","article-title":"Epigenome-wide Association Study (EWAS) of BMI, BMI Change, and Waist Circumference in African American Adults Identifies Multiple Replicated Loci","volume":"24","author":"EW Demerath","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"3","key":"ref12","first-page":"310","article-title":"Association study of childhood obesity with eight genetic variants recently identified by genome-wide association studies","volume":"76","author":"XR Meng","year":"2014","journal-title":"Population Study"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/oby.2009.268","article-title":"Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals","volume":"18","author":"D Wang","year":"2010","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0895-3988(09)60013-1","article-title":"Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents","volume":"21","author":"HJ Wang","year":"2008","journal-title":"Biomed Environ Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"15785","DOI":"10.1073\/pnas.0507816102","article-title":"Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry","volume":"102","author":"M Ehrich","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-59745-522-0_16","article-title":"Mass spectrometric analysis of cytosine methylation by base-specific cleavage and primer extension methods","volume":"507","author":"D van den Boom","year":"2009","journal-title":"Methods Mol Biol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"e88013","DOI":"10.1371\/journal.pone.0088013","article-title":"Quantitative methylation level of the EPHX1 promoter in peripheral blood DNA is associated with polycystic ovary syndrome","volume":"9","author":"Q Sang","year":"2014","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/1471-2164-14-472","article-title":"Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies","volume":"14","author":"J He","year":"2013","journal-title":"BMC Genomics"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1868-7083-4-21","article-title":"DNA methylation of the IGF2\/H19 imprinting control region and adiposity distribution in young adults","volume":"4","author":"RC Huang","year":"2012","journal-title":"Clin Epigenetics"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1038\/emboj.2012.125","article-title":"The updated biology of hypoxia-inducible factor","volume":"31","author":"SN Greer","year":"2012","journal-title":"EMBO J"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.biocel.2010.04.008","article-title":"Hypoxia-inducible factor (HIF)-3\u03b1 is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2","volume":"42","author":"A Pasanen","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"issue":"23","key":"ref22","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1007\/s00018-011-0679-5","article-title":"Roles of the human hypoxia-inducible factor (HIF)-3avariants in the hypoxia response","volume":"68","author":"M Heikkil\u00e4","year":"2011","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.2337\/db15-0264","article-title":"DNA methylation variants at HIF3A locus, B vitamins intake, and long-term weight change: gene-diet interactions in two US cohorts","volume":"64","author":"T Huang","year":"2015","journal-title":"Diabetes"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1248\/bpb.32.1166","article-title":"Hypoxia-Inducible Factor-3aFunctions as an Accelerator of 3T3-L1 Adipose Differentiation","volume":"32","author":"M Hatanaka","year":"2009","journal-title":"Biol. Pharm. Bull"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbrc.2006.11.027","article-title":"Non-hypoxic induction of HIF-3aby 2-deoxy-D-glucose and insulin","volume":"352","author":"M Heidbreder","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"EG Giannini","year":"2005","journal-title":"CMAJ"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1572-0241.2003.07486.x","article-title":"The prevalence and etiology of elevated aminotransferase levels in the United States","volume":"98","author":"JM Clark","year":"2003","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2001-12926","article-title":"Clinical features and natural history of nonalcoholic steatosis syndromes","volume":"21","author":"Y Falck-Ytter","year":"2001","journal-title":"Semin Liver Dis"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"925","DOI":"10.7150\/ijms.8951","article-title":"Alanine Aminotransferase-Old Biomarker and New Concept: A Review","volume":"11","author":"Z Liu","year":"2014","journal-title":"Int. J. Med. Sci."},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00535-012-0651-7","article-title":"Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis","volume":"48","author":"Y Tamaki","year":"2013","journal-title":"J Gastroenterol"},{"issue":"13","key":"ref31","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1096\/fj.01-0125com","article-title":"HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia","volume":"15","author":"DM Stroka","year":"2001","journal-title":"FASEB J"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11325-014-1008-7","article-title":"Association between nocturnal hypoxia and liver injury in the setting of nonalcoholic fatty liver disease","volume":"19","author":"QC Lin","year":"2015","journal-title":"Sleep Breath"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/ijo.2012.8","article-title":"Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study","volume":"37","author":"J Zhao","year":"2013","journal-title":"Int J Obes (Lond)"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4161\/epi.27981","article-title":"Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemia","volume":"9","author":"SP Guay","year":"2014","journal-title":"Epigenetics"},{"issue":"13","key":"ref35","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1038\/emboj.2012.141","article-title":"DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns","volume":"31","author":"M Rigal","year":"2012","journal-title":"EMBO J"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1101\/gr.143503.112","article-title":"DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure","volume":"23","author":"S Gelfman","year":"2013","journal-title":"Genome Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0145944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:43:58Z","timestamp":1589013838000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0145944"}},"subtitle":[],"editor":[{"given":"Max","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0145944","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,30]]}}}