{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:27:31Z","timestamp":1782552451510,"version":"3.54.5"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0146711","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T19:16:29Z","timestamp":1452539789000},"page":"e0146711","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands"],"prefix":"10.1371","volume":"11","author":[{"given":"Eri O.","family":"Maruyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit H.","family":"Aure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Myal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Ovitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"ref1","author":"C Pinkstaff","year":"1993"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1749-6632.1998.tb09641.x","article-title":"Acquired salivary dysfunction. Drugs and radiation","volume":"842","author":"PC Fox","year":"1998","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"e2063","DOI":"10.1371\/journal.pone.0002063","article-title":"Rescue of salivary gland function after stem cell transplantation in irradiated glands","volume":"3","author":"IM Lombaert","year":"2008","journal-title":"PLoS One"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.radonc.2013.05.020","article-title":"Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland","volume":"108","author":"LS Nanduri","year":"2013","journal-title":"Radiother Oncol"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1172\/JCI74096","article-title":"Neurotrophic factor GDNF promotes survival of salivary stem cells","volume":"124","author":"N Xiao","year":"2014","journal-title":"J Clin Invest"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/stem.1327","article-title":"Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia","volume":"31","author":"S Pringle","year":"2013","journal-title":"Stem Cells"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.devcel.2015.02.013","article-title":"Salivary gland homeostasis is maintained through acinar cell self-duplication","volume":"33","author":"MH Aure","year":"2015","journal-title":"Dev Cell"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1139\/Y09-077","article-title":"Generation and initial characterization of the prolactin-inducible protein (PIP) null mouse: accompanying global changes in gene expression in the submandibular gland","volume":"87","author":"A Blanchard","year":"2009","journal-title":"Can J Physiol Pharmacol"},{"issue":"31","key":"ref9","doi-asserted-by":"crossref","first-page":"15236","DOI":"10.1016\/S0021-9258(18)48164-1","article-title":"Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D","volume":"262","author":"LC Murphy","year":"1987","journal-title":"J Biol Chem"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1210\/endo.135.4.7925123","article-title":"Tissue-specific androgen-inhibited gene expression of a submaxillary gland protein, a rodent homolog of the human prolactin-inducible protein\/GCDFP-15 gene","volume":"135","author":"Y Myal","year":"1994","journal-title":"Endocrinology"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/0003-9969(94)90052-3","article-title":"cDNA cloning, sequencing and in situ localization of a transcript specific to both sublingual demilune cells and parotid intercalated duct cells in mouse salivary glands","volume":"39","author":"I Bekhor","year":"1994","journal-title":"Arch Oral Biol"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/physiolgenomics.00153.2006","article-title":"Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1\/Dcpp salivary protein family","volume":"28","author":"JJ Mullins","year":"2006","journal-title":"Physiol Genomics"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/aja.1001530304","article-title":"Cytodifferentiation of secretory cells in the sublingual gland of the prenatal rat: a histological, histochemical and ultrastructural study","volume":"153","author":"RS Redman","year":"1978","journal-title":"Am J Anat"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0012-1606(88)90210-2","article-title":"Secretory proteins as markers for cellular phenotypes in rat salivary glands","volume":"125","author":"WD Ball","year":"1988","journal-title":"Dev Biol"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0012-1606(88)90393-4","article-title":"A secretory protein restricted to type I cells in neonatal rat submandibular glands","volume":"129","author":"WD Ball","year":"1988","journal-title":"Dev Biol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","article-title":"Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice","volume":"9","author":"K Arnold","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1074\/jbc.M008167200","article-title":"CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors","volume":"276","author":"S Rodda","year":"2001","journal-title":"J Biol Chem"},{"issue":"23","key":"ref18","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1242\/dev.02658","article-title":"Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse","volume":"133","author":"Y Yamaguchi","year":"2006","journal-title":"Development"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2008.03.044","article-title":"Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo","volume":"319","author":"JW Mugford","year":"2008","journal-title":"Dev Biol"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1177\/002215549804600910","article-title":"Expression of gross cystic disease fluid protein-15\/Prolactin-inducible protein in rat salivary glands","volume":"46","author":"L Mirels","year":"1998","journal-title":"J Histochem Cytochem"},{"issue":"1\u20132","key":"ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0303-7207(03)00210-7","article-title":"Expression of the mouse homologue for the human GCDFP-15\/PIP gene during pre- and early post-natal development","volume":"205","author":"B Lee","year":"2003","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"ref22","first-page":"105","article-title":"Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features","volume":"110","author":"G Mazoujian","year":"1983","journal-title":"Am J Pathol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/(SICI)1097-0185(19990301)254:3<408::AID-AR12>3.0.CO;2-G","article-title":"Dynamics of parenchymal cell division, differentiation, and apoptosis in the young adult female mouse submandibular gland","volume":"254","author":"PC Denny","year":"1999","journal-title":"Anat Rec"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ar.1098","article-title":"Contributions of intercalated duct cells to the normal parenchyma of submandibular glands of adult rats","volume":"263","author":"YG Man","year":"2001","journal-title":"Anat Rec"},{"key":"ref25","first-page":"143","article-title":"The rat parotid gland\u2014a renewing cell population","volume":"161","author":"D Schwartz-Arad","year":"1988","journal-title":"J Anat"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/ar.1092130206","article-title":"The streaming submandibular gland","volume":"213","author":"G Zajicek","year":"1985","journal-title":"Anat Rec"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/scd.2014.0355","article-title":"Analysis of histone H2BGFP retention in mouse submandibular gland reveals actively dividing stem cell populations","volume":"24","author":"M Kwak","year":"2015","journal-title":"Stem Cells Dev"},{"key":"ref28","article-title":"Salivary Glands: Stem Cells, Self-duplication, or Both?","author":"MH Aure","year":"2015","journal-title":"J Dent Res"},{"issue":"19","key":"ref29","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1038\/emboj.2013.177","article-title":"Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor","volume":"32","author":"G Martello","year":"2013","journal-title":"EMBO J"},{"issue":"19","key":"ref30","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1038\/emboj.2013.175","article-title":"Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1","volume":"32","author":"S Ye","year":"2013","journal-title":"EMBO J"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/1097-0142(19890601)63:11<2156::AID-CNCR2820631115>3.0.CO;2-B","article-title":", Haagensen CD. Expression of GCDFP-15 in breast carcinomas. Relationship to pathologic and clinical factors","volume":"63","author":"G Mazoujian","year":"1989","journal-title":"Cancer"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/75973","article-title":"High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP","volume":"25","author":"CI Rodriguez","year":"2000","journal-title":"Nat Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0146711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T10:35:14Z","timestamp":1654079714000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0146711"}},"subtitle":[],"editor":[{"given":"John A","family":"Chiorini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0146711","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,11]]}}}