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Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1128\/IAI.70.9.4880-4891.2002","article-title":"The YadA protein of <italic>Yersinia pseudotuberculosis<\/italic> mediates high-efficiency uptake into human cells under environmental conditions in which invasin is repressed","volume":"70","author":"J Eitel","year":"2002","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1128\/IAI.56.5.1242-1248.1988","article-title":"Evidence for two genetic loci in <italic>Yersinia enterocolitica<\/italic> that can promote invasion of epithelial cells","volume":"56","author":"VL Miller","year":"1988","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0092-8674(90)90099-Z","article-title":"Multiple \u03b21 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells","volume":"60","author":"RR 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lines producing tumors in nude mice","volume":"59","author":"J Fogh","year":"1977","journal-title":"J Natl Cancer Inst"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2958.1994.tb00295.x","article-title":"Growth phase and low pH affect the thermal regulation of the <italic>Yersinia enterocolitica inv<\/italic> gene","volume":"11","author":"J Pepe","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002117","article-title":"Unique cell adhesion and invasion properties of yersinia enterocolitica O:3, the most frequent cause of human yersiniosis","volume":"7","author":"F Uliczka","year":"2011","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0005-2736(73)90434-3","article-title":"Purification of the human intestinal brush border membrane","volume":"323","author":"J Schmitz","year":"1973","journal-title":"Biochim Biophys Acta- Biomembranes"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"243252","DOI":"10.1016\/j.diff.2011.01.009","article-title":"The dual role of annexin II in targeting of brush border proteins and in intestinal cell polarity","volume":"81","author":"Z Hein","year":"2011","journal-title":"Differentiation"},{"key":"ref34","first-page":"323","article-title":"Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture","volume":"47","author":"M Pinto","year":"1983","journal-title":"Biol Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ijc.2910320403","article-title":"Sucrase\u2010isomaltase: A marker of foetal and malignant epithelial cells of the human colon","volume":"32","author":"A Zweibaum","year":"1983","journal-title":"Int J 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hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation","volume":"12","author":"GL Semenza","year":"1992","journal-title":"Mol Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-\u03b1 to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"P Jaakkola","year":"2001","journal-title":"Science"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1242\/jcs.102.3.427","article-title":"Differential expression of the VLA family of integrins along the crypt-villus axis in the human small intestine","volume":"102","author":"JF Beaulieu","year":"1992","journal-title":"J Cell Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1462-5822.2004.00391.x","article-title":"Expression and distribution of beta1 integrins in <italic>in vitro<\/italic>-induced M cells: implications for Yersinia adhesion to Peyer\u2019s patch epithelium","volume":"6","author":"N Hamzaoui","year":"2004","journal-title":"Cell Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","DOI":"10.1007\/BF00224348","article-title":"Interactions of <italic>Yersinia enterocolitica<\/italic> with polarized human intestinal Caco-2 cells","volume":"184","author":"J Curfs","year":"1995","journal-title":"Med Microbiol Immunol"},{"key":"ref47","first-page":"953","author":"JS Trier","year":"1988"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1128\/IAI.67.2.946-953.1999","article-title":"Human intestinal M cells display the sialyl Lewis A antigen","volume":"67","author":"PJ Giannasca","year":"1999","journal-title":"Infect Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/0300-9084(88)90271-4","article-title":"Comparison of the invasion strategies used by <italic>Salmonella cholerae-suis<\/italic>, <italic>Shigella flexneri<\/italic> and <italic>Yersinia enterocolitica<\/italic> to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication","volume":"70","author":"B Finlay","year":"1988","journal-title":"Biochimie"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1432-0436.1994.5810087.x","article-title":"How intestinal epithelial cell differentiation inhibits the cell-entry of <italic>Yersinia pseudotuberculosis<\/italic> in colon carcinoma Caco-2 cell line in culture","volume":"58","author":"MH Coconnier","year":"1994","journal-title":"Differentiation"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0016-5085(92)90829-N","article-title":"Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line","volume":"103","author":"PH Vachon","year":"1992","journal-title":"Gastroenterology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/(SICI)1097-4652(199601)166:1<198::AID-JCP21>3.0.CO;2-A","article-title":"Uncoordinated, transient