{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:26Z","timestamp":1792098386315,"version":"4.4.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0146276","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T18:35:33Z","timestamp":1455042933000},"page":"e0146276","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Different Gene Expression Signatures in Children and Adults with Celiac Disease"],"prefix":"10.1371","volume":"11","author":[{"given":"V.","family":"Pascual","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"L\u00f3pez-Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bodas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fern\u00e1ndez-Arquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gonz\u00e1lez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1053\/j.gastro.2005.02.014","article-title":"The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review","volume":"128","author":"C Dube","year":"2005","journal-title":"Gastroenterology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1053\/j.gastro.2015.01.044","article-title":"Advances in diagnosis and management of celiac disease","volume":"148","author":"CP Kelly","year":"2015","journal-title":"Gastroenterology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12664-013-0339-9","article-title":"Pediatric and adult celiac disease: similarities and differences","volume":"32","author":"U Poddar","year":"2013","journal-title":"Indian J Gastroenterol"},{"issue":"5","key":"ref4","first-page":"238","article-title":"Differences between pediatric and adult celiac disease","volume":"103","author":"L Rodrigo-Saez","year":"2011","journal-title":"Rev Esp Enferm Dig"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.3390\/nu7105426","article-title":"The Spectrum of Differences between Childhood and Adulthood Celiac Disease","volume":"7","author":"R Ciccocioppo","year":"2015","journal-title":"Nutrients"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4292\/wjgpt.v6.i4.207","article-title":"Age-related differences in celiac disease: Specific characteristics of adult presentation","volume":"6","author":"S Vivas","year":"2015","journal-title":"World J Gastrointest Pharmacol Ther"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"G Trynka","year":"2011","journal-title":"Nat Genet"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ng.543","article-title":"Multiple common variants for celiac disease influencing immune gene expression","volume":"42","author":"PC Dubois","year":"2010","journal-title":"Nat Genet"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/ddu453","article-title":"Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels","volume":"24","author":"V Kumar","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/ng.3268","article-title":"Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease","volume":"47","author":"J Gutierrez-Achury","year":"2015","journal-title":"Nat Genet"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/hmg\/ddt520","article-title":"Coregulation and modulation of NFkappaB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation","volume":"23","author":"N Fernandez-Jimenez","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MPG.0000000000000338","article-title":"Alteration of tight junction gene expression in celiac disease","volume":"58","author":"A Jauregi-Miguel","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/00365521.2013.863966","article-title":"Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease","volume":"49","author":"AI Lahdenpera","year":"2014","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1172\/JCI78085","article-title":"Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity","volume":"125","author":"PR Burkett","year":"2015","journal-title":"J Clin Invest"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.autrev.2014.08.019","article-title":"Th17 cells in inflammation and autoimmunity","volume":"13","author":"RP Singh","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/08916930802350789","article-title":"TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin","volume":"42","author":"A Castellanos-Rubio","year":"2009","journal-title":"Autoimmunity"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/ajg.2010.465","article-title":"Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patients","volume":"106","author":"S Fernandez","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.4049\/jimmunol.0901919","article-title":"Characterization of IL-17A-producing cells in celiac disease mucosa","volume":"184","author":"I Monteleone","year":"2010","journal-title":"J Immunol"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition","volume":"65","year":"1990","journal-title":"Arch Dis Child"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1053\/j.gastro.2006.10.003","article-title":"AGA Institute Medical Position Statement on the Diagnosis and Management of Celiac Disease","volume":"131","year":"2006","journal-title":"Gastroenterology"},{"key":"ref21","unstructured":"geNorm, version3.5. Center for Medical Genetics. Ghent University; Ghent, Belgium. 2007."},{"key":"ref22","unstructured":"NormFinder, version0.953. Aarhus University Hospital; Aarhus, Denmark. 2005."},{"issue":"13","key":"ref23","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1080\/03610921003778183","article-title":"Bayesian analysis of multiple hypothesis testing with applications to microarray experiments","volume":"40","author":"MC Aus\u00edn","year":"2011","journal-title":"Communications in Statistics\u2014Theory and Methods"},{"issue":"1","key":"ref24","first-page":"49","article-title":"A Bayesian decision procedure for testing multiple hypotheses in DNA microarray experiments","volume":"13","author":"MA Gomez-Villegas","year":"2014","journal-title":"Stat Appl Genet Mol Biol"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/jmg.2011.089714","article-title":"Revisiting genome wide association studies (GWAS) in coeliac disease: replication study in Spanish population and expression analysis of candidate genes","volume":"48","author":"L Plaza-Izurieta","year":"2011","journal-title":"J Med Genet"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"e74747","DOI":"10.1371\/journal.pone.0074747","article-title":"Gene expression profile of peripheral blood monocytes: a step towards the molecular diagnosis of celiac disease?","volume":"8","author":"M Galatola","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ejhg.2014.244","article-title":"Expression analysis in intestinal mucosa reveals complex relations among genes under the association peaks in celiac disease","volume":"23","author":"L Plaza-Izurieta","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/gut.2008.169052","article-title":"Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling","volume":"58","author":"G Trynka","year":"2009","journal-title":"Gut"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ng.102","article-title":"Newly identified genetic risk variants for celiac disease related to the immune response","volume":"40","author":"KA Hunt","year":"2008","journal-title":"Nat Genet"},{"issue":"5","key":"ref30","first-page":"482","article-title":"miRNA-regulated gene expression differs in celiac disease patients according to the age of presentation","volume":"10","author":"Comani G Buoli","year":"2015","journal-title":"Genes Nutr"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/mi.2013.19","article-title":"Increased production of interleukin-21, but not interleukin-17A, in the small intestine characterizes pediatric celiac disease","volume":"6","author":"MA van Leeuwen","year":"2013","journal-title":"Mucosal Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"D Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0146276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T20:07:24Z","timestamp":1654286844000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0146276"}},"subtitle":[],"editor":[{"given":"Massimo","family":"Pietropaolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0146276","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}