mosaic patterns of intestinal hydrolase expression in differentiating human enterocytes","volume":"166","author":"P Vachon","year":"1996","journal-title":"J Cell Physiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1242\/jcs.115.3.543","article-title":"Integrin-mediated functional polarization of Caco-2 cells through E-cadherin-actin complexes","volume":"115","author":"C Schreider","year":"2002","journal-title":"J Cell Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1002\/eji.1830211018","article-title":"Expression, function and regulation of the intercellular adhesion molecule-1 (ICAM-1) on human intestinal epithelial cell lines","volume":"21","author":"D Kaiserlian","year":"1991","journal-title":"Eur J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/ar.1092350409","article-title":"Basement membrane formation and re-distribution of the beta 1 integrins in a human intestinal co-culture system","volume":"235","author":"PH Vachon","year":"1993","journal-title":"Anat Rec"},{"key":"ref56","article-title":"Effect of cell polarization and differentiation on entry of <italic>Listeria monocytogenes<\/italic> into the enterocyte-like Caco-2 cell line","author":"JL Gaillard","year":"1996","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/mpat.1997.0153","article-title":"<italic>Pseudomonas aeruginosa<\/italic> entry into Caco-2 cells is enhanced in repairing wounded monolayers","volume":"23","author":"SH Pereira","year":"1997","journal-title":"Microb Pathog"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1128\/jb.172.2.1062-1069.1990","article-title":"Nucleotide sequence of the <italic>Yersinia enterocolitica ail<\/italic> gene and characterization of the Ail protein product","volume":"172","author":"VL Miller","year":"1990","journal-title":"J Bacteriol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1128\/IAI.61.9.3914-3921.1993","article-title":"The <italic>Yersinia pseudotuberculosis<\/italic> adhesin YadA mediates intimate bacterial attachment to and entry into HEp-2 cells","volume":"61","author":"JB Bliska","year":"1993","journal-title":"Infect Immun"},{"key":"ref60","article-title":"Pathogenesis of defined invasion mutants of <italic>Yersinia enterocolitica<\/italic> in a BALB\/c mouse model of infection","author":"JC Pepe","year":"1995","journal-title":"Infect Immun"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1097\/MIB.0b013e31828dcaaf","article-title":"The inflammatory tissue microenvironment in IBD","volume":"19","author":"SP Colgan","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2362.2005.01567.x","article-title":"Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease","volume":"35","author":"OA Hatoum","year":"2005","journal-title":"Eur J Clin Invest"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.193.9.1027","article-title":"Hypoxia-inducible factor 1\u2013dependent induction of intestinal trefoil factor protects barrier function during hypoxia","volume":"193","author":"GT Furuta","year":"2001","journal-title":"J Exp Medic"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"GL Wang","year":"1995","journal-title":"PNAS"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.cellbio.15.1.551","article-title":"Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1","volume":"15","author":"GL Semenza","year":"1999","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1126\/science.1066373","article-title":"A Conserved family of prolyl-4-hydroxylases that modify HIF","volume":"294","author":"RK Bruick","year":"2001","journal-title":"Science"},{"key":"ref67","first-page":"112","article-title":"Hypoxia-inducible factor (HIF-1)\u03b1: its protein stability and biological functions","volume":"36","author":"J-W Lee","year":"2004","journal-title":"Exp Mol Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrd2761","article-title":"Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease","volume":"8","author":"P Fraisl","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"AC Epstein","year":"2001","journal-title":"Cell"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1073\/pnas.94.11.5667","article-title":"Activation of hypoxia-inducible factor 1\u03b1: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor","volume":"94","author":"P Kallio","year":"1997","journal-title":"PNAS"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors foroxygen-dependent proteolysis","volume":"399","author":"P Maxwell","year":"1999","journal-title":"Nature"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1073\/pnas.88.13.5680","article-title":"Hypoxia-inducible nuclear factors bind to an enhancer element located 3\u2019 to the human erythropoietin gene","volume":"88","author":"GL Semenza","year":"1991","journal-title":"PNAS"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0034-5687(95)00013-4","article-title":"Hypoxia-inducible gene expression","volume":"101","author":"J Fandrey","year":"1995","journal-title":"Respir Physiol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.90.9.4304","article-title":"General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia","volume":"90","author":"GL Wang","year":"1993","journal-title":"PNAS"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"GL Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1182\/blood.V92.7.2260","article-title":"Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1","volume":"92","author":"MS Wiesener","year":"1998","journal-title":"Blood"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1096\/fj.08-125344","article-title":"Selective induction of integrin \u03b21 by hypoxia-inducible factor: implications for wound healing","volume":"23","author":"S Keely","year":"2009","journal-title":"FASEB J"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1242\/jcs.155036","article-title":"Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation","volume":"128","author":"M Rana","year":"2015","journal-title":"J Cell Sci"},{"key":"ref79","first-page":"3126","article-title":"Hypoxia-induced changes to integrin \u03b1 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431. Mol Cell Proteomics","volume":"13","author":"Y Ren","year":"2014","journal-title":"MCP"},{"key":"ref80","first-page":"59","article-title":"Changes in beta(1) integrin in renal tubular epithelial cells after intrauterine asphyxia of rabbit pups","volume":"37","author":"B Yu","year":"2009","journal-title":"Journal of perinatal medicine"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1096\/fasebj.8.11.8070630","article-title":"Calpain: new perspectives in molecular diversity and physiological-pathological involvement","volume":"8","author":"TC Saido","year":"1994","journal-title":"FASEB J"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/0309-1651(91)90096-2","article-title":"Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases","volume":"15","author":"PD Wilson","year":"1991","journal-title":"Cell Biol Int Rep"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"C711","DOI":"10.1152\/ajpcell.1998.275.3.C711","article-title":"Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney","volume":"275","author":"A Zuk","year":"1998","journal-title":"Am J Physiol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1600-0897.2004.00236.x","article-title":"Cleavage of integrin by mu-calpain during hypoxia in human endometrial cells","volume":"52","author":"K Aoyama","year":"2004","journal-title":"Am J Rep Immunol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"17221","DOI":"10.1074\/jbc.R000005200","article-title":"Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts","volume":"275","author":"DA Brown","year":"2000","journal-title":"J Biol Chem"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.yexcr.2009.07.020","article-title":"Domains in biological membranes","volume":"315","author":"R Lindner","year":"2009","journal-title":"Exp Cell Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00424-005-1413-7","article-title":"Hypoxia-responsive transcription factors. Pfl\u00fcgers Archiv","volume":"450","author":"EP Cummins","year":"2005","journal-title":"Eur J Physiol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1749-6632.2009.05030.x","article-title":"Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis","volume":"1177","author":"VH Haase","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1111\/febs.13270","article-title":"The impact of hypoxia on bacterial infection","volume":"282","author":"K Schaffer","year":"2015","journal-title":"FEBS J"},{"key":"ref90","doi-asserted-by":"crossref","DOI":"10.1590\/S0036-46652013000500008","article-title":"Hypoxic stress, hepatocytes and Caco-2 viability and susceptibility to <italic>Shigella flexneri<\/italic> invasion","volume":"55","author":"C Lima","year":"2013","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"e56491","DOI":"10.1371\/journal.pone.0056491","article-title":"Hypoxia modulates infection of epithelial cells by <italic>Pseudomonas aeruginosa<\/italic>","volume":"8","author":"B Schaible","year":"2013","journal-title":"PLoS ONE"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00109-012-0882-3","article-title":"A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection","volume":"90","author":"CY Okumura","year":"2012","journal-title":"J Mol Med"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/mi.2013.29","article-title":"Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis","volume":"7","author":"S Keely","year":"2014","journal-title":"Mucosal Immunol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1086\/524843","article-title":"Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes","volume":"197","author":"A Zinkernagel","year":"2008","journal-title":"J Infect Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0146103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T23:11:40Z","timestamp":1654038700000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0146103"}},"subtitle":[],"editor":[{"given":"J\u00f6rn","family":"Karhausen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,5]]},"references-count":94,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0146103","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,5]]}}}